Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Pavel V, Belichenko"'
Autor:
Heshan Peiris, Michael D Duffield, Joao Fadista, Claire F Jessup, Vinder Kashmir, Amanda J Genders, Sean L McGee, Alyce M Martin, Madiha Saiedi, Nicholas Morton, Roderick Carter, Michael A Cousin, Alexandros C Kokotos, Nikolay Oskolkov, Petr Volkov, Tertius A Hough, Elizabeth M C Fisher, Victor L J Tybulewicz, Jorge Busciglio, Pinar E Coskun, Ann Becker, Pavel V Belichenko, William C Mobley, Michael T Ryan, Jeng Yie Chan, D Ross Laybutt, P Toby Coates, Sijun Yang, Charlotte Ling, Leif Groop, Melanie A Pritchard, Damien J Keating
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006033 (2016)
Type 2 diabetes (T2D) is a complex metabolic disease associated with obesity, insulin resistance and hypoinsulinemia due to pancreatic β-cell dysfunction. Reduced mitochondrial function is thought to be central to β-cell dysfunction. Mitochondrial
Externí odkaz:
https://doaj.org/article/55d1108814ad40e3b162e4623311cfe8
Autor:
Alexander M. Kleschevnikov, Pavel V. Belichenko, Jessica Gall, Lizzy George, Rachel Nosheny, Michael T. Maloney, Ahmad Salehi, William C. Mobley
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 2, Pp 683-691 (2012)
Cognitive impairment in Down syndrome (DS) involves the hippocampus. In the Ts65Dn mouse model of DS, deficits in hippocampus-dependent learning and synaptic plasticity were linked to enhanced inhibition. However, the mechanistic basis of changes in
Externí odkaz:
https://doaj.org/article/93792ac3bc0f4369b25a6d8cbb880d2c
Publikováno v:
Neurobiology of Disease, Vol 34, Iss 1, Pp 71-77 (2009)
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the gene MECP2, encoding methyl-CpG-binding protein 2 (MeCP2). Few studies have explored dendritic morphology phenotypes in mouse models of RTT and none have determ
Externí odkaz:
https://doaj.org/article/3dcf63326232432fa9e343717d0033e3
Autor:
Pavel V Belichenko, Rime Madani, Lorianne Rey-Bellet, Maria Pihlgren, Ann Becker, Adeline Plassard, Stephanie Vuillermot, Valérie Giriens, Rachel L Nosheny, Alexander M Kleschevnikov, Janice S Valletta, Sara K S Bengtsson, Gordon R Linke, Michael T Maloney, David T Hickman, Pedro Reis, Anne Granet, Dorin Mlaki, Maria Pilar Lopez-Deber, Long Do, Nishant Singhal, Eliezer Masliah, Matthew L Pearn, Andrea Pfeifer, Andreas Muhs, William C Mobley
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152471 (2016)
In Down syndrome (DS) or trisomy of chromosome 21, the β-amyloid (Aβ) peptide product of the amyloid precursor protein (APP) is present in excess. Evidence points to increased APP gene dose and Aβ as playing a critical role in cognitive difficulti
Externí odkaz:
https://doaj.org/article/e6e5615e619c41a0ad64eafb049c71c7
Autor:
Pavel V Belichenko, Alexander M Kleschevnikov, Ann Becker, Grant E Wagner, Larisa V Lysenko, Y Eugene Yu, William C Mobley
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134861 (2015)
Down syndrome (DS), trisomy for chromosome 21, is the most common genetic cause of intellectual disability. The genomic regions on human chromosome 21 (HSA21) are syntenically conserved with regions on mouse chromosomes 10, 16, and 17 (Mmu10, Mmu16,
Externí odkaz:
https://doaj.org/article/d51c038fdc8148899fbd97c4cd544d85
Publikováno v:
Neurobiology of Disease, Vol 6, Iss 4, Pp 269-279 (1999)
GABA-interneurons immunoreactive (IR) for the calcium-binding protein parvalbumin are lost during the early stages of Creutzfeldt-Jakob disease (CJD) and diminution in their number may partially account for the neurological disturbances manifested in
Externí odkaz:
https://doaj.org/article/f2d269d36bb445bfbff72dd90278ac73
Publikováno v:
Neurobiology of Disease, Vol 6, Iss 2, Pp 77-91 (1999)
Entorhinal cortex (EC), fascia dentata (FD), hippocampus (HP), and basal ganglia (BG) were studied in Rett syndrome (RS) cases and compared with control brains and an autism case. Kluver–Barrera and Golgi methods were used. In RS most of the areas
Externí odkaz:
https://doaj.org/article/686bad56f7c54c90a0731599b867120e
Publikováno v:
Neurobiology of Disease, Vol 4, Iss 3, Pp 301-310 (1997)
Neurological dysfunction is not uncommon in patients suffering from acquired immunodeficiency syndrome (AIDS) and, when manifested, intimates involvement of the central nervous system. Here, the human immunodeficiency virus (HIV) infects preferential
Externí odkaz:
https://doaj.org/article/99d111ce15404de58823bac46caa5d18
Autor:
Sarah Wie, Alexander M. Kleschevnikov, William C. Mobley, Kai Meng, Zhuo Xing, Tao Yu, Xiaoling Jiang, Annie Pao, Y. Eugene Yu, Pavel V. Belichenko, Li Zhang, Chunhong Liu, Jennifer Peresie
Publikováno v:
Human Molecular Genetics. 24:6540-6551
Down syndrome (DS), caused by trisomy 21, is the most common chromosomal disorder associated with developmental cognitive deficits. Despite intensive efforts, the genetic mechanisms underlying developmental cognitive deficits remain poorly understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe27eb20fecd99f8934be85b8c3306d
https://doi.org/10.1093/hmg/ddv364
https://doi.org/10.1093/hmg/ddv364
Autor:
Pinar Coskun, Damien J. Keating, Michael D. Duffield, Claire F. Jessup, William C. Mobley, Sean L. McGee, Victor L. J. Tybulewicz, Tertius Hough, Pavel V. Belichenko, João Fadista, Amanda J Genders, Penelope Coates, Melanie April Pritchard, Jorge Busciglio, Ann Becker, Elizabeth M. C. Fisher, Heshan Peiris, Ross Laybutt
Publikováno v:
Diabetes. 64:A1-A100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f65b4c60e947939cc727eec0c380290
https://doi.org/10.2337/db15-1-385
https://doi.org/10.2337/db15-1-385