Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Pavle Vrljicak"'
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113525- (2023)
Summary: Estrogen-dependent proliferation followed by progesterone-dependent differentiation of the endometrium culminates in a short implantation window. We performed single-cell assay for transposase-accessible chromatin with sequencing on endometr
Externí odkaz:
https://doaj.org/article/04b5540ff1224a84ac4f6fe9a82910d7
Autor:
Christopher B. Mahony, Lucy Copper, Pavle Vrljicak, Boris Noyvert, Chrystala Constantinidou, Sofia Browne, Yi Pan, Claire Palles, Sascha Ott, Martin R. Higgs, Rui Monteiro
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112571- (2023)
Summary: Inherited bone marrow failure associated with heterozygous mutations in GATA2 predisposes toward hematological malignancies, but the mechanisms remain poorly understood. Here, we investigate the mechanistic basis of marrow failure in a zebra
Externí odkaz:
https://doaj.org/article/10924ed2ad3f41449b9a5557d42942ee
Autor:
Laura Hume, Jessica C. Edge, Haidee Tinning, Dapeng T. Wang, Alysha S. Taylor, Vladimir Ovchinnikov, Annika V. Geijer-Simpson, Pavle Vrljicak, Jan J. Brosens, Emma S. Lucas, Nigel A.B. Simpson, Jayne Shillito, Karen Forbes, Mary J. O’Connell, Niamh Forde
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106339- (2023)
Summary: We tested the hypothesis that conserved placental mammal-specific microRNAs and their targets facilitate endometrial receptivity to implantation. Expression of miR-340-5p, -542-3p, and -671-5p was regulated by exposure of endometrial epithel
Externí odkaz:
https://doaj.org/article/53288b4ef1ff4e27859d5eecc43cebec
Autor:
Eleni Syrimi, Eanna Fennell, Alex Richter, Pavle Vrljicak, Richard Stark, Sascha Ott, Paul G. Murray, Eslam Al-Abadi, Ashish Chikermane, Pamela Dawson, Scott Hackett, Deepthi Jyothish, Hari Krishnan Kanthimathinathan, Sean Monaghan, Prasad Nagakumar, Barnaby R. Scholefield, Steven Welch, Naeem Khan, Sian Faustini, Kate Davies, Wioleta M. Zelek, Pamela Kearns, Graham S. Taylor
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103215- (2021)
Summary: Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening disease occurring several weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Deep immune profiling showed acute MIS-C patients had h
Externí odkaz:
https://doaj.org/article/cb7ebce799514eb180b30ec967fb855b
Autor:
Raffaella Lucciola, Pavle Vrljicak, Shanti Gurung, Caitlin Filby, Saeedeh Darzi, Joanne Muter, Sascha Ott, Jan J. Brosens, Caroline E. Gargett
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Endometrial mesenchymal stem cells (eMSC) drive the extraordinary regenerative capacity of the human endometrium. Clinical application of eMSC for therapeutic purposes is hampered by spontaneous differentiation and cellular senescence upon large-scal
Externí odkaz:
https://doaj.org/article/ce1d9ed3b6614cc29b04de419dd5d8d6
Autor:
Pavle Vrljicak, Shijie Tao, Gaurav K. Varshney, Helen Ngoc Bao Quach, Adita Joshi, Matthew C. LaFave, Shawn M. Burgess, Karuna Sampath
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 4, Pp 805-817 (2016)
DNA transposons and retroviruses are important transgenic tools for genome engineering. An important consideration affecting the choice of transgenic vector is their insertion site preferences. Previous large-scale analyses of Ds transposon integrati
Externí odkaz:
https://doaj.org/article/5c35cda2ad5a491583d816730d6ff383
Autor:
Paul J Brighton, Yojiro Maruyama, Katherine Fishwick, Pavle Vrljicak, Shreeya Tewary, Risa Fujihara, Joanne Muter, Emma S Lucas, Taihei Yamada, Laura Woods, Raffaella Lucciola, Yie Hou Lee, Satoru Takeda, Sascha Ott, Myriam Hemberger, Siobhan Quenby, Jan Joris Brosens
Publikováno v:
eLife, Vol 6 (2017)
In cycling human endometrium, menstruation is followed by rapid estrogen-dependent growth. Upon ovulation, progesterone and rising cellular cAMP levels activate the transcription factor Forkhead box O1 (FOXO1) in endometrial stromal cells (EnSCs), le
Externí odkaz:
https://doaj.org/article/667854c7f71a4875a2003ebd85d55dec
Autor:
Pavle Vrljicak, Rebecca Cullum, Eric Xu, Alex C Y Chang, Elizabeth D Wederell, Mikhail Bilenky, Steven J M Jones, Marco A Marra, Aly Karsan, Pamela A Hoodless
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40815 (2012)
Malformations of the cardiovascular system are the most common type of birth defect in humans, frequently affecting the formation of valves and septa. During heart valve and septa formation, cells from the atrio-ventricular canal (AVC) and outflow tr
Externí odkaz:
https://doaj.org/article/7250fa1161ad4d2f80e77930d2507243
Autor:
Laura Hume, Jessica C. Edge, Haidee Tinning, Dapeng Wang, Alysha S. Taylor, Vladimir Ovchinnikov, Annika Geijer-Simpson, Pavle Vrljicak, Jan J. Brosens, Emma S. Lucas, Nigel A.B. Simson, Jane Shillito, Karen Forbes, Mary J. O’Connell, Niamh Forde
We tested the hypothesis that a panel of placental mammal-specific miRNAs and their targets play important to establish receptivity to implantation and their dysregulated expression may be a feature in women with early pregnancy loss. Relative expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a655f4b254dd221e3c5afe5320453e46
https://doi.org/10.1101/2022.04.23.489270
https://doi.org/10.1101/2022.04.23.489270
Autor:
Emma S. Lucas, Sascha Ott, Pavle Vrljicak, Jan J. Brosens, Joanne Muter, Katherine J. Fishwick, Komal Makwana, Joshua Odendaal, Julia Lipecki, Andrew E Mitchell, Amelia Hawkes
STUDY QUESTIONCan the accuracy of timing of luteal phase endometrial biopsies based on urinary ovulation testing be improved by measuring the expression of a small number of genes and a continuous, non-categorical modelling approach?SUMMARY ANSWERMea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e28ead71ee6fa9d9029955b22d91681f
https://doi.org/10.1101/2021.08.02.21261452
https://doi.org/10.1101/2021.08.02.21261452