VCE‐004.3, a cannabidiol aminoquinone derivative, prevents bleomycin‐induced skin fibrosis and inflammation through PPARγ‐ and CB(2) receptor‐dependent pathways

Autor: del Rio, Carmen, Cantarero, Irene, Palomares, Belén, Gómez‐Cañas, María, Fernández‐Ruiz, Javier, Pavicic, Carolina, García‐Martín, Adela, Luz Bellido, Maria, Ortega‐Castro, Rafaela, Pérez‐Sánchez, Carlos, López‐Pedrera, Chary, Appendino, Giovanni, Calzado, Marco A, Muñoz, Eduardo

BACKGROUND AND PURPOSE: The endocannabinoid system and PPARγ are important targets for the development of novel compounds against fibrotic diseases such as systemic sclerosis (SSc), also called scleroderma. The aim of this study was to characterize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8fdf0def3ac7b9a00ded47df6e8421e
https://europepmc.org/articles/PMC6135789/

Additional file 2: Figure S2. of Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson’s disease: possible involvement of different binding sites at the PPARγ receptor

Autor: García, Concepción, Gómez-Cañas, María, Burgaz, Sonia, Palomares, Belén, Gómez-Gálvez, Yolanda, Palomo-Garo, Cristina, Campo, Sara, Ferrer-Hernández, Joel, Pavicic, Carolina, Navarrete, Carmen, M. Luz Bellido, García-Arencibia, Moisés, M. Ruth Pazos, Muñoz, Eduardo, Fernández-Ruiz, Javier

BV2 cells were seeded at 1 × 105 in 60-mm dishes and 24 h later treated with RGZ or VCE-003.2 in the absence or the presence of LPS (50 ng/mL) for 6 h and the steady state levels of endogenous PPARγ and β-actin detected by western blot (PDF 105 kb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fcbfe991d75d9c17fee51f14cf2a0d

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VCE-004.3, a cannabidiol aminoquinone derivative, prevents bleomycin-induced skin fibrosis and inflammation through PPARγ- and CB2 receptor-dependent pathways.

Autor: del Rio, Carmen, Cantarero, Irene, Palomares, Belén, Gómez‐Cañas, María, Fernández‐Ruiz, Javier, Pavicic, Carolina, García‐Martín, Adela, Luz Bellido, Maria, Ortega‐Castro, Rafaela, Pérez‐Sánchez, Carlos, López‐Pedrera, Chary, Appendino, Giovanni, Calzado, Marco A., Muñoz, Eduardo, Gómez-Cañas, María, Fernández-Ruiz, Javier, García-Martín, Adela, Ortega-Castro, Rafaela, Pérez-Sánchez, Carlos, López-Pedrera, Chary

Publikováno v: British Journal of Pharmacology; Oct2018, Vol. 175 Issue 19, p3813-3831, 19p, 8 Color Photographs, 1 Black and White Photograph, 1 Chart, 3 Graphs