Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Pavol Zelina"'
Autor:
Lucas Caldi Gomes, Sonja Hänzelmann, Fabian Hausmann, Robin Khatri, Sergio Oller, Mojan Parvaz, Laura Tzeplaeff, Laura Pasetto, Marie Gebelin, Melanie Ebbing, Constantin Holzapfel, Stefano Fabrizio Columbro, Serena Scozzari, Johanna Knöferle, Isabell Cordts, Antonia F. Demleitner, Marcus Deschauer, Claudia Dufke, Marc Sturm, Qihui Zhou, Pavol Zelina, Emma Sudria-Lopez, Tobias B. Haack, Sebastian Streb, Magdalena Kuzma-Kozakiewicz, Dieter Edbauer, R. Jeroen Pasterkamp, Endre Laczko, Hubert Rehrauer, Ralph Schlapbach, Christine Carapito, Valentina Bonetto, Stefan Bonn, Paul Lingor
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) is a debilitating motor neuron disease and lacks effective disease-modifying treatments. This study utilizes a comprehensive multiomic approach to investigate the early and sex-specific molecular mechanism
Externí odkaz:
https://doaj.org/article/a01f4f133f534a40923cc24277e82506
Autor:
Morgane Belle, David Godefroy, Chloé Dominici, Céline Heitz-Marchaland, Pavol Zelina, Farida Hellal, Frank Bradke, Alain Chédotal
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1191-1201 (2014)
Clearing techniques have been developed to transparentize mouse brains, thereby preserving 3D structure, but their complexity has limited their use. Here, we show that immunolabeling of axonal tracts followed by optical clearing with solvents (3DISCO
Externí odkaz:
https://doaj.org/article/79c5b43caa5b408187a1c34a93ac2398
Autor:
Mathias De Decker, Pavol Zelina, Thomas G Moens, Kristel Eggermont, Matthieu Moisse, Jan H. Veldink, Ludo Van Den Bosch, R. Jeroen Pasterkamp, Philip Van Damme
SUMMARYAmyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease that affects 1 in 400 people. Almost 40 genes have been associated with ALS, currently explaining about 15% of the ALS risk. These genes tend to cluster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77cced94e91ff4ab81ee5abbec8a20a2
https://doi.org/10.1101/2022.02.28.482239
https://doi.org/10.1101/2022.02.28.482239
Autor:
Sean W Willemse, Peter Harley, Ruben P A van Eijk, Koen C Demaegd, Pavol Zelina, R Jeroen Pasterkamp, Philip van Damme, Caroline Ingre, Wouter van Rheenen, Jan H Veldink, Matthew C Kiernan, Ammar Al-Chalabi, Leonard H van den Berg, Pietro Fratta, Michael A van Es
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. :jnnp-2022
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited treatment options and an incompletely understood pathophysiology. Although genomewide association studies (GWAS) have advanced our understanding of the disease, the
Autor:
Pavol Zelina, R. Jeroen Pasterkamp
Publikováno v:
Neuron, 102(3), 512. Cell Press
Neuron
Neuron
The rich functional diversity of the nervous system is founded in the specific connectivity of the underlying neural circuitry. Neurons are often preprogrammed to respond to multiple axon guidance signals because they use sequential guideposts along
Autor:
Juan Antonio Moreno-Bravo, Alain Chédotal, Heike Blockus, Pavol Zelina, Sergi Roig Puiggros, Patrick Mehlen, Chloé Dominici
During the development of the central nervous system (CNS), only motor axons project into peripheral nerves. Little is known about the cellular and molecular mechanisms that control the development of a boundary at the CNS surface and prevent CNS neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b644dd98880daff672eb6f92291f3efc
http://hdl.handle.net/10261/289409
http://hdl.handle.net/10261/289409
Publikováno v:
Development (Cambridge, England). 145(2)
During development, precerebellar neurons migrate tangentially from the dorsal hindbrain to the floor plate. Their axons cross it but their cell bodies stop their ventral migration upon reaching the midline. It has previously been shown that Slit che
Publikováno v:
Development.
During development, precerebellar neurons migrate tangentially from the dorsal hindbrain to the floor plate. Their axons cross it but their cell bodies stop their ventral migration upon reaching the midline. It has previously been shown that Slit che
Autor:
François Friocourt, Zhuhao Wu, Nicolas Rama, Heike Blockus, Jörn Schweitzer, Marc Tessier-Lavigne, Pavol Zelina, Yvrick Zagar, Coralie Fouquet, Erhard Hohenester, Alain Chédotal, Amélie Peres, Hugues Roest Crollius
Publikováno v:
Neuron
Neuron, Elsevier, 2014, 84 (6), pp.1258-1272. ⟨10.1016/j.neuron.2014.11.004⟩
Neuron, 2014, 84 (6), pp.1258-1272. ⟨10.1016/j.neuron.2014.11.004⟩
Neuron, Elsevier, 2014, 84 (6), pp.1258-1272. ⟨10.1016/j.neuron.2014.11.004⟩
Neuron, 2014, 84 (6), pp.1258-1272. ⟨10.1016/j.neuron.2014.11.004⟩
International audience; Development of neuronal circuits is controlled by evolutionarily conserved axon guidance molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin-1, which mediates attraction through the DC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065f03db03e5ce497b0291cef24cd144
https://hal.sorbonne-universite.fr/hal-01102724/file/Zelina_Signaling_Switch_of.pdf
https://hal.sorbonne-universite.fr/hal-01102724/file/Zelina_Signaling_Switch_of.pdf
Publikováno v:
Development. 132:3609-3618
We investigated the role of the cell adhesion molecule NrCAM for axonal growth and pathfinding in the developing retina. Analysis of the distribution pattern of NrCAM in chick embryo retina sections and flat-mounts shows its presence during extension