Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Pawel Paszek"'
Autor:
Liam Feltham, Josephine Moran, Marie Goldrick, Elizabeth Lord, David G. Spiller, Jennifer S. Cavet, Mark Muldoon, Ian. S. Roberts, Pawel Paszek
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Dissemination of food-borne L. monocytogenes in the host relies on internalin-mediated invasion, but the underlying invasion strategies remain elusive. Here we use live-cell microscopy to follow single cell interactions between individual human cells
Externí odkaz:
https://doaj.org/article/6f37f87fb20348498905d94b4d73c328
Autor:
Josephine Moran, Liam Feltham, James Bagnall, Marie Goldrick, Elizabeth Lord, Catherine Nettleton, David G. Spiller, Ian Roberts, Pawel Paszek
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Pathogens have developed intricate strategies to overcome the host’s innate immune responses. In this paper we use live-cell microscopy with a single bacterium resolution to follow in real time interactions between the food-borne pathogen L. monocy
Externí odkaz:
https://doaj.org/article/69fdee6a62aa4abfa1029b6156b2163f
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Transcription of almost all mammalian genes occurs in stochastic bursts, however the fundamental control mechanisms that allow appropriate single-cell responses remain unresolved. Here we utilise single cell genomics data and stochastic models of tra
Externí odkaz:
https://doaj.org/article/90149c8ef4ff43b2bbeac6a4051f5242
Autor:
Polly Downton, James S. Bagnall, Hazel England, David G. Spiller, Neil E. Humphreys, Dean A. Jackson, Pawel Paszek, Michael R. H. White, Antony D. Adamson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Cells respond to inflammatory stimuli such as cytokines by activation of the nuclear factor-κB (NF-κB) signalling pathway, resulting in oscillatory translocation of the transcription factor p65 between nucleus and cytoplasm in some cell types. We i
Externí odkaz:
https://doaj.org/article/0ae9f541650a4de1829a089cf962e69c
Autor:
Eirini Kalliara, Malgorzata Kardynska, James Bagnall, David G. Spiller, Werner Müller, Dominik Ruckerl, Jarosław Śmieja, Subhra K. Biswas, Pawel Paszek
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immune cells fine tune their responses to infection and inflammatory cues. Here, using live-cell confocal microscopy and mathematical modelling, we investigate interferon-induced JAK-STAT signalling in innate immune macrophages. We demonstrate that t
Externí odkaz:
https://doaj.org/article/f18214bc8b124365b6050d91ca9f4e00
Autor:
Anna Paszek, Małgorzata Kardyńska, James Bagnall, Jarosław Śmieja, David G. Spiller, Piotr Widłak, Marek Kimmel, Wieslawa Widlak, Pawel Paszek
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-21 (2020)
Abstract Background Ability to adapt to temperature changes trough the Heat Shock Response (HSR) pathways is one of the most fundamental and clinically relevant cellular response systems. Heat Shock (HS) affects the signalling and gene expression res
Externí odkaz:
https://doaj.org/article/758c2e93f16345e197d175e447dfcac2
Autor:
Stamatia Papoutsopoulou, Michael D. Burkitt, François Bergey, Hazel England, Rachael Hough, Lorraine Schmidt, David G. Spiller, Michael H. R. White, Pawel Paszek, Dean A. Jackson, Vitor A. P. Martins Dos Santos, Gernot Sellge, D. Mark Pritchard, Barry J. Campbell, Werner Müller, Chris S. Probert
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The heterogeneous nature of inflammatory bowel disease (IBD) presents challenges, particularly when choosing therapy. Activation of the NF-κB transcription factor is a highly regulated, dynamic event in IBD pathogenesis. Using a lentivirus approach,
Externí odkaz:
https://doaj.org/article/d581931c5d434a78a70223703dfa1143
Autor:
Michael J. D. Daniels, Jack Rivers-Auty, Tom Schilling, Nicholas G. Spencer, William Watremez, Victoria Fasolino, Sophie J. Booth, Claire S. White, Alex G. Baldwin, Sally Freeman, Raymond Wong, Clare Latta, Shi Yu, Joshua Jackson, Nicolas Fischer, Violette Koziel, Thierry Pillot, James Bagnall, Stuart M. Allan, Pawel Paszek, James Galea, Michael K. Harte, Claudia Eder, Catherine B. Lawrence, David Brough
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
NSAID-induced analgesia is typically induced by inhibition of COX enzymes. Here the authors show instead that fenamate NSAIDs inhibit the Nlrp3 inflammasome via an effect on volume-regulated anion channel function and also repurpose these drugs for t
Externí odkaz:
https://doaj.org/article/dca8360eb57c4ee588985f6c192c8a0c
Autor:
Antony Adamson, Christopher Boddington, Polly Downton, William Rowe, James Bagnall, Connie Lam, Apolinar Maya-Mendoza, Lorraine Schmidt, Claire V. Harper, David G. Spiller, David A. Rand, Dean A. Jackson, Michael R. H. White, Pawel Paszek
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
In biological systems, timing is often critical to the interpretation of signals that determine cell fate. Here the authors demonstrate how single cells and cellular populations respond dynamically to pulsatile stimulation by TNFα and IL-1β, and su
Externí odkaz:
https://doaj.org/article/1d4f418033bb45d7b771ae8b6ba8118e
Autor:
Małgorzata Kardyńska, Anna Paszek, Jarosław Śmieja, David Spiller, Wiesława Widłak, Michael R H White, Pawel Paszek, Marek Kimmel
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 4, p e1006130 (2018)
Elevated temperature induces the heat shock (HS) response, which modulates cell proliferation, apoptosis, the immune and inflammatory responses. However, specific mechanisms linking the HS response pathways to major cellular signaling systems are not
Externí odkaz:
https://doaj.org/article/49065bcb4cdc48bb8108b4a3a8b1b574