Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Pawanrat Tangseefa"'
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101890- (2024)
Background & aims: Genome-wide studies have identified three missense variants in the human gene ACVR1C, encoding the TGF-β superfamily receptor ALK7, that correlate with altered waist-to-hip ratio adjusted for body mass index (WHR/BMI), a measure o
Externí odkaz:
https://doaj.org/article/b606558e3d5f40fcbcd32be3190a7662
Autor:
Alanah L. Bradey, Stephen Fitter, Jvaughn Duggan, Vicki Wilczek, Connor M. D. Williams, Emma AJ. Cheney, Jacqueline E. Noll, Pawanrat Tangseefa, Vasilios Panagopoulos, Andrew C. W. Zannettino
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Multiple myeloma (MM) is an incurable haematological malignancy, caused by the uncontrolled proliferation of plasma cells within the bone marrow (BM). Obesity is a known risk factor for MM, however, few studies have investigated the potentia
Externí odkaz:
https://doaj.org/article/6d46703cea084e25a8d12c7d74c265bf
Autor:
Pawanrat Tangseefa, Sally K. Martin, Peck Yin Chin, James Breen, Chui Yan Mah, Paul A. Baldock, Gary A. Wittert, Amanda J. Page, Christopher G. Proud, Stephen Fitter, Andrew C. W. Zannettino
Publikováno v:
Bone Research, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract Overnutrition causes hyperactivation of mTORC1-dependent negative feedback loops leading to the downregulation of insulin signaling and development of insulin resistance. In osteoblasts (OBs), insulin signaling plays a crucial role in the co
Externí odkaz:
https://doaj.org/article/25caf372251e431b8a64b1c2473f1da5
Autor:
Pawanrat Tangseefa, Sally K. Martin, Agnieszka Arthur, Vasilios Panagopoulos, Amanda J. Page, Gary A. Wittert, Christopher G. Proud, Stephen Fitter, Andrew C.W. Zannettino
Publikováno v:
JBMR Plus, Vol 5, Iss 5, Pp n/a-n/a (2021)
ABSTRACT The mammalian target of rapamycin complex 1 (mTORC1) complex is the major nutrient sensor in mammalian cells that responds to amino acids, energy levels, growth factors, and hormones, such as insulin, to control anabolic and catabolic proces
Externí odkaz:
https://doaj.org/article/508e5481eadc4aedbd5040ad51e6553d
Autor:
Vasilios Panagopoulos, Christopher G. Proud, Agnieszka Arthur, Pawanrat Tangseefa, Gary A. Wittert, Amanda J. Page, Andrew C.W. Zannettino, Stephen Fitter, Sally Martin
Publikováno v:
JBMR Plus
JBMR Plus, Vol 5, Iss 5, Pp n/a-n/a (2021)
JBMR Plus, Vol 5, Iss 5, Pp n/a-n/a (2021)
The mammalian target of rapamycin complex 1 (mTORC1) complex is the major nutrient sensor in mammalian cells that responds to amino acids, energy levels, growth factors, and hormones, such as insulin, to control anabolic and catabolic processes. We h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ca109b5ba4cd4f11af00033b0eb394
https://doi.org/10.1002/jbm4.10486
https://doi.org/10.1002/jbm4.10486
Autor:
Gary A. Wittert, Pawanrat Tangseefa, Peck Yin Chin, James Breen, Christopher G. Proud, Amanda J. Page, Chui Yan Mah, Paul A. Baldock, Stephen Fitter, Sally Martin, Andrew C.W. Zannettino
Publikováno v:
Bone Research, Vol 9, Iss 1, Pp 1-17 (2021)
Bone Research
Bone Research
Overnutrition causes hyperactivation of mTORC1-dependent negative feedback loops leading to the downregulation of insulin signaling and development of insulin resistance. In osteoblasts (OBs), insulin signaling plays a crucial role in the control of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b10dc4ad834e9e47540bac8b3f9363c
https://doi.org/10.1038/s41413-020-00123-z
https://doi.org/10.1038/s41413-020-00123-z
Autor:
Stephen Fitter, Andrew C.W. Zannettino, Sally Martin, Christopher G. Proud, Pawanrat Tangseefa, Paul A. Baldock
Publikováno v:
Journal of cellular physiology. 233(5)
The skeleton has recently emerged as a critical insulin target tissue that regulates whole body glucose metabolism and male reproductive function. While our understanding of these new regulatory axes remains in its infancy, the bone-specific protein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3f78809590d50863e35e4a1ae17ab3
https://pubmed.ncbi.nlm.nih.gov/28834550
https://pubmed.ncbi.nlm.nih.gov/28834550