A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes.

Autor: Heshan Peiris, Michael D Duffield, Joao Fadista, Claire F Jessup, Vinder Kashmir, Amanda J Genders, Sean L McGee, Alyce M Martin, Madiha Saiedi, Nicholas Morton, Roderick Carter, Michael A Cousin, Alexandros C Kokotos, Nikolay Oskolkov, Petr Volkov, Tertius A Hough, Elizabeth M C Fisher, Victor L J Tybulewicz, Jorge Busciglio, Pinar E Coskun, Ann Becker, Pavel V Belichenko, William C Mobley, Michael T Ryan, Jeng Yie Chan, D Ross Laybutt, P Toby Coates, Sijun Yang, Charlotte Ling, Leif Groop, Melanie A Pritchard, Damien J Keating

Publikováno v: PLoS Genetics, Vol 12, Iss 5, p e1006033 (2016)

Type 2 diabetes (T2D) is a complex metabolic disease associated with obesity, insulin resistance and hypoinsulinemia due to pancreatic β-cell dysfunction. Reduced mitochondrial function is thought to be central to β-cell dysfunction. Mitochondrial

Externí odkaz: https://doaj.org/article/55d1108814ad40e3b162e4623311cfe8

Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.

Autor: Pavel V Belichenko, Alexander M Kleschevnikov, Ann Becker, Grant E Wagner, Larisa V Lysenko, Y Eugene Yu, William C Mobley

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0134861 (2015)

Down syndrome (DS), trisomy for chromosome 21, is the most common genetic cause of intellectual disability. The genomic regions on human chromosome 21 (HSA21) are syntenically conserved with regions on mouse chromosomes 10, 16, and 17 (Mmu10, Mmu16,

Externí odkaz: https://doaj.org/article/d51c038fdc8148899fbd97c4cd544d85

Orals

Autor: Pinar Coskun, Damien J. Keating, Michael D. Duffield, Claire F. Jessup, William C. Mobley, Sean L. McGee, Victor L. J. Tybulewicz, Tertius Hough, Pavel V. Belichenko, João Fadista, Amanda J Genders, Penelope Coates, Melanie April Pritchard, Jorge Busciglio, Ann Becker, Elizabeth M. C. Fisher, Heshan Peiris, Ross Laybutt

Publikováno v: Diabetes. 64:A1-A100

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f65b4c60e947939cc727eec0c380290
https://doi.org/10.2337/db15-1-385

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes

Autor: Ann Becker, Pinar Coskun, Petr Volkov, Vinder Kashmir, Nikolay Oskolkov, Claire F. Jessup, Heshan Peiris, Michael T. Ryan, William C. Mobley, Amanda J Genders, Nicholas M. Morton, Alyce M. Martin, D. Ross Laybutt, Michael D. Duffield, Michael A. Cousin, João Fadista, Jeng Yie Chan, Sean L. McGee, Leif Groop, Alexandros C. Kokotos, Victor L. J. Tybulewicz, Tertius Hough, Elizabeth M. C. Fisher, Melanie April Pritchard, Jorge Busciglio, P. Toby Coates, Roderick N. Carter, Charlotte Ling, Madiha Saiedi, Sijun Yang, Pavel V. Belichenko, Damien J. Keating

Publikováno v: Peiris, H; Duffield, MD; Fadista, J; Jessup, CF; Kashmir, V; Genders, AJ; et al.(2016). A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS Genetics, 12(5). doi: 10.1371/journal.pgen.1006033. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/69g1d108
Peiris, H, Duffield, M D, Fadista, J, Jessup, C F, Kashmir, V, Genders, A J, McGee, S L, Martin, A M, Saiedi, M, Morton, N, Carter, R, Cousin, M A, Kokotos, A, Oskolkov, N, Volkov, P, Hough, T A, Fisher, E M C, Tybulewicz, V L J, Busciglio, J, Coskun, P E, Becker, A, Belichenko, P V, Mobley, W C, Ryan, M T, Chan, J Y, Laybutt, D R, Coates, P T, Yang, S, Ling, C, Groop, L, Pritchard, M A & Keating, D J 2016, ' A syntenic cross species aneuploidy genetic screen links RCAN1 expression to β-cell mitochondrial dysfunction in Type 2 diabetes ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1006033
PLoS Genetics, Vol 12, Iss 5, p e1006033 (2016)
PLoS Genetics

Type 2 diabetes (T2D) is a complex metabolic disease associated with obesity, insulin resistance and hypoinsulinemia due to pancreatic β-cell dysfunction. Reduced mitochondrial function is thought to be central to β-cell dysfunction. Mitochondrial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a79e00f46b9b13910b1e47b75ca457
http://www.escholarship.org/uc/item/69g1d108

Deficits in Cognition and Synaptic Plasticity in a Mouse Model of Down Syndrome Ameliorated by GABAB Receptor Antagonists

Autor: Khin Htun, Mehrdad Faizi, Lucia F. Jacobs, Mehrdad Shamloo, Pavel V. Belichenko, William C. Mobley, Alexander M. Kleschevnikov

Publikováno v: Journal of Neuroscience. 32:9217-9227

Cognitive impairment in Down syndrome (DS) is characterized by deficient learning and memory. Mouse genetic models of DS exhibit impaired cognition in hippocampally mediated behavioral tasks and reduced synaptic plasticity of hippocampal pathways. En

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f54c918bbe3060ecff82dc9a96f76a8
https://doi.org/10.1523/jneurosci.1673-12.2012