Výsledky vyhledávání - "Pavithra Premkumar"

Akademický článek

Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 2, Pp 411-428 (2019)

Abstract Background Excess reactive oxygen species (ROS) and muscle weakness occur in parallel in multiple pathological conditions. However, the causative role of skeletal muscle mitochondrial ROS (mtROS) on neuromuscular junction (NMJ) morphology an

Externí odkaz: https://doaj.org/article/bf068644f5f343948ea2be767d068283

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Akademický článek

Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness

Autor: Rizwan Qaisar, Shylesh Bhaskaran, Rojina Ranjit, Kavithalakshmi Sataranatarajan, Pavithra Premkumar, Kendra Huseman, Holly Van Remmen

Publikováno v: Redox Biology, Vol 20, Iss , Pp 68-74 (2019)

Molecular targets to reduce muscle weakness and atrophy due to oxidative stress have been elusive. Here we show that activation of Sarcoplasmic Reticulum (SR) Ca2+ ATPase (SERCA) with CDN1163, a novel small molecule allosteric SERCA activator, amelio

Externí odkaz: https://doaj.org/article/1109ff0a1f05410a8f10d187f34502b4

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Akademický článek

Oxidative stress‐induced dysregulation of excitation–contraction coupling contributes to muscle weakness

Autor: Rizwan Qaisar, Shylesh Bhaskaran, Pavithra Premkumar, Rojina Ranjit, Kavithalakshmi Satara Natarajan, Bumsoo Ahn, Kaitlyn Riddle, Dennis R. Claflin, Arlan Richardson, Susan V. Brooks, Holly Van Remmen

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 5, Pp 1003-1017 (2018)

Abstract Background We have previously shown that the deletion of the superoxide scavenger, CuZn superoxide dismutase, in mice (Sod1−/− mice) results in increased oxidative stress and an accelerated loss of skeletal muscle mass and force that mir

Externí odkaz: https://doaj.org/article/1ad724d6e92545639f0dae9a584dc46b

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Akademický článek

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

Autor: Sreemathi Logan, Gavin A. Pharaoh, M. Caleb Marlin, Dustin R. Masser, Satoshi Matsuzaki, Benjamin Wronowski, Alexander Yeganeh, Eileen E. Parks, Pavithra Premkumar, Julie A. Farley, Daniel B. Owen, Kenneth M. Humphries, Michael Kinter, Willard M. Freeman, Luke I. Szweda, Holly Van Remmen, William E. Sonntag

Publikováno v: Molecular Metabolism, Vol 9, Iss , Pp 141-155 (2018)

Objective: A decline in mitochondrial function and biogenesis as well as increased reactive oxygen species (ROS) are important determinants of aging. With advancing age, there is a concomitant reduction in circulating levels of insulin-like growth fa

Externí odkaz: https://doaj.org/article/32814f5809cb49c2965d978f0cb0172f

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Methamphetamine Self-Administration Differential Effects on Mesolimbic Glutathione Levels, Mitochondrial Respiration and Dopamine Neuron Firing Activity

Autor: Sergio Dominguez-Lopez, Bumsoo Ahn, Kavithalakshmi Sataranatarajan, Rojina Ranjit, Pavithra Premkumar, Holly Van Remmen, Michael J. Beckstead

Acute and neurotoxic regimens of METH are known to increase reactive oxygen species (ROS), affect redox homeostasis, and lead to cellular damage in dopamine neurons. However, functional changes induced by long-term METH self-administration on mitocho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b5fcc1b739dfd5899db3b022ef4abe9
https://doi.org/10.1101/2022.09.12.507550

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Molecular changes associated with spinal cord aging

Autor: Holly Van Remmen, Michelle Zalles, Debra Saunders, Jaime L. Laurin, Rheal A. Towner, Shadi Khademi, Shylesh Bhaskaran, Pavithra Premkumar, Rick Peelor, Katarzyna M. Piekarz, Benjamin F. Miller, Kavithalakshmi Sataranatarajan, Rafal Gulej, Kaitlyn Street

Publikováno v: GeroScience

Age-related muscle weakness and loss of muscle mass (sarcopenia) is a universal problem in the elderly. Our previous studies indicate that alpha motor neurons (α-MNs) play a critical role in this process. The goal of the current study is to uncover

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59de5702e5a3c923173b1f592bd31c3
https://doi.org/10.1007/s11357-020-00172-6

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Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 2, Pp 411-428 (2019)

Background Excess reactive oxygen species (ROS) and muscle weakness occur in parallel in multiple pathological conditions. However, the causative role of skeletal muscle mitochondrial ROS (mtROS) on neuromuscular junction (NMJ) morphology and functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4b62f064c329bb06a7c60427fae15d
https://doi.org/10.1002/jcsm.12375

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Oxidative stress-induced dysregulation of excitation-contraction coupling contributes to muscle weakness

Autor: Kaitlyn Riddle, Pavithra Premkumar, Shylesh Bhaskaran, Bumsoo Ahn, Rojina Ranjit, Arlan Richardson, Susan V. Brooks, Kavithalakshmi Satara Natarajan, Rizwan Qaisar, Holly Van Remmen, Dennis R. Claflin

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle. 9:1003-1017

Background We have previously shown that the deletion of the superoxide scavenger, CuZn superoxide dismutase, in mice (Sod1-/- mice) results in increased oxidative stress and an accelerated loss of skeletal muscle mass and force that mirror the chang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d450f0708ff2b8342adf1c5ae3ea225e
https://doi.org/10.1002/jcsm.12339

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