Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Pawel Stocki"'
Autor:
Pawel Stocki, Jaroslaw Szary, Mykhaylo Demydchuk, Leandra Northall, Charlotte L. M. Rasmussen, Diana Bahu Logan, Aziz Gauhar, Laura Thei, Shu-Fen Coker, Torben Moos, Frank S. Walsh, J. Lynn Rutkowski
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 739 (2023)
Since the delivery of biologic drugs to the brain is greatly hampered by the existence of the blood–brain barrier (BBB), brain shuttles are being developed to enhance therapeutic efficacy. As we have previously shown, efficient and selective brain
Externí odkaz:
https://doaj.org/article/82000d2623a94836867f72035c2923dd
Autor:
Emily Clarke, Pawel Stocki, Elizabeth H. Sinclair, Aziz Gauhar, Edward J. R. Fletcher, Alicja Krawczun-Rygmaczewska, Susan Duty, Frank S. Walsh, Patrick Doherty, Julia Lynn Rutkowski
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1335 (2022)
Single domain shark antibodies that bind to the transferrin receptor 1 (TfR1) on brain endothelial cells have been used to shuttle antibodies and other cargos across the blood brain barrier (BBB) to the brain. For these studies the TXB4 brain shuttle
Externí odkaz:
https://doaj.org/article/7e8201a7d0904e04a5f05e9349a1bc37
Autor:
Sandrine Guillard, Paulina Kolasinska-Zwierz, Judit Debreczeni, Jason Breed, Jing Zhang, Nicolas Bery, Rose Marwood, Jon Tart, Ross Overman, Pawel Stocki, Bina Mistry, Christopher Phillips, Terence Rabbitts, Ronald Jackson, Ralph Minter
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Ras is mutated in many cancers, but so far no drug targeting Ras is in clinical use despite great efforts. Here the authors structurally and functionally characterize a DARPin that potently inhibits the nucleotide exchange of Ras, which might facilit
Externí odkaz:
https://doaj.org/article/511b9c0f118d47a5b8dc1ab52f044f6e
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145458 (2015)
Human cytomegalovirus uses a variety of mechanisms to evade immune recognition through major histocompatibility complex class I molecules. One mechanism mediated by the immunoevasin protein US2 causes rapid disposal of newly synthesized class I molec
Externí odkaz:
https://doaj.org/article/c9019b9f06004f24a486fd78f3598ec1
Autor:
Pawel Stocki, Anne M. Dickinson
Publikováno v:
Autoimmune Diseases, Vol 2012 (2012)
Heat shock protein 70 (HSP70) has previously been described as a potent antitumour vaccine. The mechanism relied on the ability of tumour derived HSP70 to associate with antigenic peptides, which, when cross presented, elicited a T cell mediated anti
Externí odkaz:
https://doaj.org/article/3628091179ce4b9fb6c2af270050a947
Autor:
Stina Syvänen, Greta Hultqvist, Frank S. Walsh, Tobias Gustavsson, J Lynn Rutkowski, Dag Sehlin, Pawel Stocki
Publikováno v:
The FASEB Journal. 34:13272-13283
Transferrin receptor 1 (TfR1) mediated transcytosis is an attractive strategy to enhance brain uptake of protein drugs, but translation remains a challenge. Here, a single domain shark antibody VNAR fragment (TXB2) with similar affinity to murine and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096b68c6da4c11e14820fc68570f777a
https://doi.org/10.1096/fj.202000610rr
https://doi.org/10.1096/fj.202000610rr
Autor:
Frank S. Walsh, Aziz Gauhar, Mykhaylo Demydchuk, Tanja Gerlza, Julia Rieger, J Lynn Rutkowski, Andreas J. Kungl, Pawel Stocki, Cyril V Privezentzev
Single domain shark VNAR antibodies can offer a viable alternative to conventional Ig-based monoclonal antibodies in treating COVID-19 disease during the current pandemic. Here we report the identification of neutralizing single domain VNAR antibodie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89bf29fccacfd0f1c5a543faa5b5aeb9
https://doi.org/10.1101/2021.06.08.447530
https://doi.org/10.1101/2021.06.08.447530
Autor:
Leandra Northall, Charlotte L M Rasmussen, Laura Thei, Mykhaylo Demydchuk, Aziz Gauhar, Diana Bahu Logan, Frank S. Walsh, Torben Moos, J Lynn Rutkowski, Pawel Stocki, Jaroslaw Szary
Publikováno v:
Stocki, P, Szary, J, Rasmussen, C L M, Demydchuk, M, Northall, L, Logan, D B, Gauhar, A, Thei, L, Moos, T, Walsh, F S & Rutkowski, J L 2021, ' Blood-brain barrier transport using a high affinity, brain-selective VNAR antibody targeting transferrin receptor 1 ', F A S E B Journal, vol. 35, no. 2, e21172 . https://doi.org/10.1096/fj.202001787R
Transfer across the blood-brain barrier (BBB) remains a significant hurdle for the development of biopharmaceuticals with therapeutic effects within the central nervous system. We established a functional selection method to identify high affinity si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abcb8c69b6a774da4636b59659b1a3a
https://doi.org/10.1096/fj.202001787r
https://doi.org/10.1096/fj.202001787r
Autor:
Alicja Krawczun-Rygmaczewska, Pawel Stocki, Frank S. Walsh, Sinclair L, Rutowski Jl, Fletcher Ejr, Susan Duty, Patrick Doherty, Clarke E
Single domain shark antibodies that bind to the transferrin receptor 1 (TfR1) on brain endothelial cells can be used to shuttle antibodies and other cargos across the blood brain barrier (BBB). We have fused one of these (TXB4) to differing regions o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::944224b3e7af16a5077c2c7ccf57fd68
https://doi.org/10.1101/2020.03.12.987313
https://doi.org/10.1101/2020.03.12.987313
Autor:
Mykhaylo Demydchuk, Pawel Stocki, Frank S. Walsh, Logan Db, Thei L, Torben Moos, Jaroslaw Szary, Leandra Northall, Rutkowski Jl, Aziz Gauhar, Rasmussen Cl
Transfer across the blood-brain barrier (BBB) remains a significant hurdle for the development of biopharmaceuticals with therapeutic effects within the central nervous system. We established a functional selection method to identify high-affinity si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f145e286ce1af9671f6fbaa17f13560
https://doi.org/10.1101/816900
https://doi.org/10.1101/816900