Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Pavlos, Missios"'
Autor:
Michael Bitzer, Stephan Spahn, Sepideh Babaei, Marius Horger, Stephan Singer, Klaus Schulze-Osthoff, Pavlos Missios, Sergios Gatidis, Dominik Nann, Sven Mattern, Veit Scheble, Konstantin Nikolaou, Sorin Armeanu-Ebinger, Martin Schulze, Christopher Schroeder, Saskia Biskup, Janina Beha, Manfred Claassen, Kristina Ruhm, Antti Poso, Nisar P. Malek
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-7 (2021)
Abstract Intrahepatic cholangiocarcinoma (iCCA) has emerged as a promising candidate for precision medicine, especially in the case of activating FGFR2 gene fusions. In addition to fusions, a considerable fraction of iCCA patients reveals FGFR2 mutat
Externí odkaz:
https://doaj.org/article/e53c22a8e93b49a59453c658ede63a6d
Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
Autor:
Joseph W. Franses, Julia Philipp, Pavlos Missios, Irun Bhan, Ann Liu, Chittampalli Yashaswini, Eric Tai, Huili Zhu, Matteo Ligorio, Benjamin Nicholson, Elizabeth M. Tassoni, Niyati Desai, Anupriya S. Kulkarni, Annamaria Szabolcs, Theodore S. Hong, Andrew S. Liss, Carlos Fernandez-del Castillo, David P. Ryan, Shyamala Maheswaran, Daniel A. Haber, George Q. Daley, David T. Ting
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Metastatic dissemination contributes to the lethality in pancreatic ductal adenocarcinoma (PDAC). Here, the authors perform RNA-sequencing on patient derived circulating tumor cells (CTCs) and identify three major CTC subgroups, and show the therapeu
Externí odkaz:
https://doaj.org/article/8bd6be3bfdd24c5bb956606bf62f9ee0
Autor:
Nisar Malek, Przemyslaw Bozko, Khac Cuong Bui, Mohammad Rahbari, Sven Mattern, Pavlos Missios, Mihály Sulyok, Maria Garcia-Beccaria, Mirian Fernandez, Stephanie Roessler, Benjamin Goeppert, Julian Götze, Tim Scholta, Sebastian Reuter, Thi Mai Ly Nguyen, Mahmoud Toulany, Ying Shi, Mathias Riebold, Ramona Rudalska, Daniel Dauch, Lars Zender, Peter Schirmacher, Daniel Zips, Stephan Singer, Mattias Heikenwaelder
Reduced expression of the cyclin kinase inhibitor p27kip1 is found in many human tumors and correlates with inferior prognosis. We tested the importance of p27 loss for the induction of genetic instability in Notch driven cholangiocarcinoma (CCA). Sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::575e7d99e1d27e0bc6190a29400a0046
https://doi.org/10.21203/rs.3.rs-2889500/v1
https://doi.org/10.21203/rs.3.rs-2889500/v1
Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
Autor:
Carlos Fernandez-del Castillo, Andrew S. Liss, Matteo Ligorio, Eric Tai, Chittampalli Yashaswini, A. W. K. Liu, David P. Ryan, Julia Philipp, Daniel A. Haber, Huili Zhu, Anupriya S. Kulkarni, Pavlos Missios, Elizabeth M. Tassoni, Joseph W. Franses, Theodore S. Hong, Niyati Desai, Annamaria Szabolcs, Irun Bhan, George Q. Daley, David T. Ting, Benjamin Nicholson, Shyamala Maheswaran
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Pancreatic ductal adenocarcinoma (PDAC) lethality is due to metastatic dissemination. Characterization of rare, heterogeneous circulating tumor cells (CTCs) can provide insight into metastasis and guide development of novel therapies. Using the CTC-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395d138f2f8276aee48b2fa8a10ea277
http://link.springer.com/article/10.1038/s41467-020-17150-3
http://link.springer.com/article/10.1038/s41467-020-17150-3
Autor:
Ting Tao, A. Thomas Look, Antonio R. Perez-Atayde, Luca Mariani, George Q. Daley, Mark W. Zimmerman, Brian J. Abraham, Martha L. Bulyk, Pavlos Missios, John T. Powers, Richard A. Young, Kenneth N. Ross, Adam D. Durbin, Hui Shi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance LIN28B is well known as a RNA-binding protein and a suppressor of microRNA biogenesis by selectively blocking the processing of let-7 precursors. However, little is known about let-7–independent roles of LIN28B. Here, we show that LIN2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a36bd89610a48ec649e4c0022ac0b8
