Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Pawel Durek"'
Autor:
Marta Ferreira-Gomes, Yidan Chen, Pawel Durek, Hector Rincon-Arevalo, Frederik Heinrich, Laura Bauer, Franziska Szelinski, Gabriela Maria Guerra, Ana-Luisa Stefanski, Antonia Niedobitek, Annika Wiedemann, Marina Bondareva, Jacob Ritter, Katrin Lehmann, Sebastian Hardt, Christian Hipfl, Sascha Hein, Eberhard Hildt, Mareen Matz, Henrik E. Mei, Qingyu Cheng, Van Duc Dang, Mario Witkowski, Andreia C. Lino, Andrey Kruglov, Fritz Melchers, Carsten Perka, Eva V. Schrezenmeier, Andreas Hutloff, Andreas Radbruch, Thomas Dörner, Mir-Farzin Mashreghi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different activation environments or maturation of their precursors. Here we de
Externí odkaz:
https://doaj.org/article/6afb3ecd327947ce81ffe2bed6522ae5
Autor:
Peter K Jani, Georg Petkau, Yohei Kawano, Uwe Klemm, Gabriela Maria Guerra, Gitta Anne Heinz, Frederik Heinrich, Pawel Durek, Mir-Farzin Mashreghi, Fritz Melchers
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002015 (2023)
Throughout life, hematopoietic stem cells (HSCs), residing in bone marrow (BM), continuously regenerate erythroid/megakaryocytic, myeloid, and lymphoid cell lineages. This steady-state hematopoiesis from HSC and multipotent progenitors (MPPs) in BM c
Externí odkaz:
https://doaj.org/article/f5721978d1074d5487f1c9dc30066fbd
Autor:
Ronja Mothes, Anna Pascual-Reguant, Ralf Koehler, Juliane Liebeskind, Alina Liebheit, Sandy Bauherr, Lars Philipsen, Carsten Dittmayer, Michael Laue, Regina von Manitius, Sefer Elezkurtaj, Pawel Durek, Frederik Heinrich, Gitta A. Heinz, Gabriela M. Guerra, Benedikt Obermayer, Jenny Meinhardt, Jana Ihlow, Josefine Radke, Frank L. Heppner, Philipp Enghard, Helena Stockmann, Tom Aschman, Julia Schneider, Victor M. Corman, Leif E. Sander, Mir-Farzin Mashreghi, Thomas Conrad, Andreas C. Hocke, Raluca A. Niesner, Helena Radbruch, Anja E. Hauser
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Infection with SARS-CoV-2 has been linked with substantive inflammation, lung pathology and development of COVID-19. Here the authors spatially associate CCL18 and CCL21 in distinct tissue niches with lung pathology of severe COVID-19.
Externí odkaz:
https://doaj.org/article/1b2247b6d5234d329b89d09ddd2a8d84
Autor:
Christopher M. Skopnik, René Riedel, Richard K. Addo, Gitta Anne Heinz, Frederik Heinrich, Kazuhito Honjo, Pawel Durek, Philipp Enghard, Mir-Farzin Mashreghi, Andreas Radbruch, Hiromi Kubagawa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/80337a67e08f4afe87d3f3623dc97933
Autor:
Maren Schmiester, René Maier, René Riedel, Pawel Durek, Marco Frentsch, Stefan Kolling, Mir-Farzin Mashreghi, Robert Jenq, Liangliang Zhang, Christine B. Peterson, Lars Bullinger, Hyun-Dong Chang, Il-Kang Na
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Modulation of commensal gut microbiota is increasingly recognized as a promising strategy to reduce mortality in patients with malignant diseases, but monitoring for dysbiosis is generally not routine clinical practice due to equipment, expertise and
Externí odkaz:
https://doaj.org/article/131978702d9042d08878dcd1673b4c7e
Autor:
Ping Shen, Peihua Wu, Tazio Maleitzke, Marie-Jacqueline Reisener, Gitta A. Heinz, Frederik Heinrich, Pawel Durek, Clemens Gwinner, Tobias Winkler, Matthias Pumberger, Carsten Perka, Mir-Farzin Mashreghi, Max Löhning
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
