Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Pavel K. Mykhailiuk"'
Autor:
Vadym V. Levterov, Yaroslav Panasiuk, Kateryna Sahun, Oleksandr Stashkevych, Valentyn Badlo, Oleh Shablykin, Iryna Sadkova, Lina Bortnichuk, Oleksii Klymenko-Ulianov, Yuliia Holota, Leonid Lachmann, Petro Borysko, Kateryna Horbatok, Iryna Bodenchuk, Yuliia Bas, Dmytro Dudenko, Pavel K. Mykhailiuk
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract The phenyl ring is a basic structural element in chemistry. Here, we show the design, synthesis, and validation of its new saturated bioisostere with improved physicochemical properties − 2-oxabicyclo[2.2.2]octane. The design of the struct
Externí odkaz:
https://doaj.org/article/40ae1c7eff7f48309d4252061fceaf57
Autor:
Pavel K. Mykhailiuk
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 16-24 (2015)
A one-pot reaction between C2F5CH2NH2·HCl, NaNO2 and electron-deficient alkynes gives C2F5-substituted pyrazoles in excellent yields. The transformation smoothly proceeds in dichloromethane/water, tolerates the presence of air, and requires no purif
Externí odkaz:
https://doaj.org/article/94f236d2a77e4854bfa97626ef620bf1
Autor:
Isaac F. Yu, Jenna L. Manske, Alejandro Diéguez-Vázquez, Antonio Misale, Alexander E. Pashenko, Pavel K. Mykhailiuk, Sergey V. Ryabukhin, Dmitriy M. Volochnyuk, John F. Hartwig
Publikováno v:
Nature Chemistry. 15:685-693
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b59c6234dfc6ddcb10b9dd3bce9c94e5
https://doi.org/10.1038/s41557-023-01159-4
https://doi.org/10.1038/s41557-023-01159-4
Autor:
Maximilian D. Palkowitz, Gabriele Laudadio, Simon Kolb, Jin Choi, Martins S. Oderinde, Tamara El-Hayek Ewing, Philippe N. Bolduc, TeYu Chen, Hao Zhang, Peter T. W. Cheng, Benxiang Zhang, Michael D. Mandler, Vanna D. Blasczak, Jeremy M. Richter, Michael R. Collins, Ryan L. Schioldager, Martin Bravo, T. G. Murali Dhar, Benjamin Vokits, Yeheng Zhu, Pierre-Georges Echeverria, Michael A. Poss, Scott A. Shaw, Sebastian Clementson, Nadia Nasser Petersen, Pavel K. Mykhailiuk, Phil S. Baran
Publikováno v:
Journal of the American Chemical Society. 144:17709-17720
A useful protocol for achieving decarboxylative cross-coupling (DCC) of redox-active esters (RAE, isolated or generated in situ) and halo(hetero)arenes is reported. This pragmatically focused study employs a unique Ag-Ni electrocatalytic platform to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819a89b6a46fa50243f166fcbe5654d1
https://doi.org/10.1021/jacs.2c08006
https://doi.org/10.1021/jacs.2c08006
Autor:
Volodymyr Ahunovych, Anton A. Klipkov, Maksym Bugera, Karen Tarasenko, Serhii Trofymchuk, Oleh Stanko, Andrii Boretskyi, Mykola Zheludenko, Iryna V. Sadkova, Pavel K. Mykhailiuk
CF3-cyclopropanes were prepared on a multigram scale by deoxyfluorination of cyclopropane carboxylic acids or their salts with sulfur tetrafluoride. For labile α-pyridine acetic acids, only the use of salts allowed to obtain the needed products. Der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afe86480577cea86c94691b43b8d605
https://doi.org/10.26434/chemrxiv-2023-qp012
https://doi.org/10.26434/chemrxiv-2023-qp012
Autor:
H. V. Rasika Dias, Pavel K. Mykhailiuk, Anurag Noonikara-Poyil, Andrii Boretskyi, Alvaro Muñoz-Castro
Publikováno v:
Chemical Science
Polyfluorinated, electron-withdrawing, and sterically demanding supporting ligands are of significant value in chemistry. Here we report the assembly and use of a bis(pyrazolyl)borate, [Ph2B(3-(SF5)Pz)2]− that combines all such features, and involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a2cd970595ccf77251a74f7d0da6df
http://europepmc.org/articles/PMC8580053
http://europepmc.org/articles/PMC8580053
Autor:
Halyna Kuznietsova, Petro Borysko, Alexander Rudnichenko, Dmytro L. Titikaiev, Serhii I. Sirobaba, Maksym V. Stambirskyi, Yurii V. Dmytriv, Iryna Pishel, Pavel K. Mykhailiuk, Tetiana Kostiuk
Publikováno v:
The Journal of Organic Chemistry. 86:12783-12801
A general practical approach to hetero(aromatic) and aliphatic P(O)Me2-substituted derivatives is elaborated. The key synthetic step was a [Pd]-mediated C-P coupling of (hetero)aryl bromides/iodides with HP(O)Me2. The P(O)Me2 substituent was shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29c5e84aa6708f70be401a08b3c1d0d8
https://doi.org/10.1021/acs.joc.1c01413
https://doi.org/10.1021/acs.joc.1c01413
Autor:
Yurii Kornii, Oleg Shablykin, Taras Tarasiuk, Oleksandr Stepaniuk, Vitaliy Matvienko, Danylo Aloshyn, Nataliia Zahorodniuk, Iryna V. Sadkova, Pavel K. Mykhailiuk
Publikováno v:
The Journal of organic chemistry.
The previously unknown difluoromethyl diazirines and the previously neglected trifluoromethyl-aliphatic diazirines were synthesized and characterized. Model photolabeling experiments and biological studies showed that these compounds could indeed be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba93e8a42ab602c39db1c0407bd54159
https://pubmed.ncbi.nlm.nih.gov/36399052
https://pubmed.ncbi.nlm.nih.gov/36399052
Autor:
Pavel K. Mykhailiuk, Volodymyr Ahunovych, Karen V. Tarasenko, Serhii A. Trofymchuk, Bohdan Razhyk, Sergey Semenov, Anton A. Klipkov, Maksym Ya. Bugera, Andrii Boretskyi
Publikováno v:
The Journal of Organic Chemistry. 86:12181-12198
A general approach to fluorinated (hetero)aromatic derivatives is elaborated. The key reaction is a deoxofluorination of substituted acetophenones with sulfur tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf77d9b2cb3f0121ab555367bf24e236
https://doi.org/10.1021/acs.joc.1c01518
https://doi.org/10.1021/acs.joc.1c01518
Autor:
Pavel K. Mykhailiuk
Publikováno v:
Chemical Reviews. 121:1670-1715
Fluorinated pyrazoles play an important role in medicinal chemistry, drug discovery, agrochemistry, coordination chemistry, and organometallic chemistry. Since the early 1990s, their popularity has grown exponentially. Moreover, more than 50% of all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb81a6a7a98b7d38edf34cb4c7f6554
https://doi.org/10.1021/acs.chemrev.0c01015
https://doi.org/10.1021/acs.chemrev.0c01015