Výsledky vyhledávání - "Pavel Tchelidze"

Akademický článek

Nucleolar sub-compartments in motion during rRNA synthesis inhibition: Contraction of nucleolar condensed chromatin and gathering of fibrillar centers are concomitant.

Autor: Pavel Tchelidze, Aassif Benassarou, Hervé Kaplan, Marie-Françoise O'Donohue, Laurent Lucas, Christine Terryn, Levan Rusishvili, Giorgi Mosidze, Nathalie Lalun, Dominique Ploton

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0187977 (2017)

The nucleolus produces the large polycistronic transcript (47S precursor) containing the 18S, 5.8S and 28S rRNA sequences and hosts most of the nuclear steps of pre-rRNA processing. Among numerous components it contains condensed chromatin and active

Externí odkaz: https://doaj.org/article/cef43c67e5174e498ad8442b4c32837a

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Akademický článek

Stage-Specific Changes in the Water, Na+, Cl- and K+ Contents of Organelles during Apoptosis, Demonstrated by a Targeted Cryo Correlative Analytical Approach.

Autor: Frédérique Nolin, Jean Michel, Laurence Wortham, Pavel Tchelidze, Vincent Banchet, Nathalie Lalun, Christine Terryn, Dominique Ploton

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0148727 (2016)

Many studies have demonstrated changes in the levels of several ions during apoptosis, but a few recent studies have reported conflicting results concerning the changes in water content in apoptotic cells. We used a correlative light and cryo-scannin

Externí odkaz: https://doaj.org/article/0bb46a4500c14a939ad24aa38e2d4513

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Various Nucleolar Stress Inducers Result in Highly Distinct Changes in Water, Dry Mass and Elemental Content in Cancerous Cell Compartments: Investigation Using a Nano-Analytical Approach

Autor: Dominique Ploton, Frédérique Nolin, Vincent Banchet, Pavel Tchelidze, Christine Terryn, Laurence Wortham, Nathalie Lalun, Jean Michel

Publikováno v: Nanotheranostics

Rationale: Numerous chemotherapeutic drugs that affect ribosome biogenesis in the nucleolus induce nucleolar stress. Improving our understanding of the effects of these drugs will require uncovering and comparing their impact on several biophysical p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc37e8e0587bf53e6afb479a9a27e5f
http://europepmc.org/articles/PMC6536780

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Electron tomography reveals changes in spatial distribution of UBTF1 and UBTF2 isoforms within nucleolar components during rRNA synthesis inhibition

Autor: Marc Thiry, Christine Terryn, Pavel Tchelidze, Dominique Ploton, Nathalie Lalun, Hervé Kaplan

Publikováno v: Journal of structural biology. 208(2)

Upstream binding transcription factor (UBTF) is a co-regulator of RNA polymerase I by constituting an initiation complex on rRNA genes. UBTF plays a role in rDNA bending and its maintenance in "open" state. It exists as two splicing variants, UBTF1 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25da855d86285839e691ef10cee0d0ef
https://pubmed.ncbi.nlm.nih.gov/31479756

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Targeted nano analysis of water and ions in the nucleus using cryo-correlative microscopy

Autor: Frédérique, Nolin, Dominique, Ploton, Laurence, Wortham, Pavel, Tchelidze, Hélène, Bobichon, Vincent, Banchet, Nathalie, Lalun, Christine, Terryn, Jean, Michel

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1228

The cell nucleus is a crowded volume in which the concentration of macromolecules is high. These macromolecules sequester most of the water molecules and ions which, together, are very important for stabilization and folding of proteins and nucleic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9783062c698671c841997391f482fc00
https://pubmed.ncbi.nlm.nih.gov/25311128

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Targeted Nano Analysis of Water and Ions in the Nucleus Using Cryo-Correlative Microscopy

Autor: Hélène Bobichon, Nathalie Lalun, Jean Michel, Laurence Wortham, Vincent Banchet, Dominique Ploton, Pavel Tchelidze, Christine Terryn, Frédérique Nolin

Publikováno v: The Nucleus ISBN: 9781493916795

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d54b20986ab4677f06b6c5bd71c57402
https://doi.org/10.1007/978-1-4939-1680-1_12

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Changes to cellular water and element content induced by nucleolar stress: investigation by a cryo-correlative nano-imaging approach

Autor: Frédérique Nolin, Dominique Ploton, Vincent Banchet, Gérard Balossier, Laurence Wortham, Hélène Bobichon, Christine Terryn, Nathalie Lalun, Jean Michel, Pavel Tchelidze

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2013, 70 (13), pp.2383-2394

The cell is a crowded volume, with estimated mean mass percentage of macromolecules and of water ranging from 7.5 to 45 and 55 to 92.5 %, respectively. However, the concentrations of macromolecules and water at the nanoscale within the various cell c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27216b9919474f8724902870887dae19
https://hal.archives-ouvertes.fr/hal-00861224

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Stage-Specific Changes in the Water, Na+, Cl- and K+ Contents of Organelles during Apoptosis, Demonstrated by a Targeted Cryo Correlative Analytical Approach

Autor: Nathalie Lalun, Jean Michel, Laurence Wortham, Frédérique Nolin, Christine Terryn, Pavel Tchelidze, Dominique Ploton, Vincent Banchet

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0148727 (2016)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd45d8ebe14e5efad0875c3ed19a5351
https://doi.org/10.1371/journal.pone.0148727

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Targeted nano analysis of water and ions using cryocorrelative light and scanning transmission electron microscopy

Autor: Hélène Bobichon, Pavel Tchelidze, Nathalie Lalun, Vincent Banchet, Gérard Balossier, Frédérique Nolin, Jean Michel, Laurence Wortham, Christine Terryn, Dominique Ploton

Publikováno v: Journal of Structural Biology
Journal of Structural Biology, Elsevier, 2012, 180 (2), pp.352-361

Cryo fluorescence imaging coupled with the cryo-EM technique (cryo-CLEM) avoids chemical fixation and embedding in plastic, and is the gold standard for correlated imaging in a close to native state. This multi-modal approach has not previously inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcd13f57cc73ddc4ef1d8408a984445
https://hal.archives-ouvertes.fr/hal-00752393

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Tomography of the cell nucleus using confocal microscopy and medium voltage electron microscopy

Autor: Pavel Tchelidze, Aurore Chatron-Colliet, Natahlie Lalun, Dominique Ploton, Marc Thiry, Hélène Bobichon

Publikováno v: Critical Reviews in Oncology/Hematology
Critical Reviews in Oncology/Hematology, Elsevier, 2009, 69 (2), pp.127-143

Changes in nuclear structures are widely used by pathologists as diagnostic and prognostic indicators in cancer cells. Recent studies have demonstrated that the cell nucleus is probably the most complex organelle in the cell. It contains the genome a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbec74fd5f42e83d9aceeba046da0a8
https://hal.archives-ouvertes.fr/hal-00355901

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