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Akademický článek

Imaged capillary isoelectric focusing method development for charge variants of high DAR ADCs.

Autor: Leng C; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ, 07065, United States. Electronic address: chuan.leng@merck.com., Sun S; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ, 07065, United States., Lin W; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ, 07065, United States., Pavon JA; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ, 07065, United States., Gennaro L; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ, 07065, United States., Gunawan RC; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ, 07065, United States., Bu X; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ, 07065, United States., Yang T; Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd, No. 666 Xinhua Avenue, Chengdu Cross-Strait Science and Technology Industry Development Park, Wenjiang District, Chengdu, Sichuan Province, PR China., Li S; Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd, No. 666 Xinhua Avenue, Chengdu Cross-Strait Science and Technology Industry Development Park, Wenjiang District, Chengdu, Sichuan Province, PR China.

Publikováno v: Analytica chimica acta [Anal Chim Acta] 2024 Nov 01; Vol. 1328, pp. 343176. Date of Electronic Publication: 2024 Aug 28.

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Akademický článek

An Industry Perspective on the use of Forced Degradation Studies to Assess Comparability of Biopharmaceuticals.

Autor: Campbell JM; GlaxoSmithKline Analytical Development, Upper Providence, PA, 19426, United States., Colombo S; LEO Pharma A/S, Industriparken 55, Ballerup, DK, 2750, Denmark., Doyle JL; Regeneron, Quality Control Analytical Sciences, 81 Columbia Tpke, Rensselaer, NY, 12144, United States., Filoti DI; AbbVie Inc., Development Sciences Data & Digital Strategy, 1N. Waukegan Rd., North Chicago, IL, 60064, United States., Hübner G; Boehringer Ingelheim Pharma GmbH & Co KG, Analytical Dev. Biologicals, 88397, Biberach an der Riss, Germany., Magnenat L; Fresenius Kabi SwissBioSim GmbH, Analytical and Pharmaceutical Development, Route de Crassier 23, 1262, Eysins, Switzerland., Nowinski AK; Seagen Inc., Pharmaceutical Sciences, 21823 30th Drive Southeast, Bothell, WA, 98021, United States., Pavon JA; Merck & Co., Inc., Biologics Analytical Research and Development, 2000 Galloping Hill Road, Kenilworth, NJ, 07033, United States., Singh SM; Bristol Myers Squibb, Analytical Development & Attribute Science, 1 Squibb Drive, North Brunswick, New Jersey, 08902, United States., Vo LR; Novo Nordisk A/S, CMC Analytical development, Novo Nordisk Park B7.2.021, 2760, Maaloev, Denmark., Woods JM; Pfizer, Analytical Research and Development, 875 Chesterfield Pkwy W, Chesterfield, MO, 63017, United States., Stokes ESE; BioPhorum Operations Group, The Gridiron Building, 1 Pancras Square, London, N1C 4AG, United Kingdom. Electronic address: elaine.stokes@biophorum.com.

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2024 Mar; Vol. 113 (3), pp. 505-512. Date of Electronic Publication: 2023 Dec 15.

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Akademický článek

Determination of ultra-trace metal-protein interactions in co-formulated monoclonal antibody drug product by SEC-ICP-MS.

Autor: Whitty-Léveillé L; Analytical Research and Development, Merck & Co, Inc, Rahway, New Jersey., VanAernum ZL; Analytical Research and Development, Merck & Co, Inc, Rahway, New Jersey., Pavon JA; Analytical Research and Development, Merck & Co, Inc, Rahway, New Jersey., Murphy C; Analytical Research and Development, Merck & Co, Inc, Rahway, New Jersey., Neal K; Analytical Research and Development, Merck & Co, Inc, Rahway, New Jersey., Forest W; Analytical Research and Development, Merck & Co, Inc, Rahway, New Jersey., Gao X; Analytical Research and Development, Merck & Co, Inc, Rahway, New Jersey., Zhong W; Analytical Research and Development, Merck & Co, Inc, Rahway, New Jersey., Richardson DD; Analytical Research and Development, Merck & Co, Inc, Rahway, New Jersey., Schuessler HA; Analytical Research and Development, Merck & Co, Inc, Rahway, New Jersey.

Publikováno v: MAbs [MAbs] 2023 Jan-Dec; Vol. 15 (1), pp. 2199466.

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Akademický článek

Regional mutations in CHIKV-ECSA genomes and detection of other viruses in the serum of acute febrile patients by a metagenomic approach in Mato Grosso, Central-Western Brazil, 2018.

Autor: Mendes Dos Santos MA; Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, MT, Brazil; Faculdade de Medicina, Universidade do Estado de Mato Grosso, Cáceres, MT, Brazil., Dias LS; Curso de Graduação em Medicina, Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, MT, Brazil., Ramirez Pavon JA; Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, MT, Brazil., Viniski AE; Laboratório Central do Estado de Mato Grosso, Secretaria Estadoual de Saúde, Cuiabá, MT, Brazil., Campos Souza CL; Laboratório Central do Estado de Mato Grosso, Secretaria Estadoual de Saúde, Cuiabá, MT, Brazil., Pepato MA; Laboratório Central do Estado de Mato Grosso, Secretaria Estadoual de Saúde, Cuiabá, MT, Brazil; Hospital Universitário Júlio Muller, Universidade Federal de Mato Grosso, Cuiabá, MT, Brazil., Correa de Azevedo V; Laboratório Central do Estado de Mato Grosso, Secretaria Estadoual de Saúde, Cuiabá, MT, Brazil., Teixeira Nunes MR; Laboratório de Inovação Tecnológica, Instituto Evandro Chagas, Ministério da Saúde, Belém, PA, Brazil., Slhessarenko RD; Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, MT, Brazil. Electronic address: renata.slhessarenko@ufmt.br.

