Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Pawel Pasznik"'
Autor:
Pawel Pasznik, Ewelina Rutkowska, Szymon Niewieczerzal, Judyta Cielecka-Piontek, Dorota Latek
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210705 (2019)
The prolonged use of many currently available drugs results in the severe side effect of the disruption of glucose metabolism leading to type 2 diabetes mellitus (T2DM. Gut hormone receptors including glucagon receptor (GCGR) and the incretin hormone
Externí odkaz:
https://doaj.org/article/9f66b019196849ba9fee258569c7ae1a
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56742 (2013)
G-protein coupled receptors (GPCRs) are targets of nearly one third of the drugs at the current pharmaceutical market. Despite their importance in many cellular processes the crystal structures are available for less than 20 unique GPCRs of the Rhodo
Externí odkaz:
https://doaj.org/article/5217492362394d63883968ab75f7a81b
Autor:
Robert Preissner, Slawomir Filipek, Jakub Jakowiecki, Urszula Orzeł, Pawel Pasznik, Renata Abel
Publikováno v:
Molecules, Vol 26, Iss 2456, p 2456 (2021)
Molecules
Volume 26
Issue 9
Molecules
Volume 26
Issue 9
The CB1 cannabinoid receptor (CB1R) contains one of the longest N termini among class A G protein-coupled receptors. Mutagenesis studies suggest that the allosteric binding site of cannabidiol (CBD) involves residues from the N terminal domain. In or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb09c905a0214e3a49ef4d73eed03e3b
https://www.mdpi.com/1420-3049/26/9/2456
https://www.mdpi.com/1420-3049/26/9/2456
Publikováno v:
Methods in Molecular Biology ISBN: 9781071612200
Homology modeling methods are commonly used for quick and precise construction of a desired protein or its mutant using protein templates, which were determined by crystallography, cryo-EM, or NMR. Due to the increasing number of such structures, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be38897d56fd3553a05b32c5dc11caf9
https://doi.org/10.1007/978-1-0716-1221-7_20
https://doi.org/10.1007/978-1-0716-1221-7_20
GPCRM: a homology modeling web service with triple membrane-fitted quality assessment of GPCR models
Autor:
Agnieszka Sztyler, Slawomir Filipek, Przemyslaw Miszta, Jakub Jakowiecki, Dorota Latek, Pawel Pasznik
Publikováno v:
Nucleic Acids Research
Due to the involvement of G protein-coupled receptors (GPCRs) in most of the physiological and pathological processes in humans they have been attracting a lot of attention from pharmaceutical industry as well as from scientific community. Therefore,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ec165559c627a8f83c31dc98470387
https://doi.org/10.1093/nar/gky429
https://doi.org/10.1093/nar/gky429
Autor:
Dorota Latek, Pawel Pasznik, Krzysztof Mlynarczyk, Przemyslaw Miszta, Slawomir Filipek, Jakub Jakowiecki, Ewelina Rutkowska
Publikováno v:
Bioinformatics and Biomedical Engineering ISBN: 9783319561530
IWBBIO (2)
CIÊNCIAVITAE
National Information Processing Institute
IWBBIO (2)
CIÊNCIAVITAE
National Information Processing Institute
A novel versatile tool named GPCRM has been developed. It targets structure prediction of a distinct protein family of G protein-coupled receptors (GPCRs). In principle, GPCRM builds a GPCR model using a MODELLER-based homology modeling procedure. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04cf034248b5c2a1527ac5b8b7bbc682
https://doi.org/10.1007/978-3-319-56154-7_15
https://doi.org/10.1007/978-3-319-56154-7_15
Publikováno v:
Nucleic Acids Research
The LassoProt server, http://lassoprot.cent.uw.edu.pl/, enables analysis of biopolymers with entangled configurations called lassos. The server offers various ways of visualizing lasso configurations, as well as their time trajectories, with all the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa288f3eb2ec4a3ab83ec34f159ee113
https://pubmed.ncbi.nlm.nih.gov/27131383
https://pubmed.ncbi.nlm.nih.gov/27131383
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56742 (2013)
PLoS ONE
PLoS ONE
G-protein coupled receptors (GPCRs) are targets of nearly one third of the drugs at the current pharmaceutical market. Despite their importance in many cellular processes the crystal structures are available for less than 20 unique GPCRs of the Rhodo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7842d9d439098daf5d8cfa9772ea619
http://europepmc.org/articles/PMC3585245?pdf=render
http://europepmc.org/articles/PMC3585245?pdf=render
Autor:
Jakub Jakowiecki, Renata Abel, Urszula Orzeł, Paweł Pasznik, Robert Preissner, Sławomir Filipek
Publikováno v:
Molecules, Vol 26, Iss 9, p 2456 (2021)
The CB1 cannabinoid receptor (CB1R) contains one of the longest N termini among class A G protein-coupled receptors. Mutagenesis studies suggest that the allosteric binding site of cannabidiol (CBD) involves residues from the N terminal domain. In or
Externí odkaz:
https://doaj.org/article/007d1f4d20d541678928de7c3bdebe39