Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Pawel K. Lorkiewicz"'
Autor:
Teresa W.-M. Fan, Jason Winnike, Ahmad Al-Attar, Alexander C. Belshoff, Pawel K. Lorkiewicz, Jin Lian Tan, Min Wu, Richard M. Higashi, Andrew N. Lane
Publikováno v:
Metabolites, Vol 13, Iss 7, p 774 (2023)
Past chemopreventive human trials on dietary selenium supplements produced controversial outcomes. They largely employed selenomethionine (SeM)-based diets. SeM was less toxic than selenite or methylseleninic acid (MSeA) to lung cancer cells. We thus
Externí odkaz:
https://doaj.org/article/d138aeef22d54272a4f32cf81e8a1281
Autor:
Riham R.E. Abouleisa, Lindsey McNally, Abou bakr M. Salama, Sally K. Hammad, Qinghui Ou, Collin Wells, Pawel K. Lorkiewicz, Roberto Bolli, Tamer M.A. Mohamed, Bradford G. Hill
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102094- (2021)
Aims: The coordinated gene and metabolic programs that facilitate cardiomyocyte entry and progression in the cell cycle are poorly understood. The purpose of this study was to identify the metabolic changes that influence myocyte proliferation. Metho
Externí odkaz:
https://doaj.org/article/8a813a80fa3b441081af554c8527baeb
Autor:
Alyssa A. Lombardi, Andrew A. Gibb, Ehtesham Arif, Devin W. Kolmetzky, Dhanendra Tomar, Timothy S. Luongo, Pooja Jadiya, Emma K. Murray, Pawel K. Lorkiewicz, György Hajnóczky, Elizabeth Murphy, Zoltan P. Arany, Daniel P. Kelly, Kenneth B. Margulies, Bradford G. Hill, John W. Elrod
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Myofibroblast differentiation contributes to extracellular matrix remodeling and fibrosis. Here, the authors report that alterations in mitochondrial calcium uptake is essential for metabolic reprogramming and epigenetic signaling for activation of t
Externí odkaz:
https://doaj.org/article/bdc7ccfd4f494ac28c7dce1cb6b33f83
Autor:
Andrew A. Gibb, Anh T. Huynh, Ryan B. Gaspar, Tori L. Ploesch, Alyssa A. Lombardi, Pawel K. Lorkiewicz, Michael P. Lazaropoulos, Ken Bedi, Zolt Arany, Kenneth B. Margulies, Bradford G. Hill, John W. Elrod
Publikováno v:
Journal of Molecular and Cellular Cardiology. 172:78-89
Fibrosis and extracellular matrix remodeling are mediated by resident cardiac fibroblasts (CFs). In response to injury, fibroblasts activate, differentiating into specialized synthetic and contractile myofibroblasts producing copious extracellular ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b078e2812f9c99cf4e925be5a0e1e138
https://doi.org/10.1016/j.yjmcc.2022.08.002
https://doi.org/10.1016/j.yjmcc.2022.08.002
Autor:
Kyle L. Fulghum, Juliette B. Smith, Julia Chariker, Lauren F. Garrett, Kenneth R. Brittian, Pawel K. Lorkiewicz, Lindsey A. McNally, Shizuka Uchida, Steven P. Jones, Bradford G. Hill, Helen E. Collins
Publikováno v:
Am J Physiol Heart Circ Physiol
Fulghum, K L, Smith, J B, Chariker, J, Garrett, L F, Brittian, K R, Lorkiewicz, P, McNally, L A, Uchida, S, Jones, S P, Hill, B G & Collins, H E 2022, ' Metabolic Signatures of Pregnancy-Induced Cardiac Growth ', American Journal of Physiology: Heart and Circulatory Physiology, vol. 323, no. 1, pp. H146-H164 . https://doi.org/10.1152/ajpheart.00105.2022
Fulghum, K L, Smith, J B, Chariker, J, Garrett, L F, Brittian, K R, Lorkiewicz, P, McNally, L A, Uchida, S, Jones, S P, Hill, B G & Collins, H E 2022, ' Metabolic Signatures of Pregnancy-Induced Cardiac Growth ', American Journal of Physiology: Heart and Circulatory Physiology, vol. 323, no. 1, pp. H146-H164 . https://doi.org/10.1152/ajpheart.00105.2022
The goal of this study was to develop an atlas of the metabolic, transcriptional, and proteomic changes that occur with pregnancy in the maternal heart. Timed pregnancy studies in FVB/NJ mice revealed a significant increase in heart size by day 8 of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1758a83bc043dfdf36a85f3f2f5ea8c6
https://pubmed.ncbi.nlm.nih.gov/35622533
https://pubmed.ncbi.nlm.nih.gov/35622533
Autor:
Lane, Teresa W.-M. Fan, Jason Winnike, Ahmad Al-Attar, Alexander C. Belshoff, Pawel K. Lorkiewicz, Jin Lian Tan, Min Wu, Richard M. Higashi, Andrew N.
