Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Pavlos C. Englezou"'
Autor:
Gillian Dao Nyesiga, Lieneke Pool, Pavlos C. Englezou, Terese Hylander, Lars Ohlsson, Daniel Appelgren, Anette Sundstedt, Kristina Tillerkvist, Hanne R. Romedahl, Maria Wigren
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Dendritic cells (DCs) are mediators between innate and adaptive immunity and vital in initiating and modulating antigen-specific immune responses. The most important site for induction of tolerance is the gut mucosa, where TGF-β, retinoic acid, and
Externí odkaz:
https://doaj.org/article/f2c2984fc5da4eb8b7fc390b4c372a1e
Autor:
Pavlos C. Englezou, Cedric Sapet, Thomas Démoulins, Panagiota Milona, Thomas Ebensen, Kai Schulze, Carlos-Alberto Guzman, Florent Poulhes, Olivier Zelphati, Nicolas Ruggli, Kenneth C. McCullough
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 118-134 (2018)
Advances in RNA technology during the past two decades have led to the construction of replication-competent RNA, termed replicons, RepRNA, or self-amplifying mRNA, with high potential for vaccine applications. Cytosolic delivery is essential for the
Externí odkaz:
https://doaj.org/article/6f7699c1f6694c1ea0cc9285fd01322f
Autor:
Kenneth C. McCullough, Nicolas Ruggli, Thomas Ebensen, Carlos Guzmán, Maria Pelliccia, Pavlos C. Englezou, Kai Schulze, Thomas Démoulins
Publikováno v:
Journal of Controlled Release. 266:256-271
The major limitations with large and complex self-amplifying RNA vaccines (RepRNA) are RNase-sensitivity and inefficient translation in dendritic cells (DCs). Condensing RepRNA with polyethylenimine (PEI) gave positive in vitro readouts, but was larg
Autor:
Panagiota Milona, Florent Poulhes, Pavlos C. Englezou, Kai Schulze, Olivier Zelphati, Thomas Démoulins, Thomas Ebensen, Cédric Sapet, Kenneth C. McCullough, Nicolas Ruggli, Carlos-Alberto Guzman
Publikováno v:
Molecular Therapy-Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 12, Iss, Pp 118-134 (2018)
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 12, Iss, Pp 118-134 (2018)
Molecular Therapy. Nucleic Acids
Advances in RNA technology during the past two decades have led to the construction of replication-competent RNA, termed replicons, RepRNA, or self-amplifying mRNA, with high potential for vaccine applications. Cytosolic delivery is essential for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a80cf18a8e180baaebc12d8f47a81a0
https://hdl.handle.net/10033/621415
https://hdl.handle.net/10033/621415
Autor:
Pavlos C. Englezou, Thomas Démoulins, Kenneth C. McCullough, Nicolas Ruggli, Lisa Thomann-Harwood, Panagiota Milona, Rolf Suter
Publikováno v:
Vaccines
Vaccines, Vol 2, Iss 4, Pp 735-754 (2014)
McCullough, Kenneth C.; Milona, Panagiota; Thomann-Harwood, Lisa; Demoulins, Thomas; Englezou, Pavlos; Suter, Rolf; Ruggli, Nicolas (2014). Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles. Vaccines, 2(4), pp. 735-754. MDPI 10.3390/vaccines2040735
Vaccines, Vol 2, Iss 4, Pp 735-754 (2014)
McCullough, Kenneth C.; Milona, Panagiota; Thomann-Harwood, Lisa; Demoulins, Thomas; Englezou, Pavlos; Suter, Rolf; Ruggli, Nicolas (2014). Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles. Vaccines, 2(4), pp. 735-754. MDPI 10.3390/vaccines2040735
Dendritic cells (DC) play essential roles determining efficacy of vaccine delivery with respect to immune defence development and regulation. This renders DCs important targets for vaccine delivery, particularly RNA vaccines. While delivery of interf
Autor:
Thomas Ebensen, Thomas Démoulins, Carlos Guzmán, Panagiota Milona, Chantal Pichon, Kenneth C. McCullough, Nicolas Ruggli, Cédric Sapet, Nicola Tirelli, Pavlos C. Englezou
Publikováno v:
RNA Vaccines ISBN: 9781493964796
Most current vaccines are either inactivated pathogen-derived or protein/peptide-based, although attenuated and vector vaccines have also been developed. The former induce at best moderate protection, even as multimeric antigen, due to limitations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22ec84f7a20cb5e7ad4f0644f2afa1d4
https://doi.org/10.1007/978-1-4939-6481-9_3
https://doi.org/10.1007/978-1-4939-6481-9_3
Autor:
Patrick Midoux, Rolf Suter, Kenneth C. McCullough, Panagiota Milona, Nicolas Ruggli, Kai Schulze, Thomas Démoulins, Carlos Guzmán, Chantal Pichon, Thomas Ebensen, Pavlos C. Englezou
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine
Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier, 2016, 12 (3), pp.711-722. ⟨10.1016/j.nano.2015.11.001⟩
Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier, 2016, 12 (3), pp.711-722. ⟨10.1016/j.nano.2015.11.001⟩
International audience; Self-amplifying replicon RNA (RepRNA) are large molecules (12-14kb); their self-replication amplifies mRNA template numbers, affording several rounds of antigen production, effectively increasing vaccine antigen payloads. Thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cefb2698a8b85b053e2a5538ec8b15
https://hal.archives-ouvertes.fr/hal-01406947
https://hal.archives-ouvertes.fr/hal-01406947
Autor:
Pavlos C, Englezou, Simon W, Rothwell, Joseph S, Ainscough, David, Brough, Robert, Landsiedel, Alexei, Verkhratsky, Ian, Kimber, Rebecca J, Dearman
Publikováno v:
Cytokine
Highlights • P2X7R-driven IL-1 responses are markedly enhanced in BMDC compared to BMM. • P2X7R antagonist A-740003 inhibitedIL-1 release in BMDC and BMM. • P2X7R-induced pore formation was greater in BMDC than in BMM. • LPS-primed BMDC resis
Autor:
Kenneth C. McCullough, Pavlos C. Englezou, Panagiota Milona, Nicolas Ruggli, Thomas Démoulins
Publikováno v:
Journal of Blood & Lymph.
Vaccination is the cornerstone for controlling many pathogen infections [1-8], and is also under scrutiny for cancer Immunoprophylaxis/immunotherapy [9,10]. Induction of both antibody and cell-mediated immune (CMI) defences is preferable for ensuring
Publikováno v:
Experimental brain research. 221(4)
Peripheral nerve injuries (PNI) are continuing to be an ever-growing socio-economic burden affecting mainly the young working population and the current clinical treatments to PNI provide a poor clinical outcome involving significant loss of sensatio