Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Pavel Sumazin"'
Autor:
András H. Lékó, Adriana Gregory-Flores, Renata C. N. Marchette, Juan L. Gomez, Janaina C. M. Vendruscolo, Vez Repunte-Canonigo, Vicky Choung, Sara L. Deschaine, Kimberly E. Whiting, Shelley N. Jackson, Maria Paula Cornejo, Mario Perello, Zhi-Bing You, Michael Eckhaus, Karuna Rasineni, Kim D. Janda, Barry Zorman, Pavel Sumazin, George F. Koob, Michael Michaelides, Pietro P. Sanna, Leandro F. Vendruscolo, Lorenzo Leggio
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract The stomach-derived hormone ghrelin regulates essential physiological functions. The ghrelin receptor (GHSR) has ligand-independent actions; therefore, GHSR gene deletion may be a reasonable approach to investigate the role of this system in
Externí odkaz:
https://doaj.org/article/69dd93baf3cc42269d69f72c7d7939c7
Autor:
Jacob J. Junco, Max Rochette, Michelle Alozie, Raushan Rashid, Maci Terrell, Barry Zorman, Pavel Sumazin, Lauren Rowland, Gino Dettorre, Reid T. Powell, Clifford C. Stephan, Peter J. Davies, Margarita Martinez-Moczygemba, Jun J. Yang, Karen R. Rabin
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Not available.
Externí odkaz:
https://doaj.org/article/590d5e704bc84918a4652e95e30f9135
Autor:
Andres F. Espinoza, Kalyani R. Patel, Priya B. Shetty, Richard S. Whitlock, Pavel Sumazin, Xinjian Yu, Stephen F. Sarabia, Martin Urbicain, Andras Heczey, Prakash Masand, Sarah E. Woodfield, Dolores H. López‐Terrada, Sanjeev A. Vasudevan
Publikováno v:
Cancer Medicine, Vol 12, Iss 23, Pp 21270-21278 (2023)
Abstract Objective Hepatoblastoma (HB) is the most common primary hepatic malignancy in childhood. Relapse occurs in more than 50% of high‐risk patients with a high mortality due to ineffective salvage therapies. The purpose of this study is to ide
Externí odkaz:
https://doaj.org/article/0c97209ea30843db8d7cf1592b8908cd
Autor:
Francisco Avila Cobos, Mohammad Javad Najaf Panah, Jessica Epps, Xiaochen Long, Tsz-Kwong Man, Hua-Sheng Chiu, Elad Chomsky, Evgeny Kiner, Michael J. Krueger, Diego di Bernardo, Luis Voloch, Jan Molenaar, Sander R. van Hooff, Frank Westermann, Selina Jansky, Michele L. Redell, Pieter Mestdagh, Pavel Sumazin
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract Background RNA profiling technologies at single-cell resolutions, including single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq, scnRNA-seq for short), can help characterize the composition of tissues and reveal cells that
Externí odkaz:
https://doaj.org/article/d4626884e3864b748b5d6fb020d26428
Autor:
Yu-Chiau Shyu, Ting-Shuo Huang, Hua-Sheng Chiu, Pavel Sumazin, Xin-Yu Lin, Po-Cheng Liao, Cai-Cin Liou, Fang-Chia Hsu, Jyuan-Siou Lin, Chih-Chin Hsu, Pang-Hung Hsu, Chi-Chin Sun, Chien-Tzung Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2373 (2024)
Negative Pressure Wound Therapy (NPWT) is a commonly employed clinical strategy for wound healing, yet its early-stage mechanisms remain poorly understood. To address this knowledge gap and overcome the limitations of human trials, we establish an NP
Externí odkaz:
https://doaj.org/article/85113515cd1642c4ac7d85cab70605ad
Autor:
