Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation

Autor: Chiara Angiolilli, Pawel A. Kabala, Aleksander M. Grabiec, Marzia Rossato, Wi S. Lai, Gianluca Fossati, Paolo Mascagni, Christian Steinkühler, Perry J. Blackshear, Kris A. Reedquist, Dominique L. Baeten, Timothy R. D. J. Radstake

Publikováno v: Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-13 (2018)

Abstract Background Histone deacetylase inhibitors (HDACi) suppress cytokine production in immune and stromal cells of patients with rheumatoid arthritis (RA). Here, we investigated the effects of the HDACi givinostat (ITF2357) on the transcriptional

Externí odkaz: https://doaj.org/article/83d2e7378e224af4803dfe205aa1bd4a

BET bromodomain inhibition reduces maturation and enhances tolerogenic properties of human and mouse dendritic cells

Autor: Rab K. Prinjha, Paul P. Tak, Wouter J. de Jonge, Francisca W. Hilbers, Kris A. Reedquist, David F. Tough, Pawel A. Kabala, Matthew J Bell, Eleonora Reginato, Chris Patten, Ronald Schilderink, Inmaculada Rioja

Publikováno v: Molecular immunology, 79, 66-76. Elsevier Limited

Transcription of inflammatory genes is tightly regulated by acetylation and deacetylation of histone tails. An inhibitor of the acetylated-lysine reader bromodomain and extra-terminal domain (BET) proteins, I-BET151, is known to counteract the induct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b75c79448d8bb30423c130c2f2156a

The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts

Autor: Kerstin Klein, Pawel A Kabala, Aleksander M Grabiec, Renate E Gay, Christoph Kolling, Lih-Ling Lin, Steffen Gay, Paul P Tak, Rab K Prinjha, Caroline Ospelt, Kris A Reedquist

Publikováno v: Annals of the rheumatic diseases, 75(2), 422-429. BMJ Publishing Group

Objective To investigate the effects of BET bromodomain protein inhibition on inflammatory activation and functional properties of rheumatoid arthritis synovial fibroblasts (RASF). Methods The expression of the BET bromodomain proteins BRD2, BRD3 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6a114b5fe8b61c88948391844d5b61
https://doi.org/10.1136/annrheumdis-2014-205809

Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes

Autor: Bradley S. Ferguson, Timothy A. McKinsey, Paolo Mascagni, Samuel Garcia, Paul P. Tak, Pawel A. Kabala, Kris A. Reedquist, Gianluca Fossati, Iris M. van Baarsen, Chiara Angiolilli, Beatriz Malvar Fernandez, Aleksander M. Grabiec, Dominique Baeten

Publikováno v: Angiolilli, C, Kabala, P A, Grabiec, A, Van Baarsen, I M, Ferguson, B S, García, S, Malvar Fernandez, B, McKinsey, T A, Tak, P P, Fossati, G, Mascagni, P, Baeten, D L & Reedquist, K A 2016, ' Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes ', Annals of the rheumatic diseases, vol. 76 . https://doi.org/10.1136/annrheumdis-2015-209064
Annals of the rheumatic diseases, 76(1), 277-285. BMJ Publishing Group
Annals of the Rheumatic Diseases

ObjectivesNon-selective histone deacetylase (HDAC) inhibitors (HDACi) have demonstrated anti-inflammatory properties in both in vitro and in vivo models of rheumatoid arthritis (RA). Here, we investigated the potential contribution of specific class

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8895cab1f685a8ee1db74c06b2eb47
https://ruj.uj.edu.pl/xmlui/handle/item/54855

OP0192 Sirtuin Deacetylase 2 Inhibition Suppresses Inflammatory Activation of Rheumatoid Arthritis Fibroblast-Like Synoviocytes and IFN-Γ–Differentiated Macrophages

Autor: Dominique Baeten, F. Husseini Shirazi, E. Mohammadi, P.P. Tak, Pawel A. Kabala, Chiara Angiolilli, Kris A. Reedquist

Publikováno v: Annals of the Rheumatic Diseases. 73:135.1-135

Background Rheumatoid arthritis (RA) is characterized by proliferation of synovial fibroblasts (FLS), activation of these cells by synovial macrophages (Mϕ), and production of pro-inflammatory proteins. As genetic backgrounds do not completely expla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6769b99ec3529b2d236ef02054992dec
https://doi.org/10.1136/annrheumdis-2014-eular.4012