Publikováno v: Virology [Virology] 2022 Nov; Vol. 576, pp. 18-29. Date of Electronic Publication: 2022 Sep 10.

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Akademický článek

Identification and characterization of a residual host cell protein hexosaminidase B associated with N-glycan degradation during the stability study of a therapeutic recombinant monoclonal antibody product.

Autor: Li X; Analytical Research & Development Mass Spectrometry, Merck & Co., Inc., Kenilworth, New Jersey, USA., An Y; Biologics Analytical Research & Development, Merck & Co., Inc., Kenilworth, New Jersey, USA., Liao J; Analytical Research & Development Mass Spectrometry, Merck & Co., Inc., Kenilworth, New Jersey, USA., Xiao L; Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey, USA., Swanson M; Predictive and Clinical Immunogenicity, Merck & Co., Inc., Kenilworth, New Jersey, USA., Martinez-Fonts K; Biologics Analytical Research & Development, Merck & Co., Inc., Kenilworth, New Jersey, USA., Pavon JA; Biologics Analytical Research & Development, Merck & Co., Inc., Kenilworth, New Jersey, USA., Sherer EC; Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey, USA., Jawa V; Predictive and Clinical Immunogenicity, Merck & Co., Inc., Kenilworth, New Jersey, USA., Wang F; Biologics Analytical Research & Development, Merck & Co., Inc., Kenilworth, New Jersey, USA., Gao X; Analytical Research & Development Mass Spectrometry, Merck & Co., Inc., Kenilworth, New Jersey, USA., Letarte S; Analytical Research & Development Mass Spectrometry, Merck & Co., Inc., Kenilworth, New Jersey, USA., Richardson DD; Analytical Research & Development Mass Spectrometry, Merck & Co., Inc., Kenilworth, New Jersey, USA.

Publikováno v: Biotechnology progress [Biotechnol Prog] 2021 May; Vol. 37 (3), pp. e3128. Date of Electronic Publication: 2021 Mar 12.

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Akademický článek

Selective Tryptophan Oxidation of Monoclonal Antibodies: Oxidative Stress and Modeling Prediction.

Autor: Pavon JA; Process Research & Development , Merck & Co., Inc. , 2015 Galloping Hill Road , Kenilworth , New Jersey 07033 , United States., Xiao L; Modeling and Informatics , Merck & Co., Inc. , 2015 Galloping Hill Road , Kenilworth , New Jersey 07033 , United States., Li X; Process Research & Development , Merck & Co., Inc. , 2015 Galloping Hill Road , Kenilworth , New Jersey 07033 , United States., Zhao J; Process Research & Development , Merck & Co., Inc. , 2015 Galloping Hill Road , Kenilworth , New Jersey 07033 , United States., Aldredge D; Process Research & Development , Merck & Co., Inc. , 2015 Galloping Hill Road , Kenilworth , New Jersey 07033 , United States., Dank E; Process Research & Development , Merck & Co., Inc. , 2015 Galloping Hill Road , Kenilworth , New Jersey 07033 , United States., Fridman A; Process Research & Development , Merck & Co., Inc. , 2015 Galloping Hill Road , Kenilworth , New Jersey 07033 , United States., Liu YH; Process Research & Development , Merck & Co., Inc. , 2015 Galloping Hill Road , Kenilworth , New Jersey 07033 , United States.

Publikováno v: Analytical chemistry [Anal Chem] 2019 Feb 05; Vol. 91 (3), pp. 2192-2200. Date of Electronic Publication: 2019 Jan 16.

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Akademický článek

Analysis of monoclonal antibody oxidation by simple mixed mode chromatography.

Autor: Pavon JA; Bioprocess Development, Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Li X; Bioprocess Development, Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Chico S; Bioprocess Development, Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Kishnani U; Bioprocess Development, Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Soundararajan S; Bioprocess Development, Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Cheung J; Bioprocess Development, Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Li H; Bioprocess Development, Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Richardson D; Bioprocess Development, Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Shameem M; Bioprocess Development, Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Yang X; Bioprocess Development, Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ 07033, USA. Electronic address: xiaoyu.yang@merck.com.

Publikováno v: Journal of chromatography. A [J Chromatogr A] 2016 Jan 29; Vol. 1431, pp. 154-165. Date of Electronic Publication: 2016 Jan 13.

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Akademický článek

Kinetic mechanism of phenylalanine hydroxylase: intrinsic binding and rate constants from single-turnover experiments.

Autor: Roberts KM; Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229, USA., Pavon JA, Fitzpatrick PF

Publikováno v: Biochemistry [Biochemistry] 2013 Feb 12; Vol. 52 (6), pp. 1062-73. Date of Electronic Publication: 2013 Jan 29.

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