Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Pawat, Laohamonthonkul"'
Autor:
Lianne I. M. Lansink, Oliver P. Skinner, Jessica A. Engel, Hyun Jae Lee, Megan S. F. Soon, Cameron G. Williams, Arya SheelaNair, Clara P. S. Pernold, Pawat Laohamonthonkul, Jasmin Akter, Thomas Stoll, Michelle M. Hill, Arthur M. Talman, Andrew Russell, Mara Lawniczak, Xiaoxiao Jia, Brendon Chua, Dovile Anderson, Darren J. Creek, Miles P. Davenport, David S. Khoury, Ashraful Haque
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Maturation rates of malaria parasites within red blood cells (RBCs) can be influenced by host nutrient status and circadian rhythm; whether host inflammatory responses can also influence maturation remains less clear. Here, we observed that
Externí odkaz:
https://doaj.org/article/ad892e1e2d52402895cf3b6d1a593a65
Autor:
Annemarie Steiner, Katja Hrovat-Schaale, Ignazia Prigione, Chien-Hsiung Yu, Pawat Laohamonthonkul, Cassandra R. Harapas, Ronnie Ren Jie Low, Dominic De Nardo, Laura F. Dagley, Michael J. Mlodzianoski, Kelly L. Rogers, Thomas Zillinger, Gunther Hartmann, Michael P. Gantier, Marco Gattorno, Matthias Geyer, Stefano Volpi, Sophia Davidson, Seth L. Masters
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Mutations in the coatomer complex I can result in endoplasmic reticulum stress and inflammatory consequences. Here authors define aberrant activation of the STING immunosensing pathway in a disturbed coatmer complex context and the therapeutic modula
Externí odkaz:
https://doaj.org/article/30fa6bbd687e41a1bd2b9d85bd46d601
Autor:
Jasmin Akter, David S Khoury, Rosemary Aogo, Lianne I M Lansink, Arya SheelaNair, Bryce S Thomas, Pawat Laohamonthonkul, Clara P S Pernold, Matthew W A Dixon, Megan S F Soon, Lily G Fogg, Jessica A Engel, Trish Elliott, Ismail Sebina, Kylie R James, Deborah Cromer, Miles P Davenport, Ashraful Haque
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007599 (2019)
Plasmodium parasites invade and multiply inside red blood cells (RBC). Through a cycle of maturation, asexual replication, rupture and release of multiple infective merozoites, parasitised RBC (pRBC) can reach very high numbers in vivo, a process tha
Externí odkaz:
https://doaj.org/article/39969c1b306b4b6d93575b28a7501a6c
Autor:
Cassandra R. Harapas, Kim S. Robinson, Kenneth Lay, Jasmine Wong, Ricardo Moreno Traspas, Nasrin Nabavizadeh, Annick Rass-Rothschild, Bertrand Boisson, Scott B. Drutman, Pawat Laohamonthonkul, Devon Bonner, Jingwei Rachel Xiong, Mark D. Gorrell, Sophia Davidson, Chien-Hsiung Yu, Mark D. Fleming, Jonas Gudera, Jerry Stein, Miriam Ben-Harosh, Emily Groopman, Akiko Shimamura, Hannah Tamary, Hülya Kayserili, Nevin Hatipoğlu, Jean-Laurent Casanova, Jonathan A. Bernstein, Franklin L. Zhong, Seth L. Masters, Bruno Reversade
Publikováno v:
Sci Immunol
Dipeptidyl peptidase 9 (DPP9) is a direct inhibitor of NLRP1, but how it affects inflammasome regulation in vivo is not yet established. Here, we report three families with immune-associated defects, poor growth, pancytopenia, and skin pigmentation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ee3ba9502fc466d9b6603e4fdcf190
https://pubmed.ncbi.nlm.nih.gov/36112693
https://pubmed.ncbi.nlm.nih.gov/36112693
Autor:
Sophia Davidson, Chien-Hsiung Yu, Annemarie Steiner, Frédéric Ebstein, Paul J. Baker, Valentina Jarur-Chamy, Katja Hrovat Schaale, Pawat Laohamonthonkul, Klara Kong, Dale J. Calleja, Cassandra R. Harapas, Katherine R. Balka, Jacob Mitchell, Jacob T. Jackson, Niall D. Geoghegan, Fiona Moghaddas, Kelly L. Rogers, Katrin D. Mayer-Barber, Adriana A. De Jesus, Dominic De Nardo, Benjamin T. Kile, Anthony J. Sadler, M. Cecilia Poli, Elke Krüger, Raphaela Goldbach Mansky, Seth L. Masters
Publikováno v:
Science Immunology. 7