Ling Tao, Mahmoud A. Mohammad, Giorgio Milazzo, Myrthala Moreno-Smith, Tajhal D. Patel, Barry Zorman, Andrew Badachhape, Blanca E. Hernandez, Amber B. Wolf, Zihua Zeng, Jennifer H. Foster, Sara Aloisi, Pavel Sumazin, Youli Zu, John Hicks, Ketan B. Ghaghada, Nagireddy Putluri, Giovanni Perini, Cristian Coarfa, Eveline Barbieri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Half of high-risk neuroblastoma patients have MYCN amplification. Here, the authors show that MYCN induces fatty acid uptake and synthesis to support neuroblastoma and inhibition of a fatty acid transporter impairs tumor progression in preclinical mo
Externí odkaz:
https://doaj.org/article/f46634316a174b53a1daa084ab8c5d23
Autor:
Sarah E. Woodfield, Brandon J. Mistretta, Roma H. Patel, Aryana M. Ibarra, Kevin E. Fisher, Stephen F. Sarabia, Ilavarasi Gandhi, Jacquelyn Reuther, Zbigniew Starosolski, Andrew Badachhape, Jessica Epps, Barry Zorman, Aayushi P. Shah, Samuel R. Larson, Rohit K. Srivastava, Yan Shi, Andres F. Espinoza, Saiabhiroop R. Govindu, Richard S. Whitlock, Kimberly Holloway, Angshumoy Roy, Pavel Sumazin, Ketan B. Ghaghada, Dolores Lopez-Terrada, Preethi H. Gunaratne, Sanjeev A. Vasudevan
Publikováno v:
Biology Open, Vol 11, Iss 9 (2022)
Hepatoblastoma (HB) is the most common pediatric primary liver malignancy, and survival for high-risk disease approaches 50%. Mouse models of HB fail to recapitulate hallmarks of high-risk disease. The aim of this work was to generate murine models t
Externí odkaz:
https://doaj.org/article/19d25bfd932e459dbc19467d36d3ca80
Autor:
Myrthala Moreno-Smith, Giorgio Milazzo, Ling Tao, Baharan Fekry, Bokai Zhu, Mahmoud A. Mohammad, Simone Di Giacomo, Roshan Borkar, Karthik Reddy Kami Reddy, Mario Capasso, Sanjeev A. Vasudevan, Pavel Sumazin, John Hicks, Nagireddy Putluri, Giovanni Perini, Kristin Eckel-Mahan, Thomas P. Burris, Eveline Barbieri
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
MYCN is frequently amplified in neuroblastomas. Here, the authors show that MYCN disrupts the molecular clock by downregulating clock activator RORα and that the reactivation of RORα restores BMAL1 activity, and inhibits lipid metabolism and neurob
Externí odkaz:
https://doaj.org/article/36f78ce6f76041c49c8161f0733a70f4
Autor:
Sarah E. Woodfield, Yan Shi, Roma H. Patel, Zhenghu Chen, Aayushi P. Shah, Richard S. Whitlock, Aryana M. Ibarra, Samuel R. Larson, Stephen F. Sarabia, Andrew Badachhape, Zbigniew Starosolski, Ketan B. Ghaghada, Pavel Sumazin, D. Allen Annis, Dolores López-Terrada, Sanjeev A. Vasudevan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Hepatoblastoma (HB) is the most common pediatric liver malignancy. High-risk patients have poor survival, and current chemotherapies are associated with significant toxicities. Targeted therapies are needed to improve outcomes and patient qu
Externí odkaz:
https://doaj.org/article/2c835b5e701047a99457ad48818f16a6
Autor:
Alexandra M. Stevens, Michael Xiang, Lisa N. Heppler, Isidora Tošić, Kevin Jiang, Jaime O. Munoz, Amos S. Gaikwad, Terzah M. Horton, Xin Long, Padmini Narayanan, Elizabeth L. Seashore, Maci C. Terrell, Raushan Rashid, Michael J. Krueger, Alicia E. Mangubat-Medina, Zachary T. Ball, Pavel Sumazin, Sarah R. Walker, Yoshimasa Hamada, Seiichi Oyadomari, Michele S. Redell, David A. Frank
Publikováno v:
Blood Advances, Vol 3, Iss 24, Pp 4215-4227 (2019)
Abstract: Atovaquone, a US Food and Drug Administration–approved antiparasitic drug previously shown to reduce interleukin-6/STAT3 signaling in myeloma cells, is well tolerated, and plasma concentrations of 40 to 80 µM have been achieved with pedi
Externí odkaz:
https://doaj.org/article/4187c59f20f14fd4af323bb29b1514a1