Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Payal P, Pratap"'
Autor:
Christopher A. Cottrell, Payal P. Pratap, Kimberly M. Cirelli, Diane G. Carnathan, Chiamaka A. Enemuo, Aleksandar Antanasijevic, Gabriel Ozorowski, Leigh M. Sewall, Hongmei Gao, Joel D. Allen, Bartek Nogal, Murillo Silva, Jinal Bhiman, Matthias Pauthner, Darrell J. Irvine, David Montefiori, Max Crispin, Dennis R. Burton, Guido Silvestri, Shane Crotty, Andrew B. Ward
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract Immunodominance of antibodies targeting non-neutralizing epitopes and the high level of somatic hypermutation within germinal centers (GCs) required for most HIV broadly neutralizing antibodies (bnAbs) are major impediments to the developmen
Externí odkaz:
https://doaj.org/article/bdb802dbabe14d2b9e05554af9fa7556
Autor:
Starlynn C. Clarke, Biao Ma, Nathan D. Trinklein, Ute Schellenberger, Michael J. Osborn, Laure-Hélène Ouisse, Andrew Boudreau, Laura M. Davison, Katherine E. Harris, Harshad S. Ugamraj, Aarti Balasubramani, Kevin H. Dang, Brett Jorgensen, Heather Anne N. Ogana, Duy T. Pham, Payal P. Pratap, Preethi Sankaran, Ignacio Anegon, Wim C. van Schooten, Marianne Brüggemann, Roland Buelow, Shelley Force Aldred
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Heavy chain-only antibodies (HCAbs) do not associate with light chains and their VH regions are functional as single domains, forming the smallest active antibody fragment. These VH regions are ideal building blocks for a variety of antibody-based bi
Externí odkaz:
https://doaj.org/article/6a706cdfcb4649ab82279f4b31c5c13b
Autor:
Katherine E. Harris, Shelley Force Aldred, Laura M. Davison, Heather Anne N. Ogana, Andrew Boudreau, Marianne Brüggemann, Michael Osborn, Biao Ma, Benjamin Buelow, Starlynn C. Clarke, Kevin H. Dang, Suhasini Iyer, Brett Jorgensen, Duy T. Pham, Payal P. Pratap, Udaya S. Rangaswamy, Ute Schellenberger, Wim C. van Schooten, Harshad S. Ugamraj, Omid Vafa, Roland Buelow, Nathan D. Trinklein
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
We created a novel transgenic rat that expresses human antibodies comprising a diverse repertoire of heavy chains with a single common rearranged kappa light chain (IgKV3-15-JK1). This fixed light chain animal, called OmniFlic, presents a unique syst
Externí odkaz:
https://doaj.org/article/0e55864017b746d182977ff0f5e8bf28
Autor:
Dingens AS; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, United States., Pratap P; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States., Malone K; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, United States., Hilton SK; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, United States., Ketas T; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, United States., Cottrell CA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States., Overbaugh J; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, United States., Moore JP; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, United States., Klasse PJ; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, United States., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States., Bloom JD; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, United States.; Howard Hughes Medical Institute, Seattle, United States.
Publikováno v:
ELife [Elife] 2021 Jan 13; Vol. 10. Date of Electronic Publication: 2021 Jan 13.