Proteasome dysfunction can lead to autoinflammatory disease associated with elevated type I interferon (IFN-αβ) and NF-κB signaling; however, the innate immune pathway driving this is currently unknown. Here, we identified protein kinase R (PKR) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4eb9ee56088af3a11d074b259107a13
https://doi.org/10.1126/sciimmunol.abi6763
https://doi.org/10.1126/sciimmunol.abi6763
Autor:
Cassandra R. Harapas, Elina Idiiatullina, Mahmoud Al-Azab, Katja Hrovat-Schaale, Thomas Reygaerts, Annemarie Steiner, Pawat Laohamonthonkul, Sophia Davidson, Chien-Hsiung Yu, Lee Booty, Seth L. Masters
Publikováno v:
Nature reviews. Immunology. 22(9)
A cell is delimited by numerous borders that define specific organelles. The walls of some organelles are particularly robust, such as in mitochondria or endoplasmic reticulum, but some are more fluid such as in phase-separated stress granules. Eithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2827b6c2f6d71262231beb70dd21ed7
https://pubmed.ncbi.nlm.nih.gov/35197578
https://pubmed.ncbi.nlm.nih.gov/35197578
Autor:
Jasmin Akter, Clara P. S. Pernold, Mara K. N. Lawniczak, Arthur M. Talman, Thomas Stoll, Andrew Russell, Lianne I. M. Lansink, Michelle M. Hill, David S. Khoury, Pawat Laohamonthonkul, Cameron G. Williams, Arya SheelaNair, Jessica A. Engel, Hyun Jae Lee, Megan S. F. Soon, Miles P. Davenport, Ashraful Haque
Maturation rate of malaria parasites within red blood cells (RBC) can be influenced by host nutrient status or circadian rhythm. Here, we observed in mice that systemic host inflammation, induced by lipopolysaccharide (LPS) conditioning or ongoing ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0ff5233b339509181ddae6993010a4b
https://doi.org/10.1101/2021.08.18.456784
https://doi.org/10.1101/2021.08.18.456784
Autor:
Pawat Laohamonthonkul, Gorrell M, Kim S. Robinson, Hatipoglu N, Jean-Laurent Casanova, Wong J, Chien-Hsiung Yu, Jon A Bernstein, Scott Drutman, Cassandra R. Harapas, Hülya Kayserili, Reversade B, Franklin L. Zhong, Sophia Davidson, Raas-Rothschild A, Seth L. Masters, Lay K, Devon Bonner, Bertrand Boisson
Dipeptidyl peptidase 9 (DPP9) is a direct inhibitor of NLRP1, but how it impacts inflammasome regulation in vivo is not yet established. Here, we report two families with immune-associated defects, skin pigmentation abnormalities and neurological def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfc77e3a8fb7f51f02d60976e3631f4d
https://doi.org/10.1101/2021.01.31.21250067
https://doi.org/10.1101/2021.01.31.21250067
Autor:
Annemarie Steiner, Katja Hrovat-Schaale, Ignazia Prigione, Chien-Hsiung Yu, Pawat Laohamonthonkul, Cassandra R. Harapas, Ronnie Ren Jie Low, Dominic De Nardo, Laura F. Dagley, Michael J. Mlodzianoski, Kelly L. Rogers, Thomas Zillinger, Gunther Hartmann, Michael P. Gantier, Marco Gattorno, Matthias Geyer, Stefano Volpi, Sophia Davidson, Seth L. Masters
Publikováno v:
Nature communications. 13(1)
Coatomer complex I (COPI) mediates retrograde vesicular trafficking from Golgi to the endoplasmic reticulum (ER) and within Golgi compartments. Deficiency in subunit alpha causes COPA syndrome and is associated with type I IFN signalling, although th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c532921ca6f5fc6a51c804f242ae02
https://pubmed.ncbi.nlm.nih.gov/35484149
https://pubmed.ncbi.nlm.nih.gov/35484149
Autor:
Marco Gattorno, Laura F. Dagley, Sophia Davidson, Seth L. Masters, Annemarie Steiner, Dominic De Nardo, Katja Hrovat Schaale, Stefano Volpi, Chien-Hsiung Yu, Cassandra R. Harapas, Ignazia Prigione, Michael P. Gantier, Pawat Laohamonthonkul
COPA syndrome is caused by loss-of-function mutations in the COP-α subunit of coatomer protein complex I (COPI), which participates in retrograde vesicular trafficking of proteins from the Golgi to the endoplasmic reticulum (ER). Disease manifests e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d3a7732c193093452d27a4ffa799d3a
https://doi.org/10.1101/2020.07.09.194399
https://doi.org/10.1101/2020.07.09.194399