Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Pavel Šácha"'
Autor:
Mohammad Reza Zamani, Pavel Šácha
Publikováno v:
Heliyon, Vol 10, Iss 23, Pp e40386- (2024)
Coronavirus disease 2019 (COVID-19) is a highly contagious viral disease, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It can manifest as mild to severe flu-like and non-flu-like symptoms and signs, which are associated
Externí odkaz:
https://doaj.org/article/ea1c9a3577ce47f8aa36cd877106e742
Autor:
Anna Kertisová, Lenka Žáková, Kateřina Macháčková, Aleš Marek, Pavel Šácha, Petr Pompach, Jiří Jiráček, Irena Selicharová
Publikováno v:
Open Biology, Vol 13, Iss 11 (2023)
The insulin receptor (IR, with its isoforms IR-A and IR-B) and the insulin-like growth factor 1 receptor (IGF-1R) are related tyrosine kinase receptors. Recently, the portfolio of solved hormone–receptor structures has grown extensively thanks to a
Externí odkaz:
https://doaj.org/article/85854c8c7ff941429cf6951fa7321724
Autor:
Klára Pospíšilová, Tomáš Knedlík, Pavel Šácha, Libor Kostka, Jiří Schimer, Jiří Brynda, Vlastimil Král, Petr Cígler, Václav Navrátil, Tomáš Etrych, Vladimír Šubr, Michael Kugler, Milan Fábry, Pavlína Řezáčová, Jan Konvalinka
Publikováno v:
ACS Omega, Vol 4, Iss 4, Pp 6746-6756 (2019)
Externí odkaz:
https://doaj.org/article/f19d4dce08f848dba46628cafbb8c70d
Autor:
Petra Dzianová, Seiya Asai, Martina Chrudinová, Lucie Kosinová, Pavlo Potalitsyn, Pavel Šácha, Romana Hadravová, Irena Selicharová, Jan Kříž, Johan P. Turkenburg, Andrzej Marek Brzozowski, Jiří Jiráček, Lenka Žáková
Publikováno v:
Open Biology, Vol 10, Iss 10 (2020)
Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn2+-stabilized oligomers. However, the actual storage forms of this hormone and the impact of zinc ions on insulin production in vivo are no
Externí odkaz:
https://doaj.org/article/cd3027437e574e159af8775f069f9003
Autor:
Robin Kryštůfek, Pavel Šácha
Publikováno v:
MethodsX, Vol 6, Iss , Pp 2230-2236 (2019)
Advances in contactless acoustic liquid transfer technologies have unlocked opportunities to substantially increase the throughput of crystallization screens and decrease the consumption of reagents and consumables. Acoustic energy transfer enables c
Externí odkaz:
https://doaj.org/article/ac498c808706470087fc53ab50e430b9
Autor:
Tomáš Knedlík, Barbora Vorlová, Václav Navrátil, Jan Tykvart, František Sedlák, Šimon Vaculín, Miloslav Franěk, Pavel Šácha, Jan Konvalinka
Publikováno v:
FEBS Open Bio, Vol 7, Iss 9, Pp 1362-1378 (2017)
Glutamate carboxypeptidase II (GCPII), also known as prostate‐specific membrane antigen (PSMA) or folate hydrolase, is a metallopeptidase expressed predominantly in the human brain and prostate. GCPII expression is considerably increased in prostat
Externí odkaz:
https://doaj.org/article/289a58f040874623959efd5bfbca5e3c
Autor:
Žofie Sovová, Jana Štikarová, Jiřina Kaufmanová, Pavel Májek, Jiří Suttnar, Pavel Šácha, Martin Malý, Jan E Dyr
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227543 (2020)
Oxidative stress in humans is related to various pathophysiological processes, which can manifest in numerous diseases including cancer, cardiovascular diseases, and Alzheimer's disease. On the atomistic level, oxidative stress causes posttranslation
Externí odkaz:
https://doaj.org/article/b66d743bf0ef4787aceb834b84d01d8c
Autor:
Lieselotte Vande Walle, Irma B Stowe, Pavel Šácha, Bettina L Lee, Dieter Demon, Amelie Fossoul, Filip Van Hauwermeiren, Pedro H V Saavedra, Petr Šimon, Vladimír Šubr, Libor Kostka, Craig E Stivala, Victoria C Pham, Steven T Staben, Sayumi Yamazoe, Jan Konvalinka, Nobuhiko Kayagaki, Mohamed Lamkanfi
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000529 (2019)
[This corrects the article DOI: 10.1371/journal.pbio.3000354.].
Externí odkaz:
https://doaj.org/article/608abbed317f4c6598fe817ed9e170da
Autor:
Lieselotte Vande Walle, Irma B Stowe, Pavel Šácha, Bettina L Lee, Dieter Demon, Amelie Fossoul, Filip Van Hauwermeiren, Pedro H V Saavedra, Petr Šimon, Vladimír Šubrt, Libor Kostka, Craig E Stivala, Victoria C Pham, Steven T Staben, Sayumi Yamazoe, Jan Konvalinka, Nobuhiko Kayagaki, Mohamed Lamkanfi
Publikováno v:
PLoS Biology, Vol 17, Iss 9, p e3000354 (2019)
The nucleotide-binding-domain (NBD)-and leucine-rich repeat (LRR)-containing (NLR) family, pyrin-domain-containing 3 (NLRP3) inflammasome drives pathological inflammation in a suite of autoimmune, metabolic, malignant, and neurodegenerative diseases.
Externí odkaz:
https://doaj.org/article/8bd2f4be33dd49be835f2a73d22da938
Autor:
Marcin Drąg, Jiří Brynda, Robin Kryštůfek, Jan Konvalinka, Eva Tloušt’ová, Martin Hradilek, Michael J. Boucher, Pavel Šácha, Justyna Grzymska, Pavlína Řezáčová, Miroslav Hájek, Jana Starková, Wioletta Rut, Charles S. Craik, Hiten D. Madhani, Pavel Majer
Publikováno v:
Journal of medicinal chemistry, vol 64, iss 10
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
Cryptococcosis is an invasive infection that accounts for 15% of AIDS-related fatalities. Still, treating cryptococcosis remains a significant challenge due to the poor availability of effective antifungal therapies and emergence of drug resistance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a574ed99162f75480cfa117cbef17e66
https://doi.org/10.1021/acs.jmedchem.0c02177
https://doi.org/10.1021/acs.jmedchem.0c02177