Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Pavlos Chaitidis"'
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 5, Pp 1397-1409 (2013)
Lipoxygenases (LOX) have been implicated in biosynthesis of pro- and anti-inflammatory mediators, and a previous report suggested compromised leukotriene signaling in H. neanderthalensis. To search for corresponding differences in leukotriene biosynt
Externí odkaz:
https://doaj.org/article/99a58b7e352c44dbac91c80c3b687ab4
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 5, Pp 1397-1409 (2013)
Lipoxygenases (LOX) have been implicated in biosynthesis of pro- and anti-inflammatory mediators, and a previous report suggested compromised leukotriene signaling in H. neanderthalensis. To search for corresponding differences in leukotriene biosynt
Autor:
Benjamin H. Maskrey, Hartmut Kühn, Nicholas Topley, Marcela Rosas, Chantal Sophie Colmont, Philip R. Taylor, Pavlos Chaitidis, Simon Arnett Jones, Valerie B. O'Donnell, Vincent Dioszeghy
Publikováno v:
Scopus-Elsevier
The peritoneal macrophage (Mφ) is the site of greatest 12/15-lipoxygenase (12/15-LOX) expression in the mouse; however, its immunoregulatory role in this tissue has not been explored. Herein, we show that 12/15-LOX is expressed by 95% of resident pe
Autor:
Peter B. Anning, Kate Louise Wright, Pavlos Chaitidis, B. Paul Morgan, Valerie B. O'Donnell, Vincent Dioszeghy, Hartmut Kühn, Erin S. Terry, Adrian J. Hobbs, Simon Jones, Barbara Coles, Jason D. Morrow, Awen Gallimore, Jonathan Morton
Publikováno v:
Blood
Whether leukocytes exert an influence on vascular function in vivo is not known. Here, genetic and pharmacologic approaches show that the absence of neutrophils leads to acute blood pressure dysregulation. Following neutrophil depletion, systolic blo
Publikováno v:
Journal of Cardiovascular Pharmacology. 50:609-620
Vascular remodeling refers to lasting structural alterations in the vessel wall that are initiated in response to external and internal stimuli. These changes are distinct from acute functional responses of blood vessels when challenged by increased
Autor:
Alexandra Bermudez-Fajardo, Pavlos Chaitidis, Valerie B. O'Donnell, Ralf J. Kuban, Ute Ungethuem, Hartmut Kühn
Publikováno v:
Cytokine. 30:366-377
The TH2-cytokines interleukins-4 and -13 severely alter gene expression of monocytic cells. We quantified the impact of interleukins-4 and -13 on the gene expression pattern of human peripheral blood monocytes applying a strategy that involved microa
Autor:
Hartmut Kühn, Pavlos Chaitidis, Jutta Belkner, Christa Gerth, Tanihiro Yoshimoto, Ralf J. Kuban, Hannelore Stender
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 25:797-802
Objectives— Lipoxygenases with different positional specificity have been implicated in atherogenesis, but the precise roles of the various isoforms remain unclear. Because of its capability of oxidizing low-density lipoprotein (LDL) to an atheroge
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 23:1768-1774
Objective— Vasorelaxation of rabbit aorta is mediated by factors released from the vascular endothelium. In the aortic endothelium, arachidonic acid (AA) is metabolized via the 15-lipoxygenase pathway to the vasodilatory compounds 11,12,15-trihydro
Publikováno v:
Journal of Biological Chemistry. 276:42753-42760
Interleukin-4 (IL-4) induces expression of reticulocyte-type 15-lipoxygenase-1 (15-LOX-1) in various mammalian cells via the Janus kinase/signal transducer and activator of transcription 6 (STAT6) signaling system. We studied the mechanism of 15-LOX-
Publikováno v:
Medical science monitor : international medical journal of experimental and clinical research. 11(8)
Th2-cytokines, such as interleukins-4 and -13 (IL-4, IL-13), have been identified as alternative stimuli of monocytes/macrophages. We have recently profiled the gene-expression pattern of IL-4-treated human peripheral monocytes and found that 15-lipo