Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Pavel Pihera"'
Publikováno v:
Tetrahedron Letters. 48:6970-6973
Allylic thioethers of the general structure 1 underwent E / Z isomerization during both basic and acidic hydrolysis of the ester moiety at the remote end of the molecule. The isomerization was dependent on the substitution of the allylic moiety. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::159786df9d0467470c739c504b4a5680
https://doi.org/10.1016/j.tetlet.2007.07.164
https://doi.org/10.1016/j.tetlet.2007.07.164
Autor:
Claus Bekker Jeppesen, Per Sauerberg, Eva Johansson, Marek Korínek, Miroslav Havranek, Søren Ebdrup, John Patrick Mogensen, Pavel Pihera, Ingrid Pettersson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4625-4629
Structure based ligand design was used in order to design a partial agonist for the PPARdelta receptor. The maximum activation in the transactivation assay was reduced from 87% to 39%. The crystal structure of the ligand binding domain of the PPARdel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3c894bfbf563953a6cf9ee898c7a6c3
https://doi.org/10.1016/j.bmcl.2007.05.079
https://doi.org/10.1016/j.bmcl.2007.05.079
Autor:
Jan Fleckner, Zdenek Polivka, Erik M. Wulff, John Patrick Mogensen, Pavel Pihera, Miroslav Havranek, Claus Bekker Jeppesen, Paul Stanley Bury, Per Sauerberg, Lone Jeppesen, Grith Skytte Olsen, Ingrid Pettersson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3198-3202
Computational analysis of the ligand binding pocket of the three PPAR receptor subtypes was utilized in the design of potent PPARα agonists. Optimum PPARα potency and selectivity were obtained with substituents having van der Waals volume around 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::355b407fe01b0f913fee47073389089f
https://doi.org/10.1016/j.bmcl.2007.03.015
https://doi.org/10.1016/j.bmcl.2007.03.015
Autor:
Miroslav Havranek, Vladimira Panajotova, Zdenek Polivka, Pavel Pihera, Ingrid Pettersson, Jens R. Daugaard, Lone Jeppesen, Elisabeth D. Galsgaard, Grith Skytte Olsen, Lars Ynddal, Erik M. Wulff, John Patrick Mogensen, Jan Fleckner, Claus Bekker Jeppesen, Per Sauerberg
Publikováno v:
Journal of Medicinal Chemistry. 50:1495-1503
The aim was to identify a novel selective PPARdelta agonist with full efficacy on free fatty acid (FFA) oxidation in vitro and plasma lipid correction in vivo. Using the triple PPARalpha,gamma,delta agonist 1 as the structural starting point, we want
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe75b0eaf309a58e5206c630178b947
https://doi.org/10.1021/jm061202u
https://doi.org/10.1021/jm061202u
Publikováno v:
Scopus-Elsevier
A new synthesis of the title compound based on the formation of the furan ring in the key step was elaborated. Methyl 2-methoxy[1]benzothieno[3,2-b][1]benzofuran-7-carboxylate (15) was prepared by this methodology as a new type of a core for liquid c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a56a7e7050f03c86cb9dfc56cc2e1c
https://doi.org/10.1135/cccc20001939
https://doi.org/10.1135/cccc20001939
Autor:
Pavel Pihera, Jiri Svoboda
Publikováno v:
Collection of Czechoslovak Chemical Communications. 65:58-76
Electrophilic substitution and metallation reactions of the title compound 1 were studied. Bromination, acetylation, benzoylation, formylation, and nitration usually afforded nonseparable mixtures of 2- and 7-substituted derivatives as the main produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34507270f099e2f603ff2a6b8a38d943
https://doi.org/10.1135/cccc20000058
https://doi.org/10.1135/cccc20000058
Publikováno v:
Collection of Czechoslovak Chemical Communications. 64:389-407
2-Vinyl- (2) and 3-vinyl[1]benzothieno[3,2-b]furan (3) react with dimethyl acetylenedicarboxylate, methyl propiolate, maleic anhydride, or acrylonitrile endo-selectively as dienes to afford new [1]benzothieno[3,2-b][1]benzofuran derivatives 7-20. cis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76b35595dac5e66297168b60dd0d0ce3
https://doi.org/10.1135/cccc19990389
https://doi.org/10.1135/cccc19990389
Publikováno v:
Collection of Czechoslovak Chemical Communications. 63:681-697
[1]Benzothieno[3,2-b]furan reacts with substituted dienes 2 as a dienophile under formation of substituted tetrahydro[1]benzothieno[3,2-b][1]benzofuran derivatives 3-14. The cycloaddition is endo-stereoselective. Aromatization of the products leads t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db7c88faa02a11325a7a368867cd31fe
https://doi.org/10.1135/cccc19980681
https://doi.org/10.1135/cccc19980681
Publikováno v:
Collection of Czechoslovak Chemical Communications. 62:1468-1480
Thieno[3,2-b]benzofuran was synthesized starting from benzo[b]furan-3(2H)-one or benzo[b]furan-2-carbaldehyde. Electrophilic substitution reactions such as bromination, formylation, acetylation or nitration, take place in position 2. An electron dona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::807236b8d3ce74fc00c9c7bca5626768
https://doi.org/10.1135/cccc19971468
https://doi.org/10.1135/cccc19971468
Publikováno v:
Collection of Czechoslovak Chemical Communications. 61:888-900
In chlorination, bromination, iodination, nitration, sulfonation, formylation, and trifluoroacetylation of [1]benzothieno[3,2-b]furan (1) the substituent enters the 2-position. The said halogenations go by the addition-elimination mechanism. When the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a834be7945a9b8fd3b0c40b5d7a0b167
https://doi.org/10.1135/cccc19960888
https://doi.org/10.1135/cccc19960888