Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Pavel I. Zimin"'
Autor:
Renjini Ramadasan-Nair, Jessica Hui, Pavel I Zimin, Leslie S Itsara, Philip G Morgan, Margaret M Sedensky
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188087 (2017)
Knockout of the mitochondrial complex I protein, NDUFS4, profoundly increases sensitivity of mice to volatile anesthetics. In mice carrying an Ndufs4lox/lox gene, adeno-associated virus expressing Cre recombinase was injected into regions of the brai
Externí odkaz:
https://doaj.org/article/4efd612cced64cdba94d5a75eebe7a2e
Autor:
Sangwook Jung, Pavel I. Zimin, Christian B. Woods, Ernst-Bernhard Kayser, Dominik Haddad, Colleen R. Reczek, Ken Nakamura, Jan-Marino Ramirez, Margaret M. Sedensky, Philip G. Morgan
Publikováno v:
Current biology : CB. 32(14)
The mechanisms of volatile anesthetic action remain among the most perplexing mysteries of medicine. Across phylogeny, volatile anesthetics selectively inhibit mitochondrial complex I, and they also depress presynaptic excitatory signaling. To explor
Autor:
Phil G. Morgan, Jan-Marino Ramirez, Margaret M. Sedensky, Pavel I. Zimin, Ernst-Bernhard Kayser, Christian B. Woods
Publikováno v:
British Journal of Anaesthesia. 120:1019-1032
Background The mechanisms of action of volatile anaesthetics are unclear. Volatile anaesthetics selectively inhibit complex I in the mitochondrial respiratory chain. Mice in which the mitochondrial complex I subunit NDUFS4 is knocked out [Ndufs4(KO)]
Autor:
Jessica Hui, Leslie S. Itsara, Renjini Ramadasan-Nair, Philip G. Morgan, Margaret M. Sedensky, Pavel I. Zimin
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188087 (2017)
PLoS ONE
PLoS ONE
Knockout of the mitochondrial complex I protein, NDUFS4, profoundly increases sensitivity of mice to volatile anesthetics. In mice carrying an Ndufs4lox/lox gene, adeno-associated virus expressing Cre recombinase was injected into regions of the brai
Publikováno v:
Biophysical Journal. 114:1a-2a
Publikováno v:
Journal of Biological Chemistry. 286:3693-3706
Neuroinflammation and associated neuronal dysfunction mediated by activated microglia play an important role in the pathogenesis of Alzheimer disease (AD). Microglia are activated by aggregated forms of amyloid-β protein (Aβ), usually demonstrated
Autor:
Xiang-Jun Zhou, Zhong-Wei Chen, George P. Miljanich, Heike Wulff, Yong-Xiang Wang, Bin Hao, Pavel I. Zimin
Publikováno v:
Xenobiotica
1. PAP-1 (5-(4-phenoxybutoxy)psoralen), a potent small-molecule blocker of the voltage-gated potassium Kv1.3 channel, is currently in preclinical development for psoriasis. This study was undertaken to identify the major phase I metabolites of PAP-1
Autor:
Bojan Garic, Cedrick Mahieux, Boris S. Zhorov, Silke B. Bodendiek, Pavel I. Zimin, Heike Wulff
Publikováno v:
Molecular Pharmacology. 78:588-599
Voltage-gated potassium channels (Kv) are targets for drugs of large chemical diversity. Although hydrophobic cations block Kv channels with Hill coefficients of 1, uncharged electron-rich (cationophilic) molecules often display Hill coefficients of
Autor:
Pavel I. Zimin, Ralf Köhler, Tim Schultz, Ananthakrishnan Sankaranarayanan, Christoph Busch, Joachim Hoyer, Girija Raman, Heike Wulff
Publikováno v:
Molecular Pharmacology. 75:281-295
Small-conductance (KCa2.1-2.3) and intermediate-conductance (KCa3.1) calcium-activated K+ channels are critically involved in modulating calcium-signaling cascades and membrane potential in both excitable and nonexcitable cells. Activators of these c
Autor:
Heike Wulff, Christine Beeton, Jamshid Tehranzadeh, Nathan Standifer, Stephen M Griffey, Werner W. Roeck, Christine J. LeeHealey, Philippe Azam, Brian S. Andrews, Alexandra Grino, Debra Counts, K. George Chandy, George A. Gutman, Kimber L. Stanhope, Ananthakrishnan Sankaranarayanan, Ping H. Wang, Katherine M. Mullen, Daniel Homerick, Pavel I. Zimin, Peter J. Havel, Michael W. Pennington, Aaron Kolski-Andreaco, Eric Wei, Peter A. Calabresi, Gerald T. Nepom, Hans Guenther Knaus
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 103, iss 46
Beeton, Christine; Wulff, Heike; Standifer, Nathan E; Azam, Philippe; Mullen, Katherine M; Pennington, Michael W; et al.(2006). Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.. Proceedings of the National Academy of Sciences of the United States of America, 103(46), 17414-17419. doi: 10.1073/pnas.0605136103. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/2647b9c5
Beeton, Christine; Wulff, Heike; Standifer, Nathan E; Azam, Philippe; Mullen, Katherine M; Pennington, Michael W; et al.(2006). Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.. Proceedings of the National Academy of Sciences of the United States of America, 103(46), 17414-17419. doi: 10.1073/pnas.0605136103. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/2647b9c5
Autoreactive memory T lymphocytes are implicated in the pathogenesis of autoimmune diseases. Here we demonstrate that disease-associated autoreactive T cells from patients with type-1 diabetes mellitus or rheumatoid arthritis (RA) are mainly CD4+CCR7