Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Pavel Kasatsky"'
Autor:
Daria S Vinogradova, Victor Zegarra, Elena Maksimova, Jose Alberto Nakamoto, Pavel Kasatsky, Alena Paleskava, Andrey L Konevega, Pohl Milón
Publikováno v:
PLoS Biology, Vol 18, Iss 1, p e3000593 (2020)
During host colonization, bacteria use the alarmones (p)ppGpp to reshape their proteome by acting pleiotropically on DNA, RNA, and protein synthesis. Here, we elucidate how the initiating ribosome senses the cellular pool of guanosine nucleotides and
Externí odkaz:
https://doaj.org/article/b125235495434d0f907a4142d204f90f
Autor:
Evgeny Pichkur, Pavel Kasatsky, Alena Paleskava, Alexander Myasnikov, Yury Polikanov, Ilya A. Osterman, Andrey Konevega
Publikováno v:
International Journal of Biomedicine, Vol 9, Iss Suppl_1, Pp S23-S23 (2019)
Background: Macrolide antibiotics bind in the nascent peptide exit tunnel (NPET) of the bacterial ribosome near the peptidyl transferase center. One of the second-generation macrolides, dirithromycin (DIR), differs from the parent erythromycin (ERY)
Externí odkaz:
https://doaj.org/article/b0e58deb649e414b902cde9807b69134
Autor:
Andrey Konevega, Evgeny Pichkur, Alena Paleskava, Pavel Kasatsky, Elena Maksimova, Daria Vinogradova, Yury Polikanov, Alexander Myasnikov
Publikováno v:
International Journal of Biomedicine, Vol 9, Iss Suppl_1, Pp S7-S7 (2019)
Background: About 50% of antibiotics used in the therapy of infectious diseases target bacterial 70S ribosomes. High resolution X-ray crystallographic studies allow us for determination of position of drug on the ribosome, but to elucidate the detail
Externí odkaz:
https://doaj.org/article/6576155958c04a7daa9a550d1b4e8450
Autor:
Ekaterina S. Komarova, Andrey G Tereshchenkov, Petr V. Sergiev, Dmitrii I. Shiriaev, Ilya A. Osterman, Alexander G. Myasnikov, Andrey L. Konevega, Yury S. Polikanov, Evgeny Pichkur, Alexey A. Bogdanov, Alena Paleskava, Pavel Kasatsky, Olga A. Dontsova
Publikováno v:
RNA
RNA, 2020, 26 (6), pp.715-723. ⟨10.1261/rna.073817.119⟩
RNA, 2020, 26 (6), pp.715-723. ⟨10.1261/rna.073817.119⟩
Macrolides are one of the most successful and widely used classes of antibacterials, which kill or stop the growth of pathogenic bacteria by binding near the active site of the ribosome and interfering with protein synthesis. Dirithromycin is a deriv
Autor:
Stanislav V Kirillov, Andrey L. Konevega, Daria S. Vinogradova, Elena Maksimova, Pavel Kasatsky, Alena Paleskava
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 9614, p 9614 (2021)
Volume 22
Issue 17
International Journal of Molecular Sciences, Vol 22, Iss 9614, p 9614 (2021)
Volume 22
Issue 17
The growth of the polypeptide chain occurs due to the fast and coordinated work of the ribosome and protein elongation factors, EF-Tu and EF-G. However, the exact contribution of each of these components in the overall balance of translation kinetics
Autor:
Daria S. Vinogradova, Pavel Kasatsky, Andrey L. Konevega, Elena Maksimova, Alena Paleskava, Pohl Milón, Victor Zegarra, Jose A. Nakamoto
Publikováno v:
CONCYTEC-Institucional
Consejo Nacional de Ciencia Tecnología e Innovación Tecnológica
instacron:CONCYTEC
PLoS Biology
PLoS Biology, Vol 18, Iss 1, p e3000593 (2020)
Consejo Nacional de Ciencia Tecnología e Innovación Tecnológica
instacron:CONCYTEC
PLoS Biology
PLoS Biology, Vol 18, Iss 1, p e3000593 (2020)
During host colonization, bacteria use the alarmones (p)ppGpp to reshape their proteome by acting pleiotropically on DNA, RNA, and protein synthesis. Here, we elucidate how the initiating ribosome senses the cellular pool of guanosine nucleotides and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab1fa80c0153e18c3c745438a437378
Autor:
Evgeny B, Pichkur, Alena, Paleskava, Andrey G, Tereshchenkov, Pavel, Kasatsky, Ekaterina S, Komarova, Dmitrii I, Shiriaev, Alexey A, Bogdanov, Olga A, Dontsova, Ilya A, Osterman, Petr V, Sergiev, Yury S, Polikanov, Alexander G, Myasnikov, Andrey L, Konevega
Publikováno v:
RNA
Macrolides are one of the most successful and widely used classes of antibacterials, which kill or stop the growth of pathogenic bacteria by binding near the active site of the ribosome and interfering with protein synthesis. Dirithromycin is a deriv
Autor:
Victor G Kartsev, Petr V. Sergiev, Ekaterina S. Komarova, Pavel Kasatsky, Andrey L. Konevega, Ilya A. Osterman, Olga A. Dontsova, Nelli F Khabibullina, Alexey A. Bogdanov, Yury S. Polikanov
Publikováno v:
Nucleic Acids Research
The emergence of multi-drug resistant bacteria is limiting the effectiveness of commonly used antibiotics, which spurs a renewed interest in revisiting older and poorly studied drugs. Streptogramins A is a class of protein synthesis inhibitors that t
Autor:
Daria S. Vinogradova, Elena Maksimova, Alexander G. Myasnikov, Andrey L. Konevega, Yury S. Polikanov, Evgeny Pichkur, Pavel Kasatsky, Alena Paleskava
Publikováno v:
International Journal of Biomedicine, Vol 9, Iss Suppl_1, Pp S7-S7 (2019)
Background: About 50% of antibiotics used in the therapy of infectious diseases target bacterial 70S ribosomes. High resolution X-ray crystallographic studies allow us for determination of position of drug on the ribosome, but to elucidate the detail
Autor:
Alena Paleskava, Pohl Milón, Victor Zegarra, Pavel Kasatsky, Daria S. Vinogradova, Elena Maksimova, Andrey L. Konevega
During host colonization, bacteria use the alarmone (p)ppGpp to reshape its proteome by acting pleiotropically on RNA and protein synthesis. Here, we elucidate how the translation Initiation Factor 2 (IF2) senses the cellular ppGpp to GTP ratio and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29b8ab2ce6bdf1bfa8403cd23f90599