https://doi.org/10.1073/pnas.1922692117
https://doi.org/10.1073/pnas.1922692117
Publikováno v:
Der Onkologe. 26:679-684
Nach Einfuhrung neuer Sequenzierungsmethoden ergeben sich neue Moglichkeiten in der Diagnostik maligner Erkrankungen. Dies erfordert allerdings eine Anpassung der klinischen Ablaufe. Die Informationen mussen in den richtigen Kontext gebracht werden,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54e01133782b128a9cc0298a2549c01
https://doi.org/10.1007/s00761-020-00775-w
https://doi.org/10.1007/s00761-020-00775-w
Autor:
Richard I. Gregory, Mehdi Pirouz, Daniel S. Pearson, Pavlos Missios, Amy S. Lee, George Q. Daley, Edroaldo Lummertz da Rocha, David T. Ting, Caroline Kubaczka, Kaloyan M. Tsanov, Joseph W. Franses, Daniel Dominguez, Brian Pepe-Mooney, Dorian Farache, John T. Powers, Deepak Kumar Jha, Julia Philipp, Maria M. Aleman
Publikováno v:
J Clin Invest
High expression of LIN28B is associated with aggressive malignancy and poor survival. Here, probing MYCN-amplified neuroblastoma as a model system, we showed that LIN28B expression was associated with enhanced cell migration in vitro and invasive and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a147bf052b2a9df3483dfea7d1212b52
https://doi.org/10.1172/jci145142
https://doi.org/10.1172/jci145142
Autor:
Pınar Özden, Eser, Raymond M, Paranal, Jieun, Son, Elena, Ivanova, Yanan, Kuang, Heidi M, Haikala, Ciric, To, Jeffrey J, Okoro, Kshiti H, Dholakia, Jihyun, Choi, Yoonji, Eum, Atsuko, Ogino, Pavlos, Missios, Dalia, Ercan, Man, Xu, Michael J, Poitras, Stephen, Wang, Kenneth, Ngo, Michael, Dills, Masahiko, Yanagita, Timothy, Lopez, Mika, Lin, Jeanelle, Tsai, Nicolas, Floch, Emily S, Chambers, Jennifer, Heng, Rana, Anjum, Alison D, Santucci, Kesi, Michael, Alwin G, Schuller, Darren, Cross, Paul D, Smith, Geoffrey R, Oxnard, David A, Barbie, Lynette M, Sholl, Magda, Bahcall, Sangeetha, Palakurthi, Prafulla C, Gokhale, Cloud P, Paweletz, George Q, Daley, Pasi A, Jänne
Publikováno v:
Science translational medicine
The clinical efficacy of epidermal growth factor receptor (EGFR)–targeted therapy in EGFR-mutant non–small cell lung cancer is limited by the development of drug resistance. One mechanism of EGFR inhibitor resistance occurs through amplification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22efb640067814269983395f20ecc3cd
https://pubmed.ncbi.nlm.nih.gov/34516823
https://pubmed.ncbi.nlm.nih.gov/34516823
Autor:
Emily S. Chambers, Alwin Schuller, Stephen Wang, Dalia Ercan, Mika Lin, Pınar Özden Eser, Raymond M. Paranal, Nicolas Floc'h, Sangeetha Palakurthi, Alison D. Santucci, Jeffrey J. Okoro, Geoffrey R. Oxnard, Man Xu, Kenneth H. Ngo, Jeanelle Tsai, Ciric To, Lynette M. Sholl, George Q. Daley, Michael Dills, Pavlos Missios, Kesi Michael, Paul D. Smith, Yoonji Eum, Magda Bahcall, Yanan Kuang, David A. Barbie, Masahiko Yanagita, Jennifer C. Heng, Rana Anjum, Prafulla C. Gokhale, Elena Ivanova, Jieun Son, Kshiti Dholakia, Heidi M. Haikala, Darren Cross, Jihyun Choi, Michael J. Poitras, Pasi A. Jänne, Timothy Lopez, Cloud P. Paweletz, Atsuko Ogino
Publikováno v:
Science Translational Medicine. 13
A subset of drug-resistant EGFR -mutant MET -amplified lung cancer switches oncogenic dependence to MET and is treatable with MET inhibitor monotherapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f7c7b3de9b86168add52ec03c24e84e
https://doi.org/10.1126/scitranslmed.abb3738
https://doi.org/10.1126/scitranslmed.abb3738
Publikováno v:
Der Chirurg; Zeitschrift fur alle Gebiete der operativen MedizenLiteratur. 92(11)
New diagnostic tools in the field of oncology that became available with introduction of the next generation sequencing call for adjustments in the current clinical workflow. To ensure correct interpretation, newly collected data need to be processed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::965e86a0e886c199542b52503ef006ac
https://pubmed.ncbi.nlm.nih.gov/34406439
https://pubmed.ncbi.nlm.nih.gov/34406439