Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Pavlos Alifragis"'
Autor:
Jade Marsh, Pavlos Alifragis
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 4, Pp 616-623 (2018)
The most prevalent form of dementia in the elderly is Alzheimer's disease. A significant contributing factor to the progression of the disease appears to be the progressive accumulation of amyloid-β42 (Aβ42), a small hydrophobic peptide. Unfortunat
Externí odkaz:
https://doaj.org/article/ffda3e0b56b748018946a500f3afda98
Publikováno v:
Neurobiology of Disease, Vol 106, Iss , Pp 63-75 (2017)
Alzheimer's disease is the most prevalent form of dementia in the elderly but the precise causal mechanisms are still not fully understood. Growing evidence supports a significant role for Aβ42 oligomers in the development and progression of Alzheim
Externí odkaz:
https://doaj.org/article/00763ccb102541e8a52a93771125d2e4
Autor:
Claire L Russell, Sophia Semerdjieva, Ruth M Empson, Brian M Austen, Philip W Beesley, Pavlos Alifragis
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43201 (2012)
It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer's disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42). However, the unde
Externí odkaz:
https://doaj.org/article/4125f04b5b7b43bbb03e4f158d5b869d
Autor:
Antigoni Ekonomou, Ilias Kazanis, Stavros Malas, Heather Wood, Pavlos Alifragis, Myrto Denaxa, Domna Karagogeos, Andrew Constanti, Robin Lovell-Badge, Vasso Episkopou
Publikováno v:
PLoS Biology, Vol 3, Iss 6, p e186 (2005)
Little is known about the molecular mechanisms and intrinsic factors that are responsible for the emergence of neuronal subtype identity. Several transcription factors that are expressed mainly in precursors of the ventral telencephalon have been sho
Externí odkaz:
https://doaj.org/article/259d5329f4d94323a0ff12654cc77e86
Publikováno v:
Neurobiology of Disease, Vol 106, Iss, Pp 63-75 (2017)
Alzheimer's disease is the most prevalent form of dementia in the elderly but the precise causal mechanisms are still not fully understood. Growing evidence supports a significant role for Aβ42 oligomers in the development and progression of Alzheim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c18725cb5ecd98328f9341ffe89391
http://www.sciencedirect.com/science/article/pii/S0969996117301377
http://www.sciencedirect.com/science/article/pii/S0969996117301377
Autor:
Richard I. Tuxworth, Ane Martin Anduaga, Alaa Hussien-Ali, Matthew J. Taylor, Adam M. Thompson, Sotiroula Chatzimatthaiou, Pavlos Alifragis, Boris Kysela, Charalambos P. Kyriacou, Joanne Longland, Sharif Almutiri, Zubair Ahmed
Publikováno v:
Brain Communications
DNA double strand breaks feature in neurological disorders, including many forms of neurodegeneration, stroke and acute neurotrauma. Tuxworth et al. show that inhibiting the DNA damage sensing response is neuroprotective, axon regenerative and improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8793ed66e866197b36212fff03d339e7
https://doi.org/10.1093/braincomms/fcz005
https://doi.org/10.1093/braincomms/fcz005
Autor:
Ane Martin Anduaga, Richard I. Tuxworth, Matthew J. Taylor, Sharif Almutiri, Zubair Ahmed, Joanne Longland, Boris Kysela, Charalambos P. Kyriacou, Alaa Hussien-Ali, Pavlos Alifragis, Sotiroula Chatzimatthaiou, Adam M. Thompson
Publikováno v:
Brain Communications
DNA double-strand breaks are a feature of many acute and long-term neurological disorders, including neurodegeneration, following neurotrauma and after stroke. Persistent activation of the DNA damage response in response to double strand breaks contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494691945f17eac4a954807c7415f34f
https://doi.org/10.1101/440636
https://doi.org/10.1101/440636
The deep layers of the mammalian cerebral cortex contain pyramidal neurons that project predominantly to subcortical targets. To understand the mechanisms that determine the identity of deeper layer neurons, a PCR based subtractive hybridisation was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c4ab173b5524de913564f475b7e6b3
https://doi.org/10.1016/s1567-133x(03)00090-5
https://doi.org/10.1016/s1567-133x(03)00090-5
Autor:
Pavlos Alifragis, Alaa Hussien-Ali
Publikováno v:
Biochemical Pharmacology. 139:133-134
It is becoming increasingly apparent that the highly amyloidogenic beta-Amyloid 42 peptide is involved in various mechanisms which are instrumental to Alzheimer’s disease (AD) pathogenesis. Recent reports have shown that such a mechanism is the ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1ce65cb808b11b6f761dcae2c372d7e
https://doi.org/10.1016/j.bcp.2017.06.028
https://doi.org/10.1016/j.bcp.2017.06.028
Autor:
Stephan Junek, Peter Gruss, Victor Tarabykin, Pavlos Alifragis, Olga V. Britanova, Kevin R. Jones
Publikováno v:
Developmental Biology
Projection neurons of the developing cerebral cortex are generated in the cerebral ventricular zone and subsequently move to the developing cortical plate via radial migration. Conversely, most inhibitory interneurons originate in the ganglionic emin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1147205204b81feb5ed14f7eee4c5517
https://doi.org/10.1016/j.ydbio.2006.06.040
https://doi.org/10.1016/j.ydbio.2006.06.040