Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Pawel Gajer"'
Autor:
Johanna B. Holm, Michael T. France, Pawel Gajer, Bing Ma, Rebecca M. Brotman, Michelle Shardell, Larry Forney, Jacques Ravel
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-20 (2023)
Abstract Background A Lactobacillus-dominated vaginal microbiome provides the first line of defense against adverse genital tract health outcomes. However, there is limited understanding of the mechanisms by which the vaginal microbiome modulates pro
Externí odkaz:
https://doaj.org/article/d6735ce388314159b937932275107a6e
Publikováno v:
Animal Microbiome, Vol 5, Iss 1, Pp 1-22 (2023)
Abstract Background Nondrug supplement strategies to improve gut health have largely focused on the effects of individual compounds to improve one aspect of gut homeostasis. However, there is no comprehensive assessment of the reproducible effects of
Externí odkaz:
https://doaj.org/article/b864b3fa04754b8fb04ffd070c487983
Autor:
Johanna B. Holm, Michael T. France, Pawel Gajer, Bing Ma, Rebecca M. Brotman, Michelle Shardell, Larry Forney, Jacques Ravel
Publikováno v:
Microbiome, Vol 12, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/653ab3b017be4a0692749e1ae1a64b80
Influence of Hormonal Contraceptive Use and HIV on Cervicovaginal Cytokines and Microbiota in Malawi
Autor:
Lisa B. Haddad, Jennifer H. Tang, Nicole L. Davis, Athena P. Kourtis, Lameck Chinula, Albans Msika, Gerald Tegha, Mina C. Hosseinipour, Julie A. E. Nelson, Marcia M. Hobbs, Pawel Gajer, Jacques Ravel, Kristina De Paris
Publikováno v:
mSphere, Vol 8, Iss 1 (2023)
ABSTRACT Important questions remain on how hormonal contraceptives alter the local immune environment and the microbiota in the female genital tract and how such effects may impact susceptibility to HIV infection. We leveraged samples from a previous
Externí odkaz:
https://doaj.org/article/54a3ebe6495647c4861a154db572d2ed
Autor:
Susan Tuddenham, Pawel Gajer, Anne E. Burke, Catherine Murphy, Sabra L. Klein, Christina A. Stennett, Barbara Wilgus, Jacques Ravel, Khalil G. Ghanem, Rebecca M. Brotman
Publikováno v:
EBioMedicine, Vol 87, Iss , Pp 104407- (2023)
Summary: Background: Bacterial vaginosis (BV), a condition in which vaginal Lactobacillus spp. are in low abundance, is associated with vulvovaginal symptoms, obstetric outcomes and urogenital infections. Recurrent BV is difficult to manage, and emer
Externí odkaz:
https://doaj.org/article/d8f2603361c7469084dd44a679065aa4
Autor:
Bing Ma, Sripriya Sundararajan, Gita Nadimpalli, Michael France, Elias McComb, Lindsay Rutt, Jose M. Lemme-Dumit, Elise Janofsky, Lisa S. Roskes, Pawel Gajer, Li Fu, Hongqiu Yang, Mike Humphrys, Luke J. Tallon, Lisa Sadzewicz, Marcela F. Pasetti, Jacques Ravel, Rose M. Viscardi
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT “Leaky gut,” or high intestinal barrier permeability, is common in preterm newborns. The role of the microbiota in this process remains largely uncharacterized. We employed both short- and long-read sequencing of the 16S rRNA gene and me
Externí odkaz:
https://doaj.org/article/ac1c5db7656449f19104f3a64c3a8c0d
Autor:
Andrea R. Thurman, Jacques Ravel, Pawel Gajer, Mark A. Marzinke, Louise A. Ouattara, Terry Jacot, M. Melissa Peet, Meredith R. Clark, Gustavo F. Doncel
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
BackgroundA relationship between the vaginal microbiota and tenofovir (TFV) concentrations and activity after topical administration has been previously reported.ObjectiveCONRAD A15-138 was a randomized, placebo-controlled Phase I study aimed at char
Externí odkaz:
https://doaj.org/article/d591c8779d9548a1a3b5529774d71d09
Autor:
Michal A. Elovitz, Pawel Gajer, Valerie Riis, Amy G. Brown, Michael S. Humphrys, Johanna B. Holm, Jacques Ravel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Here, Elovitz et al. investigate associations between cervicovaginal microbiota (CVM) and spontaneous preterm birth (sPTB) in a large cohort of African American and non-African American women, and find that CVM and local immune response early in preg
Externí odkaz:
https://doaj.org/article/f079386160224b2f96baee4839409544
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Previous studies have described bacterial vaginosis (BV) as associated with increased cell-shedding from the cervicovaginal epithelium. Cell-shedding in excess of cell-proliferation is thought to decrease epithelial barrier function and increase susc
Externí odkaz:
https://doaj.org/article/20538664138b41f792a73283750ed95e
Autor:
Vonetta L. Edwards, Steven B. Smith, Elias J. McComb, Jeanne Tamarelle, Bing Ma, Michael S. Humphrys, Pawel Gajer, Kathleen Gwilliam, Alison M. Schaefer, Samuel K. Lai, Mishka Terplan, Katrina S. Mark, Rebecca M. Brotman, Larry J. Forney, Patrik M. Bavoil, Jacques Ravel
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT The mechanism(s) by which Lactobacillus-dominated cervicovaginal microbiota provide a barrier to Chlamydia trachomatis infection remain(s) unknown. Here we evaluate the impact of different Lactobacillus spp. identified via culture-independen
Externí odkaz:
https://doaj.org/article/c7ac43892b7246beabc1cea4bec10970