XAF1 as a modifier of p53 function and cancer susceptibility

Autor: Patricia Ashton-Prolla, Tatiana Ei-Jaick B Costa, Madson Q. Almeida, Maria Nirvana Formiga, Berenice B. Mendonca, Kara N. Maxwell, Geoffrey Neale, Mariana M Paraizo, Andrew J. Murphy, Enzo Lalli, Meredith Yeager, Jinghui Zhang, Laurence Brugières, Ana Claudia Latronico, Jinling Wang, Wenan Chen, Carolina Mathias, Evadnie Rampersaud, Gang Wu, Dominique Vaur, Sharon A. Savage, Sahlua Volc, Vania Balderrama Brondani, Gabriela E. S. Felix, Camila Matzenbacher Bittar, Elena M. Stoffel, Enilze Maria de Souza Fonseca Ribeiro, Hector Salvador, Vicente Odone-Filho, Kristine Jones, Tobias Else, Kayla V. Hamilton, Alberto S. Pappo, Edenir Inêz Palmero, Guillermo L. Chantada, Karina Miranda Santiago, Emerson Wander Silva Soares, Moara Machado, Kim E. Nichols, Maria Isabel Achatz, Payal P. Klincha, Cintia Regina Niederauer Ramos, Kelvin C. de Andrade, Luis Kowalski, Raul C. Ribeiro, Heloisa Komechen, Aurelie Vogt, Jon P. Connelly, Yoan Diekmann, Márta Korbonits, Eric Letouzé, Maria Candida Barisson Villares Fragoso, Bonald C. Figueiredo, Carlos Rodriguez-Galindo, Ivy Zortéa S Parise, Cinzia Lavarino, Gerard P. Zambetti, Henrique de Campos Reis Galvão, Weiyin Zhou, Shondra M. Pruett-Miller, Michael R. Clay, Emilia M. Pinto, Mark G. Thomas, Jose Luis Fuster-Soler

Publikováno v: Science Advances
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu

The XAF1-E134* variant increases the cancer risk for carriers of the TP53-R337H allele.
Cancer risk is highly variable in carriers of the common TP53-R337H founder allele, possibly due to the influence of modifier genes. Whole-genome sequencing

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http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17947