Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Pavla Perlíková"'
Autor:
Zdeněk Vavřina, Pavla Perlíková, Nemanja Milisavljević, Florian Chevrier, Miroslav Smola, Joshua Smith, Milan Dejmek, Vojtěch Havlíček, Miloš Buděšínský, Radek Liboska, Lenka Vaneková, Jiří Brynda, Evzen Boura, Pavlína Řezáčová, Michal Hocek, Gabriel Birkuš
Publikováno v:
Journal of Medicinal Chemistry. 65:14082-14103
Cyclic dinucleotides (CDNs) are second messengers that activate stimulator of interferon genes (STING). The cGAS-STING pathway plays a promising role in cancer immunotherapy. Here, we describe the synthesis of CDNs containing 7-substituted 7-deazapur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc699db0a58f8c3583118679a461959
https://doi.org/10.1021/acs.jmedchem.2c01305
https://doi.org/10.1021/acs.jmedchem.2c01305
Autor:
Pavla Perlíková, Marian Hajduch, Blanka Klepetářová, Martina Medvedíková, Nemanja Milisavljevic, Helena Mertlíková-Kaiserová, Petr Džubák, Barbora Lišková, Jana Trylčová, Eva Tloušťová, Radek Pohl, Michal Tichý, Michal Hocek, Ondřej Hodek, Lucia Veselovská, Soňa Gurská, Natálie Kudlová
Publikováno v:
Chemistry – A European Journal. 26:13002-13015
All four isomeric series of novel 4-substituted pyrido-fused 7-deazapurine ribonucleosides possessing the pyridine nitrogen atom at different positions were designed and synthesized. The total synthesis of each isomeric fused heterocycle through mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc07fdfb9d5d82341afc0bcd299b3771
https://doi.org/10.1002/chem.202001124
https://doi.org/10.1002/chem.202001124
Publikováno v:
Organic & Biomolecular Chemistry. 16:5800-5807
We synthesized a small library of eighteen 5-substituted pyrimidine or 7-substituted 7-deazapurine nucleoside triphosphates bearing methyl, ethynyl, phenyl, benzofuryl or dibenzofuryl groups through cross-coupling reactions of nucleosides followed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df6f0674bdc6df788921d21cab1cd87
https://doi.org/10.1039/c8ob01498a
https://doi.org/10.1039/c8ob01498a
Autor:
Pavla Perlíková, Michal Hocek
Publikováno v:
Medicinal Research Reviews
7‐Deazapurine (pyrrolo[2,3‐d]pyrimidine) nucleosides are important analogues of biogenic purine nucleosides with diverse biological activities. Replacement of the N7 atom with a carbon atom makes the five‐membered ring more electron rich and br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3182343cbb04c21fdd11068246b90b32
https://doi.org/10.1002/med.21465
https://doi.org/10.1002/med.21465
Autor:
Petr Nauš, Pavla Perlíková, Sabina Smoleń, Magdaléna Cebová, Lenka Poštová Slavětínská, Nazarii Sabat, Michal Hocek
Publikováno v:
Synthesis. 49:4623-4650
A series of 7-(het)aryl-7-deazapurine nucleobases (5-[(het)aryl]-2,4-disubstituted 7H-pyrrolo[2,3-d]pyrimidines) bearing NH2, OMe, SMe, or Me groups at position 6 and H, NH2, or Me at position 2 were prepared by the aqueous Suzuki–Miyaura cross-cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bb06eb9256d148f7af9ead515c44dfe
https://doi.org/10.1055/s-0036-1588443
https://doi.org/10.1055/s-0036-1588443
Publikováno v:
Bioconjugate chemistry. 30(11)
A set of 41 glycosidic conjugates of pentacyclic triterpenes was synthesized in order to improve the solubility of highly cytotoxic parent compounds. Their in vitro cytotoxic activity was evaluated...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f928032b25f7974db8a15e6ca9d28a8
https://pubmed.ncbi.nlm.nih.gov/31553559
https://pubmed.ncbi.nlm.nih.gov/31553559
Autor:
Ivan Barvík, Martin Benda, Pavla Perlíková, Martina Janoušková, Hana Šanderová, Libor Krásný, Michaela Slavíčková, Nemanja Milisavljevic, Michal Hocek, Veronika Raindlová, Soňa Boháčová
Publikováno v:
Nucleic Acids Research
DNA templates containing a set of base modifications in the major groove (5-substituted pyrimidines or 7-substituted 7-deazapurines bearing H, methyl, vinyl, ethynyl or phenyl groups) were prepared by PCR using the corresponding base-modified 2′-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a9f2a3c86a819f35e9aadf7cb4176f
https://doi.org/10.1093/nar/gkw171
https://doi.org/10.1093/nar/gkw171
Autor:
Petr Nauš, Michal Hocek, Eva Tloušťová, Lenka Poštová Slavětínská, Marian Hajduch, Olga Caletková, Jan Weber, Jan Hodek, Pavla Perlíková, Petr Džubák
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:7422-7438
The synthesis and biological activity profiling of a large series of diverse pyrrolo[2,3-d]pyrimidine 4'-C-methylribonucleosides bearing an (het)aryl group at position 4 or 5 is reported as well as the synthesis of several phosphoramidate prodrugs. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023abf1a7a9a7adb8099453431348e0f
https://doi.org/10.1016/j.bmc.2015.10.040
https://doi.org/10.1016/j.bmc.2015.10.040
Autor:
Anna Tokarenko, Petr Džubák, Sabina Smoleń, Yiqian Wenren, Rebecca R. Laposa, Marian Hajduch, Noor-Ul-Ain Khalid, Soňa Gurská, Michal Tichý, Helena Mertlíková-Kaiserová, Pavla Perlíková, Barbora Lišková, Blanka Klepetářová, Eva Tloušt’ová, Ivo Frydrych, Natálie Táborská, Radek Pohl, Michal Hocek, Lenka Poštová Slavětínská, Pawel Znojek
Publikováno v:
Journal of Medicinal Chemistry
Three series of isomeric pyrrolo- and furo-fused 7-deazapurine ribonucleosides were synthesized and screened for cytostatic and antiviral activity. The synthesis was based on heterocyclizations of hetaryl-azidopyrimidines to form the tricyclic hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213346075a6778bef16bc04d7838a5c1
https://pubmed.ncbi.nlm.nih.gov/30681330
https://pubmed.ncbi.nlm.nih.gov/30681330
Autor:
Petr Konečný, Milan Kolář, Eva Tloušt’ová, Pavla Perlíková, Marian Hajduch, Petr Nauš, Petr Džubák, Michal Hocek, Lenka Poštová Slavětínská, Jana Vrbkova, Kateřina Bogdanová, Olga Caletková
Publikováno v:
Journal of Medicinal Chemistry. 57:1097-1110
A series of 80 7-(het)aryl- and 7-ethynyl-7-deazapurine ribonucleosides bearing a methoxy, methylsulfanyl, methylamino, dimethylamino, methyl, or oxo group at position 6, or 2,6-disubstituted derivatives bearing a methyl or amino group at position 2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4508629ba29b842e09ee78d18f89cf
https://doi.org/10.1021/jm4018948
https://doi.org/10.1021/jm4018948