Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Pawel, Dobrzyn"'
Autor:
Marcin Wolosiewicz, Volodymyr V. Balatskyi, Monika K. Duda, Anna Filip, James M. Ntambi, Viktor O. Navrulin, Pawel Dobrzyn
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 9, Pp 100612- (2024)
Stearoyl-CoA desaturase (SCD) is a lipogenic enzyme that catalyzes formation of the first double bond in the carbon chain of saturated fatty acids. Four isoforms of SCD have been identified in mice, the most poorly characterized of which is SCD4, whi
Externí odkaz:
https://doaj.org/article/13484812e5d74bed8a306b7a8edacb15
Autor:
Ruslan B. Strutynskyi PhD, DSc, Nataliіa A. Strutynska PhD, Oksana O. Piven PhD, DSc, Lidiia A. Mys PhD, Yulia V. Goshovska PhD, Raisa A. Fedichkina PhD, Iryna Y. Okhai (postgraduate), Vladyslav R. Strutynskyi PhD student, Victor E. Dosenko MD, PhD, DSc, Pawel Dobrzyn PhD, DSc, Vadim F. Sagach MD, PhD, DSc
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics, Vol 28 (2023)
Background: The aging process is accompanied by the weakening of the protective systems of the organism, in particular by the decrease in the expression of ATP-sensitive potassium (K ATP ) channels and in the synthesis of H 2 S. The aim of our work w
Externí odkaz:
https://doaj.org/article/c5820cb42bdc42d884adb704b107db9e
Publikováno v:
Cells, Vol 11, Iss 19, p 3032 (2022)
Disturbances in cardiac lipid metabolism are associated with the development of cardiac hypertrophy and heart failure. Spontaneously hypertensive rats (SHRs), a genetic model of primary hypertension and pathological left ventricular (LV) hypertrophy,
Externí odkaz:
https://doaj.org/article/fe2ad4103a224a90aedfaf125156c146
Autor:
Adrian Sowka, Pawel Dobrzyn
Publikováno v:
Cells, Vol 10, Iss 6, p 1485 (2021)
Studies of adipose tissue biology have demonstrated that adipose tissue should be considered as both passive, energy-storing tissue and an endocrine organ because of the secretion of adipose-specific factors, called adipokines. Adiponectin is a well-
Externí odkaz:
https://doaj.org/article/846a66e837634c019d8d2eb54ec7cdf8
Autor:
Yulia V. Goshovska, Raisa A. Fedichkina, Volodymyr V. Balatskyi, Oksana O. Piven, Pawel Dobrzyn, Vadym F. Sagach
Publikováno v:
Life, Vol 11, Iss 7, p 631 (2021)
Glutathione (GSH) is essential for antioxidant defence, and its depletion is associated with tissue damage during cardiac ischemia-reperfusion (I/R). GSH is synthesized by the glutamate-cysteine ligase enzyme (GCL) from L-cysteine, which alternativel
Externí odkaz:
https://doaj.org/article/85dd42d5e8ce4e5f9c669fe9b560af82
Autor:
Volodymyr V. Balatskyi, Oksana L. Palchevska, Lina Bortnichuk, Ana-Maria Gan, Anna Myronova, Larysa L. Macewicz, Viktor O. Navrulin, Lesya V. Tumanovska, Adam Olichwier, Pawel Dobrzyn, Oksana O. Piven
Publikováno v:
Life, Vol 10, Iss 12, p 357 (2020)
The role of canonical Wnt signaling in metabolic regulation and development of physiological cardiac hypertrophy remains largely unknown. To explore the function of β-catenin in the regulation of cardiac metabolism and physiological cardiac hypertro
Externí odkaz:
https://doaj.org/article/36c8f4c06c47434da057c1e6a569c161
Autor:
Ines C. M. Simoes, Agnieszka Karkucinska-Wieckowska, Justyna Janikiewicz, Sylwia Szymanska, Maciej Pronicki, Pawel Dobrzyn, Michal Dabrowski, Agnieszka Dobrzyn, Paulo J. Oliveira, Hans Zischka, Yaiza Potes, Mariusz R. Wieckowski
Publikováno v:
Antioxidants, Vol 9, Iss 10, p 995 (2020)
Nonalcoholic fatty liver disease (NAFLD) is characterized by the development of steatosis, which can ultimately compromise liver function. Mitochondria are key players in obesity-induced metabolic disorders; however, the distinct role of hypercaloric
Externí odkaz:
https://doaj.org/article/19864496d3dd43d88c771bc5876e8caf
Autor:
Justyna Janikiewicz, Katarzyna Hanzelka, Anna Dziewulska, Kamil Kozinski, Pawel Dobrzyn, Tytus Bernas, Agnieszka Dobrzyn
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 10, Pp 1901-1911 (2015)
Autophagy is indispensable for the proper architecture and flawless functioning of pancreatic β-cells. A growing body of evidence indicates reciprocal communication between autophagic pathways, apoptosis, and intracellular lipids. The way in which e
Externí odkaz:
https://doaj.org/article/887b0013495349b493474a9c2f99e73e
Publikováno v:
Acta physiologica (Oxford, England).
The WNT/β-catenin pathway is a master regulator of cardiac development and growth, and its activity is low in healthy adult hearts. However, even this low activity is essential for maintaining normal heart function. Acute activation of the WNT/β-ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486183b00732004eae176cd28e5f3986
https://pubmed.ncbi.nlm.nih.gov/36599355
https://pubmed.ncbi.nlm.nih.gov/36599355
Autor:
Vladimir Vartanian, Jana Tumova, Pawel Dobrzyn, Agnieszka Dobrzyn, Yusaku Nakabeppu, R Stephen Lloyd, Harini Sampath
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181687 (2017)
Oxidative stress resulting from endogenous and exogenous sources causes damage to cellular components, including genomic and mitochondrial DNA. Oxidative DNA damage is primarily repaired via the base excision repair pathway that is initiated by DNA g
Externí odkaz:
https://doaj.org/article/347458e1681f455fa3b6730bea7caa3e