The isolation of chondrocytes from human articular cartilage for single-cell RNA sequencing requires extensive and prolonged tissue digestion at 37 C. Modulations of the transcriptional activity likely take place during this period such that the tran
Externí odkaz:
https://doaj.org/article/af3dbe3f9f3f4064bcec58eb8ecff696
Autor:
Marta Ferreira-Gomes, Andrey Kruglov, Pawel Durek, Frederik Heinrich, Caroline Tizian, Gitta Anne Heinz, Anna Pascual-Reguant, Weijie Du, Ronja Mothes, Chaofan Fan, Stefan Frischbutter, Katharina Habenicht, Lisa Budzinski, Justus Ninnemann, Peter K. Jani, Gabriela Maria Guerra, Katrin Lehmann, Mareen Matz, Lennard Ostendorf, Lukas Heiberger, Hyun-Dong Chang, Sandy Bauherr, Marcus Maurer, Günther Schönrich, Martin Raftery, Tilmann Kallinich, Marcus Alexander Mall, Stefan Angermair, Sascha Treskatsch, Thomas Dörner, Victor Max Corman, Andreas Diefenbach, Hans-Dieter Volk, Sefer Elezkurtaj, Thomas H. Winkler, Jun Dong, Anja Erika Hauser, Helena Radbruch, Mario Witkowski, Fritz Melchers, Andreas Radbruch, Mir-Farzin Mashreghi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Our understanding on the humoral immunity induced by SARS-CoV-2 is still lacking. Here the authors analyze B cell responses at the single cell level to find that, in severe COVID-19 patients, plasmablasts shift from IFN to TGFβ instruction to produc
Externí odkaz:
https://doaj.org/article/58a67a60b8ae4622829438abe4d63e7c
Autor:
René Riedel, Richard Addo, Marta Ferreira-Gomes, Gitta Anne Heinz, Frederik Heinrich, Jannis Kummer, Victor Greiff, Daniel Schulz, Cora Klaeden, Rebecca Cornelis, Ulrike Menzel, Stefan Kröger, Ulrik Stervbo, Ralf Köhler, Claudia Haftmann, Silvia Kühnel, Katrin Lehmann, Patrick Maschmeyer, Mairi McGrath, Sandra Naundorf, Stefanie Hahne, Özen Sercan-Alp, Francesco Siracusa, Jonathan Stefanowski, Melanie Weber, Kerstin Westendorf, Jakob Zimmermann, Anja E. Hauser, Sai T. Reddy, Pawel Durek, Hyun-Dong Chang, Mir-Farzin Mashreghi, Andreas Radbruch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Memory B cells are important for protecting the host from pathogen rechallenge, but their properties and locations remain ill-defined. Here the authors show, using single-cell transcriptomics and repertoire analyses, that mouse spleen and bone marrow
Externí odkaz:
https://doaj.org/article/d1c99a7f8c7f4d7ab186f53fdfc1db4e
Autor:
Jennifer Pfeil, Mario Simonetti, Uta Lauer, Bianca von Thülen, Pawel Durek, Christina Poulsen, Justyna Pawlowska, Matthias Kröger, Ralf Krähmer, Frank Leenders, Ute Hoffmann, Alf Hamann
Publikováno v:
Therapeutic Advances in Chronic Disease, Vol 12 (2021)
Background: Therapeutic treatment options for chronic autoimmune disorders such as multiple sclerosis (MS) rely largely on the use of non-specific immunosuppressive drugs, which are not able to cure the disease. Presently, approaches to induce antige
Externí odkaz:
https://doaj.org/article/a537fda790ce435eb4d99d3b231f5ab9
Autor:
Jennifer Pfeil, Mario Simonetti, Uta Lauer, Rudolf Volkmer, Bianca von Thülen, Pawel Durek, Ralf Krähmer, Frank Leenders, Alf Hamann, Ute Hoffmann
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Current treatments for autoimmune disorders rely on non-specific immunomodulatory and global immunosuppressive drugs, which show a variable degree of efficiency and are often accompanied by side effects. In contrast, strategies aiming at inducing ant
Externí odkaz:
https://doaj.org/article/d9cbc032df4a4db2bc473021cefb52f8