Výsledky vyhledávání - "Pavlo A Nesterenko"

Akademický článek

Latent CMV infection of Lymphatic endothelial cells is sufficient to drive CD8 T cell memory inflation.

Autor: Michael W Munks, Katherine Rott, Pavlo A Nesterenko, Savannah M Smart, Venasha Williams, Angela Tatum, Guangwu Xu, Tameka Smith, Susan E Murray, Ann B Hill

Publikováno v: PLoS Pathogens, Vol 19, Iss 1, p e1010351 (2023)

CMV, a ubiquitous herpesvirus, elicits an extraordinarily large T cell response that is sustained or increases over time, a phenomenon termed 'memory inflation.' Remarkably, even latent, non-productive infection can drive memory inflation. Despite in

Externí odkaz: https://doaj.org/article/95e2f51f80464c72a12f15090ab3ddc7

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IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 21

Alternative splicing (AS) is prevalent in cancer, generating an extensive but largely unexplored repertoire of novel immunotherapy targets. We describe I soform peptides from R NA splicing for I mmunotherapy target S creening (IRIS), a computational

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93609197fd5c544787a244456cbfc71
https://doi.org/10.1073/pnas.2221116120

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Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 31

Tissue-specific antigens can serve as targets for adoptive T cell transfer-based cancer immunotherapy. Recognition of tumor by T cells is mediated by interaction between peptide–major histocompatibility complexes (pMHCs) and T cell receptors (TCRs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39afba213dbd49e1152b82e74057d229
https://escholarship.org/uc/item/7k4312v2

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CD8 T Cell Memory Inflation is Driven by Latent CMV Infection of Lymphatic Endothelial Cells

Autor: Michael W. Munks, Katherine Rott, Pavlo A. Nesterenko, Savannah M. Smart, Venasha Williams, Angela Tatum, George Xu, Tameka Smith, Susan E. Murray, Ann B. Hill

CMV, a ubiquitous herpesvirus, elicits an extraordinarily large T cell response that is sustained or increases over time, a phenomenon termed ‘memory inflation.’ Remarkably, even latent, non-productive infection can drive memory inflation. Despit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e221f51f28fa806aae239bd84cf4465d
https://doi.org/10.1101/2022.02.10.479848

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HLA-A∗02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses

Publikováno v: Cell Reports

Cross-reactivity and direct killing of target cells remain underexplored for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific CD8+ T cells. Isolation of T cell receptors (TCRs) and overexpression in allogeneic cells allows for ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab3372958a954daff44b4d324559063
https://resolver.caltech.edu/CaltechAUTHORS:20211210-240628000

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Droplet-based mRNA sequencing of fixed and permeabilized cells by CLInt-seq allows for antigen-specific TCR cloning

Autor: Zhiyuan Mao, John W. Phillips, Matthew B. Obusan, Donghui Cheng, Jami McLaughlin, Pavlo A Nesterenko, Nathanael J Bangayan, Christopher S. Seet, Yu Qin, Owen N. Witte, Giselle Burton Sojo

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 3

T cell receptors (TCRs) are generated by somatic recombination of V/D/J segments to produce up to 1015 unique sequences. Highly sensitive and specific techniques are required to isolate and identify the rare TCR sequences that respond to antigens of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa4ba881e51ec0d3337556a0eec4b1a
https://escholarship.org/uc/item/1w24552c

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A Phase 1 Study of 4 Live, Recombinant Human Cytomegalovirus Towne/Toledo Chimera Vaccines in Cytomegalovirus–Seronegative Men

Autor: Ann B. Hill, George Kemble, Michael A. McVoy, Pavlo A. Nesterenko, Stanley A. Plotkin, Anne Marie Manganello, Josephine H. Cox, Ronzo Lee, Daniel E. Nixon, Edward S. Mocarski, Stuart P. Adler, Patricia E. Fast, Susan E. Murray

Publikováno v: Journal of Infectious Diseases. 214:1341-1348

Background Human cytomegalovirus (HCMV) infection causes disease in newborns and transplant recipients. A HCMV vaccine (Towne) protects transplant recipients. Methods The genomes of Towne and the nonattenuated Toledo strain were recombined, yielding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1c3f645e270c7a9e5b6cac4b004808
https://doi.org/10.1093/infdis/jiw365

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Fibroblast-adapted human CMV vaccines elicit predominantly conventional CD8 T cell responses in humans

Autor: Ronzo Lee, Ilias I.N. Doxiadis, Eren M. Veziroglu, Frans H.J. Claas, Susan E. Murray, Adam L. Vanarsdall, Lavinia C. Sagario, Michael W. Munks, Savannah Smart, Ann B. Hill, Michael A. McVoy, Pavlo A. Nesterenko, Stuart P. Adler

Publikováno v: Journal of Experimental Medicine, 214(7), 1889-1899
The Journal of Experimental Medicine

Fibroblast-adapted rhesus CMV–vectored vaccines protect macaques from SIV challenge and elicit unconventional CD8 T cell responses. In contrast, Murray et al. show that humans vaccinated with fibroblast-adapted human CMV vaccines generate conventio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7403814b030e7c0225501043a20e9371
https://hdl.handle.net/1887/115934

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