Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Pavlina, Baevova"'
Autor:
Katherine L. Leiby, Yifan Yuan, Ronald Ng, Micha Sam Brickman Raredon, Taylor S. Adams, Pavlina Baevova, Allison M. Greaney, Karen K. Hirschi, Stuart G. Campbell, Naftali Kaminski, Erica L. Herzog, Laura E. Niklason
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-18 (2023)
Abstract Engineered whole lungs may one day expand therapeutic options for patients with end-stage lung disease. However, the feasibility of ex vivo lung regeneration remains limited by the inability to recapitulate mature, functional alveolar epithe
Externí odkaz:
https://doaj.org/article/343c803588cf4335a13da17cd8eca48c
Autor:
Yifan Yuan, Katherine L. Leiby, Allison M. Greaney, Micha Sam Brickman Raredon, Hong Qian, Jonas C. Schupp, Alexander J. Engler, Pavlina Baevova, Taylor S. Adams, Mehmet H. Kural, Juan Wang, Tomohiro Obata, Mervin C. Yoder, Naftali Kaminski, Laura E. Niklason
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
The development of an in vitro system for the study of lung vascular disease is critical to understanding human pathologies. Conventional culture systems fail to fully recapitulate native microenvironmental conditions and are typically limited in the
Externí odkaz:
https://doaj.org/article/27fd7b2723344f87ac6ed4658c43120a
Autor:
Micha Sam Brickman, Raredon, Clark, Fisher, Paul M, Heerdt, Robert B, Schonberger, Alyssa, Nargi, Steven, Nivison, Elaine, Fajardo, Ranjit, Deshpande, Shamsuddin, Akhtar, Allison M, Greaney, Joseph, Belter, Thomas, Raredon, Joseph, Zinter, Andrew, McKee, Mark, Michalski, Pavlina, Baevova, Laura E, Niklason
Publikováno v:
Anesthesia & Analgesia. 134:1094-1105
The coronavirus disease 2019 (COVID-19) pandemic has revealed that even the best-resourced hospitals may lack sufficient ventilators to support patients under surge conditions. During a pandemic or mass trauma, an affordable, low-maintenance, off-the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3086876e93976dcd39f65e8c643ccc0d
https://doi.org/10.1213/ane.0000000000005825
https://doi.org/10.1213/ane.0000000000005825
Autor:
Katherine L. Leiby, Yifan Yuan, Ronald Ng, Micha Sam Brickman Raredon, Taylor S. Adams, Pavlina Baevova, Karen K. Hirschi, Stuart G. Campbell, Naftali Kaminski, Erica L. Herzog, Laura E. Niklason
Therapeutic lung regeneration is predicated upon successful reconstitution of lung alveoli, the functional units of gas exchange. Here, we identify requisite multimodal cues that are critical to reconstructing the alveolar epithelium and alveoli in l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a36405a6c719a91a8e078c387e645274
https://doi.org/10.1101/2022.03.13.484143
https://doi.org/10.1101/2022.03.13.484143
Autor:
Laura E. Niklason, Mervin C. Yoder, Alexander J. Engler, Yifan Yuan, Micha Sam Brickman Raredon, Andrew V. Le, Pavlina Baevova
Publikováno v:
Biomaterials. 200:25-34
Whole organ engineering paradigms typically involve repopulating acellular organ scaffolds with recipient-compatible cells, to generate a neo-organ that may provide key physiological functions. In the case of whole lung engineering, functionally endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ce75aafcbf3c0d5545e7c52d093ae1
https://doi.org/10.1016/j.biomaterials.2019.02.005
https://doi.org/10.1016/j.biomaterials.2019.02.005
Autor:
Alexander J. Engler, Elizabeth A. Calle, Mahboobe Ghaedi, Laura E. Niklason, Pavlina Baevova, Arkadi Beloiartsev, Andrew V. Le, Go Hatachi
Publikováno v:
ACS biomaterials scienceengineering. 3(9)
To date, efforts to generate engineered lung tissue capable of long-term function have been limited by incomplete barrier formation between air and blood and by thrombosis of the microvasculature upon exposure of blood to the collagens within the dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3b7bc4b5a3ebf028a258c6202594bf
https://pubmed.ncbi.nlm.nih.gov/33440555
https://pubmed.ncbi.nlm.nih.gov/33440555
Autor:
Katherine L. Leiby, Laura E. Niklason, Young Hong, Jonas C. Schupp, Pavlina Baevova, Mehmet H. Kural, Taylor S Admas, Yifan Yuan, Naftali Kaminski, Allison M. Greaney, Micha Sam Brickman Raredon, Alexander J. Engler, Hong Qian
Publikováno v:
Circulation. 142
Introduction: The development of an in vitro system is critical to studying human diseases including the novel coronavirus disease-19 (COVID-19), and is typically centered on recapitulating native physiology. In the case of the pulmonary vasculature,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecba9e85bf758845dcef92e6b26f9b6d
https://doi.org/10.1161/circ.142.suppl_3.14125
https://doi.org/10.1161/circ.142.suppl_3.14125
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 12:e119-e129
In cellular, tissue-level or whole organ bioreactors, the level of dissolved oxygen is one of the most important factors requiring control. Hypoxic environments may lead to cellular apoptosis, while hyperoxic environments may lead to cellular damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d72aef206f5ffcd50d958d62d0ac6668
https://doi.org/10.1002/term.2408
https://doi.org/10.1002/term.2408
Autor:
Yifan Yuan, Ellen L. Kan, Andrew V. Le, Pavlina Baevova, Alexander J. Engler, Yan A. Oczkowicz, Micha Sam Brickman Raredon, Laura E. Niklason
Publikováno v:
Biomaterials
Microvascular leak is a phenomenon witnessed in multiple disease states. In organ engineering, regaining a functional barrier is the most crucial step towards creating an implantable organ. All previous methods of measuring microvascular permeability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17e319337a1205830b69ad92dfd7e5e
https://pubmed.ncbi.nlm.nih.gov/31280072
https://pubmed.ncbi.nlm.nih.gov/31280072
Autor:
Ashley L. Gard, Elise C. Wilcox, Rachel Dyal, Jonas Schwan, Eric S. White, Pavlina Baevova, Angela Liu, Huanxing Sun, Sashka Dimitrievska, Martin A. Schwartz, Laure Rittié, Laura E. Niklason, Andrew V. Le, Kristin A. Gerhold, Thomas J. Broekelmann, Sumati Sundaram, Liping Zhao, Robert P. Mecham, Jenna L. Balestrini
Publikováno v:
Biomaterials. 102:220-230
Lung engineering is a promising technology, relying on re-seeding of either human or xenographic decellularized matrices with patient-derived pulmonary cells. Little is known about the species-specificity of decellularization in various models of lun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e289839036e879263f48542e5ccb0538
https://doi.org/10.1016/j.biomaterials.2016.06.025
https://doi.org/10.1016/j.biomaterials.2016.06.025