Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Pavla Fajtová"'
Autor:
Luïse Robbertse, Pavla Fajtová, Pavla Šnebergerová, Marie Jalovecká, Viktoriya Levytska, Elany Barbosa da Silva, Vandna Sharma, Petr Pachl, Jehad Almaliti, Momen Al-Hindy, William H. Gerwick, Evžen Bouřa, Anthony J. O’Donoghue, Daniel Sojka
Publikováno v:
ACS Omega, Vol 9, Iss 45, Pp 44989-44999 (2024)
Externí odkaz:
https://doaj.org/article/6c3cefb9eda94ba2be9cb424c6745e01
Autor:
Raphael Reher, Allegra T. Aron, Pavla Fajtová, Paolo Stincone, Berenike Wagner, Alicia I. Pérez-Lorente, Chenxi Liu, Ido Y. Ben Shalom, Wout Bittremieux, Mingxun Wang, Kyowon Jeong, Marie L. Matos-Hernandez, Kelsey L. Alexander, Eduardo J. Caro-Diaz, C. Benjamin Naman, J. H. William Scanlan, Phil M. M. Hochban, Wibke E. Diederich, Carlos Molina-Santiago, Diego Romero, Khaled A. Selim, Peter Sass, Heike Brötz-Oesterhelt, Chambers C. Hughes, Pieter C. Dorrestein, Anthony J. O’Donoghue, William H. Gerwick, Daniel Petras
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Bioactivity-guided isolation of specialized metabolites is an iterative process. Here, the authors demonstrate a native metabolomics approach that allows for fast screening of complex metabolite extracts against a protein of interest and simultaneous
Externí odkaz:
https://doaj.org/article/b4de9418b20d4c4ebe6ea5392f4b3a2b
Autor:
Ittipat Meewan, Jacob Kattoula, Julius Y. Kattoula, Danielle Skinner, Pavla Fajtová, Miriam A. Giardini, Brendon Woodworth, James H. McKerrow, Jair Lage de Siqueira-Neto, Anthony J. O’Donoghue, Ruben Abagyan
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 744 (2022)
One inhibitor of the main SARS-CoV-2 protease has been approved recently by the FDA, yet it targets only SARS-CoV-2 main protease (Mpro). Here, we discovered inhibitors containing thiuram disulfide or dithiobis-(thioformate) tested against three key
Externí odkaz:
https://doaj.org/article/657345c2310e45a7868c20618d38774e
Autor:
Adrian Leontovyč, Lenka Ulrychová, Anthony J O'Donoghue, Jiří Vondrášek, Lucie Marešová, Martin Hubálek, Pavla Fajtová, Marta Chanová, Zhenze Jiang, Charles S Craik, Conor R Caffrey, Michael Mareš, Jan Dvořák, Martin Horn
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 4, p e0006446 (2018)
BACKGROUND:Serine proteases are important virulence factors for many pathogens. Recently, we discovered a group of trypsin-like serine proteases with domain organization unique to flatworm parasites and containing a thrombospondin type 1 repeat (TSR-
Externí odkaz:
https://doaj.org/article/fd9a30c7310c4f6b87532160c1ad348f
Autor:
Pavla Fajtová, Saša Štefanić, Martin Hradilek, Jan Dvořák, Jiří Vondrášek, Adéla Jílková, Lenka Ulrychová, James H McKerrow, Conor R Caffrey, Michael Mareš, Martin Horn
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003827 (2015)
Blood flukes of the genus Schistosoma cause schistosomiasis, a parasitic disease that infects over 240 million people worldwide, and for which there is a need to identify new targets for chemotherapeutic interventions. Our research is focused on Schi
Externí odkaz:
https://doaj.org/article/22076b38bc044fd5bb9ceba19797d471
Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'.
Autor:
Martin Horn, Pavla Fajtová, Liliana Rojo Arreola, Lenka Ulrychová, Pavla Bartošová-Sojková, Zdeněk Franta, Anna V Protasio, David Opavský, Jiří Vondrášek, James H McKerrow, Michael Mareš, Conor R Caffrey, Jan Dvořák
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 3, p e2766 (2014)
Blood flukes (Schistosoma spp.) are parasites that can survive for years or decades in the vasculature of permissive mammalian hosts, including humans. Proteolytic enzymes (proteases) are crucial for successful parasitism, including aspects of invasi
Externí odkaz:
https://doaj.org/article/f197c6db9e5a49f6bfbed8491c1a4ad3
Autor:
Zhicheng Jin, Justin Yeung, Jiajing Zhou, Maurice Retout, Wonjun Yim, Pavla Fajtová, Bryan Gosselin, Ivan Jabin, Gilles Bruylants, Hedi Mattoussi, Anthony J. O’Donoghue, Jesse V. Jokerst
Publikováno v:
ACS Applied Materials & Interfaces. 15:20483-20494
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2e598779a086de655ff2bb5e38239d1
https://doi.org/10.1021/acsami.3c00862
https://doi.org/10.1021/acsami.3c00862
Autor:
Yu-Ci Chang, Zhicheng Jin, Ke Li, Jiajing Zhou, Wonjun Yim, Justin Yeung, Yong Cheng, Maurice Retout, Matthew N. Creyer, Pavla Fajtová, Tengyu He, Xi Chen, Anthony J. O’Donoghue, Jesse V. Jokerst
Publikováno v:
Chemical science, vol 14, iss 10
Electrostatic interactions are a key driving force that mediates colloidal assembly. The Schulze-Hardy rule states that nanoparticles have a higher tendency to coagulate in the presence of counterions with high charge valence. However, it is unclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eff078f1ffc4eb16de6e8f3f533e80c
https://doi.org/10.1039/d2sc05837e
https://doi.org/10.1039/d2sc05837e
Autor:
Ming Xu, Jiajing Zhou, Yong Cheng, Zhicheng Jin, Alex E. Clark, Tengyu He, Wonjun Yim, Yi Li, Yu-Ci Chang, Zhuohong Wu, Pavla Fajtová, Anthony J. O’Donoghue, Aaron F. Carlin, Michael D. Todd, Jesse V. Jokerst
Publikováno v:
Analytical chemistry, vol 94, iss 34
Existing tools to detect and visualize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suffer from low selectivity, poor cell permeability, and high cytotoxicity. Here we report a novel self-immolative fluorescent probe (MP590) for the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c111b404730de951146f44d9169699
https://doi.org/10.1021/acs.analchem.2c02381
https://doi.org/10.1021/acs.analchem.2c02381
Autor:
Lucianna H. Santos, Thales Kronenberger, Renata G. Almeida, Elany B. Silva, Rafael E. O. Rocha, Joyce C. Oliveira, Luiza V. Barreto, Danielle Skinner, Pavla Fajtová, Miriam A. Giardini, Brendon Woodworth, Conner Bardine, André L. Lourenço, Charles S. Craik, Antti Poso, Larissa M. Podust, James H. McKerrow, Jair L. Siqueira-Neto, Anthony J. O’Donoghue, Eufrânio N. da Silva Júnior, Rafaela S. Ferreira
Publikováno v:
Journal of Chemical Information and Modeling. 62:6553-6573
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b61268fbedf872a1505cd162a57177b
https://doi.org/10.1021/acs.jcim.2c00693
https://doi.org/10.1021/acs.jcim.2c00693