Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Pawan K Singal"'
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0179452 (2017)
We previously reported that Vitamin C (Vit C) protects against doxorubicin (Dox)-induced cardiotoxicity by reducing oxidative stress, p38 mitogen-activated kinase (MAPK) and p53 activation and rescuing cell death in isolated adult cardiomyocytes. The
Externí odkaz:
https://doaj.org/article/6f1a5ca208d9417ab47b8c7f01b609c5
Autor:
Sara M. Telles-Langdon, BKin (Hons), MSc, Vibhuti Arya, BSc (Hons), MSc, Paris R. Haasbeek, David Y.C. Cheung, BSc, Cameron R. Eekhoudt, BSc, MSc, Lana Mackic, BSc, Ashley N. Bryson, BSc, MD, Sonu S. Varghese, BSc, MSc, J. Alejandro Austria, James A. Thliveris, PhD, Harold M. Aukema, PhD, Amir Ravandi, MD, PhD, FRCPC, Pawan K. Singal, PhD, DSc, LLD (Hon), Davinder S. Jassal, MD, FACC, FCCS, FRCPC
Publikováno v:
CJC Open, Vol 6, Iss 7, Pp 925-937 (2024)
Background: Although the current combination of surgery, radiation, and chemotherapy is used in the breast-cancer setting, the administration of the anticancer drugs doxorubicin and trastuzumab is associated with an increased risk of developing heart
Externí odkaz:
https://doaj.org/article/7192a5d768c845a6b6b81c6bb6ecc292
Publikováno v:
Vascular Health and Risk Management, Vol Volume 2, Pp 263-276 (2006)
Sudesh Vasdev1, Vicki Gill1, Pawan K Singal21Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, Canada; 2Institute of Cardiovascular Sciences, University of Manitoba, Faculty of
Externí odkaz:
https://doaj.org/article/19045755de1e4a7485aa8da2ac02632f
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75580 (2013)
Thymosin β4 (Tβ4), a small G-actin sequestering peptide, mediates cell proliferation, migration, and angiogenesis. Whether embryonic stem (ES) cells, overexpressing Tβ4, readily differentiate into cardiac myocytes in vitro and in vivo and enhance
Externí odkaz:
https://doaj.org/article/4ca06d3dd11f4eeb837d47036c2bed94
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25009 (2011)
We have already reported that TNF-α increases cardiomyocyte apoptosis and IL-10 treatment prevented these effects of TNF-α. Present study investigates the role of Akt and Jak/Stat pathway in the IL-10 modulation of TNF-α induced cardiomyocyte apop
Externí odkaz:
https://doaj.org/article/19a31e297e51441da65614e1930a964b
Autor:
Tarunveer Singh Ahluwalia, Madhu Khullar, Monica Ahuja, Harbir Singh Kohli, Anil Bhansali, Viswanathan Mohan, Radha Venkatesan, Taranjit Singh Rai, Kamal Sud, Pawan K Singal
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5168 (2009)
BACKGROUND: Inflammatory cytokine genes have been proposed as good candidate genes for conferring susceptibility to diabetic nephropathy. In the present study, we examined the combined effect of multiple alleles of pro inflammatory cytokine genes for
Externí odkaz:
https://doaj.org/article/8b9c824f7ade48488a056f4fd4d83dc8
Autor:
Cameron R. Eekhoudt, Tessa Bortoluzzi, Sonu S. Varghese, David Y. C. Cheung, Simon Christie, Skyler Eastman, Ishika Mittal, J. Alejandro Austria, Harold M. Aukema, Amir Ravandi, James Thliveris, Pawan K. Singal, Davinder S. Jassal
Publikováno v:
Current Oncology, Vol 29, Iss 5, Pp 2941-2953 (2022)
Background: Two anti-cancer agents, doxorubicin (DOX) and trastuzumab (TRZ), are commonly used in the management of breast cancer in women. Despite their efficacy in reducing the morbidity and mortality of individuals with breast cancer, the use of t
Externí odkaz:
https://doaj.org/article/c9e8e996f3834871b877bd545c967462
Autor:
Arun Surendran, Umar Ismail, Negar Atefi, Ashim K. Bagchi, Pawan K. Singal, Ashish Shah, Michel Aliani, Amir Ravandi
Publikováno v:
Metabolites, Vol 13, Iss 1, p 79 (2023)
The ‘no-reflow’ phenomenon (NRP) after primary percutaneous coronary intervention (PCI) is a serious complication among acute ST-segment elevation myocardial infarction (STEMI) patients. Herein, a comprehensive lipidomics approach was used to qua
Externí odkaz:
https://doaj.org/article/5b77f95c22444e2bbf398eed8b64e5dd
Publikováno v:
Biomedicines, Vol 10, Iss 4, p 890 (2022)
The use of doxorubicin (Dox) in cancer patients carries the risk of cardiotoxicity via an increase in oxidative stress, mitochondrial dysfunction, and disturbed endoplasmic reticulum (ER) homeostasis in cardiomyocytes. The present study explores whic
Externí odkaz:
https://doaj.org/article/0ff435f058f5467cb1e9fd3e2f7879d2
Autor:
Gauri Akolkar, Akshi Malik, Ashim K. Bagchi, Dinender K. Singla, Neelam Khaper, Pawan K. Singal
Publikováno v:
Nitric Oxide: From Research to Therapeutics ISBN: 9783031247774
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ddbedb44cf1267d1c2492da9d4f2020
https://doi.org/10.1007/978-3-031-24778-1_7
https://doi.org/10.1007/978-3-031-24778-1_7
