Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Pavlo Gilchuk"'
Autor:
Philipp A. Ilinykh, Kai Huang, Bronwyn M. Gunn, Natalia A. Kuzmina, Kritika Kedarinath, Eduardo Jurado-Cobena, Fuchun Zhou, Chandru Subramani, Matthew A. Hyde, Jalene V. Velazquez, Lauren E. Williamson, Pavlo Gilchuk, Robert H. Carnahan, Galit Alter, James E. Crowe, Alexander Bukreyev
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Antibodies to Ebola virus glycoprotein (EBOV GP) represent an important correlate of the vaccine efficiency and infection survival. Both neutralization and some of the Fc-mediated effects are known to contribute the protection conferred by a
Externí odkaz:
https://doaj.org/article/446ca9702148453eb38e081a5253376d
Autor:
Philipp A. Ilinykh, Kai Huang, Bronwyn M. Gunn, Natalia A. Kuzmina, Kritika Kedarinath, Eduardo Jurado-Cobena, Fuchun Zhou, Chandru Subramani, Matthew A. Hyde, Jalene V. Velazquez, Lauren E. Williamson, Pavlo Gilchuk, Robert H. Carnahan, Galit Alter, James E. Crowe, Alexander Bukreyev
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/363dea2b3f8140e3a227009c6ff258aa
Autor:
Elaine C. Chen, Pavlo Gilchuk, Seth J. Zost, Philipp A. Ilinykh, Elad Binshtein, Kai Huang, Luke Myers, Stefano Bonissone, Samuel Day, Chandrahaas R. Kona, Andrew Trivette, Joseph X. Reidy, Rachel E. Sutton, Christopher Gainza, Summer Diaz, Jazmean K. Williams, Christopher N. Selverian, Edgar Davidson, Erica Ollmann Saphire, Benjamin J. Doranz, Natalie Castellana, Alexander Bukreyev, Robert H. Carnahan, James E. Crowe, Jr.
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112370- (2023)
Summary: Understanding the human antibody response to emerging viral pathogens is key to epidemic preparedness. As the size of the B cell response to a pathogenic-virus-protective antigen is poorly defined, we perform deep paired heavy- and light-cha
Externí odkaz:
https://doaj.org/article/bf9215d14449450b85f7bee1f2faf9da
Autor:
Naveenchandra Suryadevara, Pavlo Gilchuk, Seth J. Zost, Nikhil Mittal, Li Leyna Zhao, James E. Crowe, Jr., Robert H. Carnahan
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101387- (2022)
Summary: Real-time cell analysis (RTCA) enables high-throughput, quantitative kinetic measurements of cytopathic effect (CPE) in virus-infected cells. Here, we detail a RTCA approach for assessing antibody neutralization. We describe how to evaluate
Externí odkaz:
https://doaj.org/article/90940ceb7c1b41758764c2addcec7f6b
Autor:
Clara T Schoeder, Pavlo Gilchuk, Amandeep K Sangha, Kaitlyn V Ledwitch, Delphine C Malherbe, Xuan Zhang, Elad Binshtein, Lauren E Williamson, Cristina E Martina, Jinhui Dong, Erica Armstrong, Rachel Sutton, Rachel Nargi, Jessica Rodriguez, Natalia Kuzmina, Brooke Fiala, Neil P King, Alexander Bukreyev, James E Crowe, Jens Meiler
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010518 (2022)
The three human pathogenic ebolaviruses: Zaire (EBOV), Bundibugyo (BDBV), and Sudan (SUDV) virus, cause severe disease with high fatality rates. Epitopes of ebolavirus glycoprotein (GP) recognized by antibodies with binding breadth for all three ebol
Externí odkaz:
https://doaj.org/article/83108648321c484bbf22f4df7b598b39
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Monoclonal antibodies (mAbs) have proven effective for the treatment of ebolavirus infection in humans, with two mAb-based drugs Inmazeb™ and Ebanga™ receiving FDA approval in 2020. While these drugs represent a major advance in the field of filo
