Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Pavlína Šimečková"'
Autor:
Petra Straková, Petr Bednář, Jan Kotouček, Jiří Holoubek, Andrea Fořtová, Pavel Svoboda, Michal Štefánik, Ivana Huvarová, Pavlína Šimečková, Josef Mašek, Daniil A. Gvozdev, Igor E. Mikhnovets, Alexey A. Chistov, Timofei D. Nikitin, Maxim S. Krasilnikov, Alexey V. Ustinov, Vera A. Alferova, Vladimir A. Korshun, Daniel Růžek, Luděk Eyer
Publikováno v:
Virus Research, Vol 334, Iss , Pp 199158- (2023)
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted great interest in novel broad-spectrum antivirals, including perylene-related compounds. In the present study, we p
Externí odkaz:
https://doaj.org/article/fd0ab337342043389ef0ffe6c5160678
Autor:
František Hubatka, Radim Skoupý, Stuart Macaulay, Petr Ashcheulov, Pavel Kulich, Ladislav Fekete, Tereza Svadlakova, Milan Raska, Vladislav Krzyžánek, Miroslav Machala, Pavlína Šimečková, Irena Kratochvílová, Michael Katzuba, Pavlína Turánek Knotigová, Jan Kotouček, Eliška Bartheldyová, Naděžda Vaškovicová, Josef Mašek, Jan Krejsek, Jaroslav Turánek
Publikováno v:
Molecular Pharmaceutics. 16:3441-3451
Nanodiamonds (ND), especially fluorescent NDs, represent potentially applicable drug and probe carriers for in vitro/in vivo applications. The main purpose of this study was to relate physical-chemical properties of carboxylated NDs to their intracel
Autor:
Kateřina Pěnčíková, Miroslav Machala, Ondrej Kováč, Martina Pařenicová, Pavlína Šimečková, Jan Vondráček, Josef Slavík
Publikováno v:
Science of The Total Environment. 815:151967
Polycyclic aromatic hydrocarbons (PAHs) may interact with multiple intracellular receptors and related signaling pathways. We comprehensively evaluated the toxicity profiles of six environmentally relevant PAHs differing in structure, genotoxicity an
Autor:
Alena Vrablikova, Martina Fojtikova, Renata Hezova, Pavlina Simeckova, Veronika Brezani, Nicol Strakova, Martin Fraiberk, Jan Kotoucek, Josef Masek, Ivan Psikal
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Ultraviolet irradiation is an effective method of virus and bacteria inactivation. The dose of UV-C light necessary for baculovirus inactivation by measurement of fluorescent GFP protein produced by baculovirus expression system after the ir
Externí odkaz:
https://doaj.org/article/2fa0d1af52a041deaed64daed2b96981
Autor:
Pavlína Šimečková, Radka Vankova, Pavel Kulich, František Hubatka, Martin Motola, Petra Vicherkova, Martina Kolackova, Jan Krejsek, Pavlína Turánek Knotigová, Milan Raska, Jaroslav Turánek, Tereza Svadlakova, Jan Kotouček, Zdenek Fiala, Adriele Prina-Mello, Irena Kratochvílová, Yuri Volkov, Andrea Malkova, Martin Kalbac, Jan M. Macak, Josef Mašek
Publikováno v:
Nanomaterials
Nanomaterials, Vol 10, Iss 3, p 418 (2020)
Volume 10
Issue 3
Nanomaterials, Vol 10, Iss 3, p 418 (2020)
Volume 10
Issue 3
Carbon-based nanomaterials (C-BNM) have recently attracted an increased attention as the materials with potential applications in industry and medicine. Bioresistance and proinflammatory potential of C-BNM is the main obstacle for their medicinal app
Autor:
Pavel Kulich, Soňa Marvanová, Miroslav Machala, Jiřina Procházková, Jiří Neča, Pavlína Šimečková, Lucie Králiková
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 24
Volume 20
Issue 24
Effects of airborne particles on the expression status of markers of cellular toxic stress and on the release of eicosanoids, linked with inflammation and oxidative damage, remain poorly characterized. Therefore, we proposed a set of various methodol
Autor:
Jiřina Procházková, Jan Kotouček, Jaroslav Turánek, Josef Slavík, Kateřina Pěnčíková, Stuart Macaulay, František Hubatka, Pavlína Šimečková, Pavel Kulich, D. Hrebik, Robert Mikulik, Jiří Neča, Josef Mašek, Pavlína Turánek Knotigová, Miroslav Machala, Ondrej Kováč, Milan Raska, Jana Stráská, Pavel Diviš
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Gadolinium (Gd)–based contrast agents are extensively used for magnetic resonance imaging (MRI). Liposomes are potential nanocarrier–based biocompatible platforms for development of new generations of MRI diagnostics. Liposomes with Gd–complexe
Autor:
Jiří Kohoutek, Jiří Pacherník, Miroslav Machala, Dominika Sýkorová, Jiřina Procházková, Markéta Kabátková, Alois Kozubík, Eva Hrubá, Pavlína Šimečková, Lenka Šmerdová, Jan Vondráček
Publikováno v:
Toxicological Sciences. 134:258-270
Plakoglobin is an important component of intercellular junctions, including both desmosomes and adherens junctions, which is known as a tumor suppressor. Although mutations in the plakoglobin gene (Jup) and/or changes in its protein levels have been
Autor:
Zdeněk Andrysík, Lenka Umannová, Markéta Kabátková, Jiřina Procházková, Jan Vondráček, Jiří Kohoutek, Pavlína Šimečková, Alois Kozubík, Miroslav Machala
Publikováno v:
Archives of Toxicology. 87:491-503
The aryl hydrocarbon receptor (AhR) contributes to the control of cell-to-cell communication, cell adhesion, migration or proliferation. In the present study, we investigated the regulation of connexin43 (Cx43) and Cx43-mediated gap junctional interc
Autor:
Lenka Pálková, P.H. Cenijn, Pavlína Šimečková, Miroslav Machala, Jorke H. Kamstra, Mia Stenberg, Timo Hamers, Patrik L. Andersson, Jan Vondráček, Katerina Pencikova
Publikováno v:
Hamers, T H M, Kamstra, J H, Cenijn, P H, Palkova, L, Simeckova, P, Vondracek, J, Andersson, P L, Stenberg, M & Machala, M 2011, ' In vitro toxicity profiling of ultrapure non-dioxin-like polychlorinated biphenyl (NDL-PCB) congeners and their relative toxic contribution to PCB-mixtures in humans ', Toxicological Sciences, vol. 121, no. 1, pp. 88-100 . https://doi.org/10.1093/toxsci/kfr043
Toxicological Sciences, 121(1), 88-100. Oxford University Press
Toxicological Sciences, 121(1), 88-100. Oxford University Press
The toxic equivalency concept used for the risk assessment of polychlorinated biphenyls (PCBs) is based on the aryl hydrocarbon receptor (AhR)-mediated toxicity of coplanar dioxin-like (DL) PCBs. Most PCBs in the environment, however, are non-dioxin-