Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Paxtyn M. Fisher"'
Autor:
Wenxu Zhou, Paxtyn M. Fisher, Boden H. Vanderloop, Yun Shen, Huazhong Shi, Adrian J. Maldonado, David J. Leaver, W. David Nes
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 2, Pp 192-204 (2020)
Primitive sterol evolution plays an important role in fossil record interpretation and offers potential therapeutic avenues for human disease resulting from nematode infections. Recognizing that C4-methyl stenol products [8(14)-lophenol] can be synth
Externí odkaz:
https://doaj.org/article/02378f2c8d70426382e780781511bfb5
Autor:
Wenxu Zhou, Emilio Ramos, Xunlu Zhu, Paxtyn M. Fisher, Medhanie E. Kidane, Boden H. Vanderloop, Crista D. Thomas, Juqiang Yan, Ujjal Singha, Minu Chaudhuri, Michael T. Nagel, W.David Nes
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 5, Pp 981-994 (2019)
Pathogenic organisms may be sensitive to inhibitors of sterol biosynthesis, which carry antimetabolite properties, through manipulation of the key enzyme, sterol methyltransferase (SMT). Here, we isolated natural suicide substrates of the ergosterol
Externí odkaz:
https://doaj.org/article/09be2b3fa76c4660b95ac736ad3c5f60
Autor:
Emilio Ramos, Juqiang Yan, Minu Chaudhuri, Paxtyn M. Fisher, W. David Nes, Ujjal K. Singha, Medhanie E. Kidane, Crista D. Thomas, Michael T. Nagel, Xunlu Zhu, Wenxu Zhou, Boden H. Vanderloop
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 5, Pp 981-994 (2019)
Pathogenic organisms may be sensitive to inhibitors of sterol biosynthesis, which carry antimetabolite properties, through manipulation of the key enzyme, sterol methyltransferase (SMT). Here, we isolated natural suicide substrates of the ergosterol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a972613f0c255aa6aa0b0cfd9238363
https://doi.org/10.1194/jlr.m091587
https://doi.org/10.1194/jlr.m091587
Autor:
Stella A. Child, Zdzislaw Wawrzak, Paxtyn M. Fisher, Galina I. Lepesheva, Tatiana Y. Hargrove, Michael R. Waterman, W. David Nes, F. Peter Guengerich
Publikováno v:
Journal of Biological Chemistry. 293:19344-19353
Sterol 14α-demethylases (CYP51s) are phylogenetically the most conserved cytochromes P450, and their three-step reaction is crucial for biosynthesis of sterols and serves as a leading target for clinical and agricultural antifungal agents. The struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bd78ee619055bd9ef40cd55b0e57d3
https://doi.org/10.1074/jbc.ra118.005850
https://doi.org/10.1074/jbc.ra118.005850
Autor:
Paxtyn M. Fisher, W. David Nes, Tatiana Y. Hargrove, Girish Rachakonda, Anna L. Blobaum, Craig W. Lindsley, Galina I. Lepesheva, Cristiane França da Silva, Fernando Villalta, F. Peter Guengerich, Gabriel Melo de Oliveira, Laura Friggeri, Maria de Nazaré Correia Soeiro
Publikováno v:
Journal of Medicinal Chemistry. 61:10910-10921
Sterol 14α-demethylases (CYP51) are cytochrome P450 enzymes essential for sterol biosynthesis in eukaryotes and therapeutic targets for antifungal azoles. Multiple attempts to repurpose antifungals for treatment of human infections with protozoa (Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5b1cb0c4c1a247385e95bdbfc02850
https://doi.org/10.1021/acs.jmedchem.8b01671
https://doi.org/10.1021/acs.jmedchem.8b01671
Autor:
W. David Nes, Andrew G. S. Warrilow, Boden H. Vanderloop, Steven L. Kelly, Crista D. Thomas, Wenxu Zhou, Emilio Ramos, Paxtyn M. Fisher, Claire L. Price, Diane E. Kelly, Josie E. Parker, Michael D. Loftis
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1863:1164-1178
The sterol metabolome of Acanthamoeba castellanii (Ac) yielded 25 sterols. Substrate screening of cloned AcCYP51 revealed obtusifoliol as the natural substrate which converts to Δ(8,14)-sterol (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a01aeb7b2cfd1d5d9540c0a88dfe952
https://doi.org/10.1016/j.bbalip.2018.07.004
https://doi.org/10.1016/j.bbalip.2018.07.004