Externí odkaz:
https://doaj.org/article/3d8221729b754c6a80c2933ef7702fe8
Autor:
Pavlo Gilchuk, Isaac Thomsen, Sandra Yoder, Eric Brady, James D. Chappell, Laura J. Stevens, Mark R. Denison, Rachel E. Sutton, Rita E. Chen, Laura A. VanBlargan, Naveenchandra Suryadevara, Seth J. Zost, Jonathan Schmitz, Jill M. Pulley, Michael S. Diamond, Jillian P. Rhoads, Gordon R. Bernard, Wesley H. Self, Todd W. Rice, Allison P. Wheeler, James E. Crowe, Jr., Robert H. Carnahan
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103602- (2022)
Summary: The COVID-19 pandemic revealed an urgent need for rapid profiling of neutralizing antibody responses and development of antibody therapeutics. The current Food and Drug Administration-approved serological tests do not measure antibody-mediat
Externí odkaz:
https://doaj.org/article/50ddb15ad4ec4f03a1aedb2f937e5006
Autor:
Elaine C. Chen, Pavlo Gilchuk, Seth J. Zost, Naveenchandra Suryadevara, Emma S. Winkler, Carly R. Cabel, Elad Binshtein, Rita E. Chen, Rachel E. Sutton, Jessica Rodriguez, Samuel Day, Luke Myers, Andrew Trivette, Jazmean K. Williams, Edgar Davidson, Shuaizhi Li, Benjamin J. Doranz, Samuel K. Campos, Robert H. Carnahan, Curtis A. Thorne, Michael S. Diamond, James E. Crowe, Jr.
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109604- (2021)
Summary: Unrelated individuals can produce genetically similar clones of antibodies, known as public clonotypes, which have been seen in responses to different infectious diseases, as well as healthy individuals. Here we identify 37 public clonotypes
Externí odkaz:
https://doaj.org/article/b641b5a3e5504c6aba50fe6b796af664
Autor:
Maritza Puray-Chavez, Kyle M. LaPak, Travis P. Schrank, Jennifer L. Elliott, Dhaval P. Bhatt, Megan J. Agajanian, Ria Jasuja, Dana Q. Lawson, Keanu Davis, Paul W. Rothlauf, Zhuoming Liu, Heejoon Jo, Nakyung Lee, Kasyap Tenneti, Jenna E. Eschbach, Christian Shema Mugisha, Emily M. Cousins, Erica W. Cloer, Hung R. Vuong, Laura A. VanBlargan, Adam L. Bailey, Pavlo Gilchuk, James E. Crowe, Jr., Michael S. Diamond, D. Neil Hayes, Sean P.J. Whelan, Amjad Horani, Steven L. Brody, Dennis Goldfarb, M. Ben Major, Sebla B. Kutluay
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109364- (2021)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) variants govern transmissibility, responsiveness to vaccination, and disease severity. In a screen for new models of SARS-CoV-2 infection, we identify human H522 lung ade
Externí odkaz:
https://doaj.org/article/fd7ca3003b0d4b6e81dd2ed8d532da99
Autor:
Pavlo Gilchuk, Adrian Guthals, Stefano R. Bonissone, Jared B. Shaw, Philipp A. Ilinykh, Kai Huang, Robin G. Bombardi, Jenny Liang, Ariadna Grinyo, Edgar Davidson, Elaine C. Chen, Bronwyn M. Gunn, Galit Alter, Erica Ollmann Saphire, Benjamin J. Doranz, Alexander Bukreyev, Larry Zeitlin, Natalie Castellana, James E. Crowe
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Three clinically relevant ebolaviruses – Ebola (EBOV), Bundibugyo (BDBV), and Sudan (SUDV) viruses, are responsible for severe disease and occasional deadly outbreaks in Africa. The largest Ebola virus disease (EVD) epidemic to date in 2013-2016 in
Externí odkaz:
https://doaj.org/article/2ef1a2038a8f41a282739eef084ecc77