Výsledky vyhledávání - "Pawel Bonczkowski"

Akademický článek

Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs

Autor: Eva Malatinkova, Ward De Spiegelaere, Pawel Bonczkowski, Maja Kiselinova, Karen Vervisch, Wim Trypsteen, Margaret Johnson, Chris Verhofstede, Danny de Looze, Charles Murray, Sabine Kinloch-de Loes, Linos Vandekerckhove

Publikováno v: eLife, Vol 4 (2015)

Persistent reservoirs remain the major obstacles to achieve an HIV-1 cure. Prolonged early antiretroviral therapy (ART) may reduce the extent of reservoirs and allow for virological control after ART discontinuation. We compared HIV-1 reservoirs in a

Externí odkaz: https://doaj.org/article/36943e574147408383d7ca3d3e4e7a23

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Akademický článek

Comparison of methods for in-house screening of HLA-B*57:01 to prevent abacavir hypersensitivity in HIV-1 care.

Autor: Ward De Spiegelaere, Jan Philippé, Karen Vervisch, Chris Verhofstede, Eva Malatinkova, Maja Kiselinova, Wim Trypsteen, Pawel Bonczkowski, Dirk Vogelaers, Steven Callens, Jean Ruelle, Kabamba Kabeya, Stephane De Wit, Petra Van Acker, Vicky Van Sandt, Marie-Paule Emonds, Paul Coucke, Erica Sermijn, Linos Vandekerckhove

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0123525 (2015)

Abacavir is a nucleoside reverse transcriptase inhibitor used as part of combination antiretroviral therapy in HIV-1-infected patients. Because this drug can cause a hypersensitivity reaction that is correlated with the presence of the HLA-B*57:01 al

Externí odkaz: https://doaj.org/article/e34e992d508a4e7ca2e338a8729d4f0b

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Modeling HIV-1 Latency in Primary T Cells Using a Replication-Competent Virus

Autor: Camille L. Novis, Ward De Spiegelaere, Wim Trypsteen, Eva Malatinkova, Laura J. Martins, Alberto Bosque, Vicente Planelles, Adam M. Spivak, Linos Vanderkerckhove, Ana Beatriz DePaula-Silva, Pawel Bonczkowski

Publikováno v: AIDS Research and Human Retroviruses. 32:187-193

HIV-1 latently infected cells in vivo can be found in extremely low frequencies. Therefore, in vitro cell culture models have been used extensively for the study of HIV-1 latency. Often, these in vitro systems utilize defective viruses. Defective vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb10913a836432e56645162e6d1f53d
https://doi.org/10.1089/aid.2015.0106

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ddpcRquant: threshold determination for single channel droplet digital PCR experiments

Autor: Ward De Spiegelaere, Jan De Neve, Eva Malatinkova, Olivier Thas, Wim Trypsteen, Maja Kiselinova, Linos Vandekerckhove, Matthijs Vynck, Karen Vervisch, Pawel Bonczkowski

Publikováno v: Analytical and Bioanalytical Chemistry. 407:5827-5834

Digital PCR is rapidly gaining interest in the field of molecular biology for absolute quantification of nucleic acids. However, the first generation of platforms still needs careful validation and requires a specific methodology for data analysis to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596b6abd88811d7c8a3bf18c7c0c9fb0
https://doi.org/10.1007/s00216-015-8773-4

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Protein expression from unintegrated HIV-1 DNA introduces bias in primary in vitro post-integration latency models

Autor: Renate Koenig, Ward De Spiegelaere, Eva Malatinkova, Zora Melkova, Alexandra Borch, Marie-Angélique De Scheerder, Pawel Bonczkowski, Linos Vandekerckhove

Publikováno v: SCIENTIFIC REPORTS
Scientific Reports

To understand the persistence of latently HIV-1 infected cells in virally suppressed infected patients, a number of in vitro models of HIV latency have been developed. In an attempt to mimic the in vivo situation as closely as possible, several model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70eb8346f183adebd1b1bebf33489f66
https://doi.org/10.1038/srep38329

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Accurate Quantification of Episomal HIV-1 Two-Long Terminal Repeat Circles by Use of Optimized DNA Isolation and Droplet Digital PCR

Autor: Eva Malatinkova, Karen Vervisch, Pawel Bonczkowski, Bruno Verhasselt, Wim Trypsteen, Jolien Vermeire, Maja Kiselinova, Peter Messiaen, Ward De Spiegelaere, Linos Vandekerckhove

Publikováno v: Journal of Clinical Microbiology. 53:699-701

Episomal HIV-1 two-long terminal repeat (2-LTR) circles are considered markers for ongoing viral replication. Two sample processing procedures were compared to accurately quantify 2-LTR in patients by using droplet digital PCR (ddPCR). Here, we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef60234c45b80e50dd6cdeefe4be121
https://doi.org/10.1128/jcm.03087-14

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Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs

Autor: Chris Verhofstede, Karen Vervisch, Charles Murray, Eva Malatinkova, Pawel Bonczkowski, Linos Vandekerckhove, Ward De Spiegelaere, Margaret Johnson, Danny De Looze, Sabine Kinloch-de Loes, Wim Trypsteen, Maja Kiselinova

Publikováno v: eLife, Vol 4 (2015)
ELIFE
eLife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aad05bda1efdab3593e0c6ee7b88afd
https://elifesciences.org/articles/09115

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