Publikováno v:
Metabolites; Volume 13; Issue 7; Pages: 774
Past chemopreventive human trials on dietary selenium supplements produced controversial outcomes. They largely employed selenomethionine (SeM)-based diets. SeM was less toxic than selenite or methylseleninic acid (MSeA) to lung cancer cells. We thus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::52479623a25a714a153196810d2cdace
Autor:
Riham R.E. Abouleisa, Abou Bakr M. Salama, Qinghui Ou, Xian-Liang Tang, Mitesh Solanki, Yiru Guo, Yibing Nong, Lindsey McNally, Pawel K. Lorkiewicz, Kamal M. Kassem, Brooke M. Ahern, Krishna Choudhary, Reuben Thomas, Yu Huang, Hamzah R. Juhardeen, Aisha Siddique, Zainab Ifthikar, Sally K. Hammad, Ayman S. Elbaz, Kathryn N. Ivey, Daniel J. Conklin, Jonathan Satin, Bradford G. Hill, Deepak Srivastava, Roberto Bolli, Tamer M.A. Mohamed
Publikováno v:
Circulation, vol 145, iss 17
Circulation
Circulation
Background: The regenerative capacity of the heart after myocardial infarction is limited. Our previous study showed that ectopic introduction of 4 cell cycle factors (4F; CDK1 [cyclin-dependent kinase 1], CDK4 [cyclin-dependent kinase 4], CCNB [cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249a499faef816968a494e25e7f08a68
https://escholarship.org/uc/item/56t1k1cp
https://escholarship.org/uc/item/56t1k1cp
Autor:
Denise S. Tevis, Sharon R. Flores, Brandon M. Kenwood, Deepak Bhandari, Peyton Jacob, Jia Liu, Pawel K. Lorkiewicz, Daniel J. Conklin, Stephen S. Hecht, Maciej L. Goniewicz, Benjamin C. Blount, Víctor R. De Jesús
Publikováno v:
International Journal of Hygiene and Environmental Health. 247:114030
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a32146b1ec1527131c04578470b56bf1
https://doi.org/10.1016/j.ijheh.2022.114030
https://doi.org/10.1016/j.ijheh.2022.114030
Autor:
Rahul Kumar, Sangeet Adhikari, Erin M. Driver, Ted Smith, Aruni Bhatnagar, Pawel K. Lorkiewicz, Zhengzhi Xie, J. David Hoetker, Rolf U. Halden
Publikováno v:
Science of The Total Environment. 845:157008
In this study, we investigated the feasibility of detecting 35 urinary biomarkers of volatile organic compounds (VOCs) exposure in community wastewater. 24-h composited municipal wastewater samples were collected from two communities (n = 8) in the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4196678dffed98d923c1ec7072d6866
https://doi.org/10.1016/j.scitotenv.2022.157008
https://doi.org/10.1016/j.scitotenv.2022.157008
Autor:
Andrew A. Gibb, Pawel K. Lorkiewicz, Yu-Ting Zheng, Xiang Zhang, Aruni Bhatnagar, Steven P. Jones, Bradford G. Hill
Publikováno v:
Biochemical Journal
Although ancillary pathways of glucose metabolism are critical for synthesizing cellular building blocks and modulating stress responses, how they are regulated remains unclear. In the present study, we used radiometric glycolysis assays, [13C6]-gluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe08fc41a9072fd58591d54844fdb49e
https://pubmed.ncbi.nlm.nih.gov/28706006
https://pubmed.ncbi.nlm.nih.gov/28706006