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Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103105- (2024)
Summary: Cells, even from the same line, can maintain heterogeneity in metabolic activity. Here, we present a protocol, adapted for fluorescence-activated cell sorting (FACS), that separates resuspended cells according to their metabolic rate. We des
Externí odkaz:
https://doaj.org/article/cf9fba7545ab4a3ab4650f0bfd6d88cc
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113612- (2024)
Summary: Malignancy is enabled by pro-growth mutations and adequate energy provision. However, global metabolic activation would be self-terminating if it depleted tumor resources. Cancer cells could avoid this by rationing resources, e.g., dynamical
Externí odkaz:
https://doaj.org/article/719b9f92f76949c4ac5e60ab238e5b03
Publikováno v:
The Journal of Physiology. 593:5035-5035
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55b082f5c6eef6879011629bead3d0f
https://doi.org/10.1113/jp271240
https://doi.org/10.1113/jp271240
Autor:
Shonagh Russell, Liping Xu, Yoonseok Kam, Dominique Abrahams, Bryce Ordway, Alex S. Lopez, Marilyn M. Bui, Joseph Johnson, Tamir Epstein, Epifanio Ruiz, Mark C. Lloyd, Pawel Swietach, Daniel Verduzco, Jonathan Wojtkowiak, Robert J. Gillies
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-20 (2022)
Abstract Introduction Aggressive cancers commonly ferment glucose to lactic acid at high rates, even in the presence of oxygen. This is known as aerobic glycolysis, or the “Warburg Effect.” It is widely assumed that this is a consequence of the u
Externí odkaz:
https://doaj.org/article/c08b6bd921534c2bac3f3262ad7ecba1
Autor:
Johanna Michl, Stefania Monterisi, Bobby White, Wiktoria Blaszczak, Alzbeta Hulikova, Gulnar Abdullayeva, Esther Bridges, Zinan Yin, Walter F. Bodmer, Pawel Swietach
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112601- (2023)
Summary: Acidic environments reduce the intracellular pH (pHi) of most cells to levels that are sub-optimal for growth and cellular functions. Yet, cancers maintain an alkaline cytoplasm despite low extracellular pH (pHe). Raised pHi is thought to be
Externí odkaz:
https://doaj.org/article/fa74c4cb09b5443a9fcec040cffeaf11
Autor:
Stefania Monterisi, Johanna Michl, Alzbeta Hulikova, Jana Koth, Esther M Bridges, Amaryllis E Hill, Gulnar Abdullayeva, Walter F Bodmer, Pawel Swietach
Publikováno v:
eLife, Vol 11 (2022)
Growth of cancer cells in vitro can be attenuated by genetically inactivating selected metabolic pathways. However, loss-of-function mutations in metabolic pathways are not negatively selected in human cancers, indicating that these genes are not ess
Externí odkaz:
https://doaj.org/article/6873e0339c734b01bab661f7fa921019
Autor:
Hao Wu, Veronica Estrella, Matthew Beatty, Dominique Abrahams, Asmaa El-Kenawi, Shonagh Russell, Arig Ibrahim-Hashim, Dario Livio Longo, Yana K. Reshetnyak, Anna Moshnikova, Oleg A. Andreev, Kimberly Luddy, Mehdi Damaghi, Krithika Kodumudi, Smitha R. Pillai, Pedro Enriquez-Navas, Shari Pilon-Thomas, Pawel Swietach, Robert J. Gillies
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
T-cell activation primarily occurs in the lymph nodes, highly organized and specialized secondary lymphoid organs. Here the authors show that the acidic extracellular pH in lymph node paracortical zones limits cytokine production by effector T-cells,
Externí odkaz:
https://doaj.org/article/8a725d35fbca44839f00a263e2a935bc
Autor:
Johanna Michl, Yunyi Wang, Stefania Monterisi, Wiktoria Blaszczak, Ryan Beveridge, Esther M. Bridges, Jana Koth, Walter F. Bodmer, Pawel Swietach
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110493- (2022)
Summary: Unlike most cell types, many cancer cells survive at low extracellular pH (pHe), a chemical signature of tumors. Genes that facilitate survival under acid stress are therefore potential targets for cancer therapies. We performed a genome-wid
Externí odkaz:
https://doaj.org/article/696d8f39d93a4311848ebb92e14a06d8
Autor:
Killian Donovan, Athinoula Meli, Francesca Cendali, Kyung Chan Park, Rebecca Cardigan, Simon Stanworth, Stuart McKechnie, Angelo D’Alessandro, Peter A. Smethurst, Pawel Swietach
Publikováno v:
Haematologica, Vol 107, Iss 1 (2021)
Externí odkaz:
https://doaj.org/article/c6e7b3b938224a8d8cb46474afd09acd