Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Pavel Michalek"'
Autor:
Zuzana Bielcikova, Lukas Werner, Jan Stursa, Vladimir Cerny, Ludmila Krizova, Jan Spacek, Stanislav Hlousek, Michal Vocka, Olga Bartosova, Michal Pesta, Katarina Kolostova, Petr Klezl, Vladimir Bobek, Jaroslav Truksa, Sona Stemberkova-Hubackova, Lubos Petruzelka, Pavel Michalek, Jiri Neuzil
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Mitochondrially targeted anticancer drugs (mitocans) that disrupt the energy-producing systems of cancer are emerging as new potential therapeutics. Mitochondrially targeted tamoxifen (MitoTam), an inhibitor of mitochondrial respiration respiratory c
Externí odkaz:
https://doaj.org/article/269f239884f64e4ea206c5d48ff311b3
Autor:
Emil Berta, Josef Srovnal, Petr Dytrych, Jan Bruthans, Jitka Ulrichova, Petr Prasil, Lubomir Vecera, Tomas Gabrhelik, Benjamin Tolmaci, Josef Dusa, Jan Maca, Michelle Mazancova, Filip Haiduk, Martin Kutej, Peter Ihnat, Pavel Michalek, Marian Hajduch
Publikováno v:
BMC Anesthesiology, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background Opioids and epidural analgesia are a mainstay of perioperative analgesia but their influence on cancer recurrence remains unclear. Based on retrospective data, we found that cancer recurrence following colorectal cancer surgery co
Externí odkaz:
https://doaj.org/article/8193a89a583c4cdea537cf24eeeb7c67
Autor:
Zuzana Bielcikova, Jan Stursa, Ludmila Krizova, Lanfeng Dong, Jan Spacek, Stanislav Hlousek, Michal Vocka, Katerina Rohlenova, Olga Bartosova, Vladimir Cerny, Tomas Padrta, Michal Pesta, Pavel Michalek, Sona Stemberkova Hubackova, Katarina Kolostova, Eliska Pospisilova, Vladimir Bobek, Peter Klezl, Renata Zobalova, Berwini Endaya, Jakub Rohlena, Lubos Petruzelka, Lukas Werner, Jiri Neuzil
Publikováno v:
EClinicalMedicine, Vol 57, Iss , Pp 101873- (2023)
Summary: Background: Mitochondria present an emerging target for cancer treatment. We have investigated the effect of mitochondrially targeted tamoxifen (MitoTam), a first-in-class anti-cancer agent, in patients with solid metastatic tumours. Methods
Externí odkaz:
https://doaj.org/article/91ab15755d5b4f4c9326f015bc30ba5c
Autor:
Lubomir Vecera, Petr Prasil, Josef Srovnal, Emil Berta, Monika Vidlarova, Tomas Gabrhelik, Pavla Kourilova, Martin Lovecek, Pavel Skalicky, Jozef Skarda, Zdenek Kala, Pavel Michalek, Marian Hajduch
Publikováno v:
Cancers, Vol 15, Iss 16, p 4038 (2023)
Pancreatic cancer (PDAC) has a poor prognosis despite surgical removal and adjuvant therapy. Additionally, the effects of postoperative analgesia with morphine and piritramide on survival among PDAC patients are unknown, as are their interactions wit
Externí odkaz:
https://doaj.org/article/43f361d816b04cc9a9df7246f1244004
Fibrinogenolysis in Venom-Induced Consumption Coagulopathy after Viperidae Snakebites: A Pilot Study
Autor:
Jiri Valenta, Alzbeta Hlavackova, Zdenek Stach, Jana Stikarova, Marek Havlicek, Pavel Michalek
Publikováno v:
Toxins, Vol 14, Iss 8, p 538 (2022)
Envenomations that are caused by Viperidae snakebites are mostly accompanied by venom-induced consumption coagulopathy (VICC) with defibrination. The clinical course of VICC is well described; however, reports about its detailed effects in the hemoco
Externí odkaz:
https://doaj.org/article/fd3578a7c09349698649e945fb790ea8
Autor:
Gabriela Grusova, Radan Bruha, Bianka Bircakova, Matej Novak, Lukas Lambert, Pavel Michalek, Grus Tomas, Andrea Burgetova
Publikováno v:
Gastroenterology Research and Practice, Vol 2021 (2021)
Objective. To determine the association between COVID-19 infection and peripancreatic changes on CT as a sign of acute pancreatic injury. Methods. Retrospective analysis of CT examinations in patients with confirmed COVID-19 infection yielded 103 ins
Externí odkaz:
https://doaj.org/article/207ba762220a449786b131b6b61ebdf0
Publikováno v:
Diagnostics, Vol 12, Iss 2, p 513 (2022)
In patients with acute circulatory failure, fluid administration represents a first-line therapeutic intervention for improving cardiac output. However, only approximately 50% of patients respond to fluid infusion with a significant increase in cardi
Externí odkaz:
https://doaj.org/article/2152c85b19b94d799bd5827fa2e1e010
Publikováno v:
Diagnostics, Vol 11, Iss 3, p 575 (2021)
The review article is focused on developments in optical devices, other than laryngoscopes, in airway management and tracheal intubation. It brings information on advantages and limitations in their use, compares different devices, and summarizes ben
Externí odkaz:
https://doaj.org/article/30ece617946b447b995cea160d610adb
Publikováno v:
Diagnostics, Vol 10, Iss 12, p 1024 (2020)
Videolaryngoscopes may improve intubating conditions in obese patients. A total of 110 patients with a body mass index > 35 kg∙m−2 were prospectively randomized to tracheal intubation using non-channeled Glidescope Titanium or channeled King Visi
Externí odkaz:
https://doaj.org/article/869828880f9c418c94e486bd1dc50dbe
Autor:
Jan Matek, Stanislav Cernohorsky, Stanislav Trca, Zdenek Krska, David Hoskovec, Jan Bruthans, Martin Sima, Pavel Michalek
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 5, p 1395 (2020)
Background: The aim of this study was to compare plasma levobupivacaine concentrations in thoracic epidural and subpleural paravertebral analgesia. Methods: Forty-four patients indicated for open lung resection had an epidural catheter inserted preop
Externí odkaz:
https://doaj.org/article/e2952a4258684c37b71e6bbb04dad6cd