Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Pavel Hrbas"'
Autor:
Tomislav Barth, Václav Kašička, Jiřina Slaninová, Ivan Svoboda, Pavel Hrbas, Ivana Zoulíková, Jiri Velek
Publikováno v:
Collection of Czechoslovak Chemical Communications. 60:1229-1235
The vasoactive intestinal (poly)peptide (VIP) is a linear peptide containing 28 amino acid residues, whose primary structure indicates a low metabolic stability. The following VIP fragments, as potential metabolites, and their analogues were prepared
Autor:
Ivana Zoulíková, Tomislav Barth, Ivan Svoboda, Jiřina Slaninová, Pavel Hrbas, Václav Kašička, Jiri Velek
Publikováno v:
ChemInform. 27
The vasoactive intestinal (poly)peptide (VIP) is a linear peptide containing 28 amino acid residues, whose primary structure indicates a low metabolic stability. The following VIP fragments, as potential metabolites, and their analogues were prepared
Autor:
Ivo Bláha, Pavel Hrbas, Jan Pospíšek, Jiří Jiráček, Ivan Svoboda, Karel Ubik, Jiří Velek, Hans-Gregor Gattner, Dietrich Brandenburg, Tomislav Barth, Václav Kašička
Publikováno v:
Biological chemistry Hoppe-Seyler. 375(6)
New semisynthetic analogues of human insulin, modified in the C-terminal region of the B-chain, were prepared to refine our understanding of the importance of particular amino acid residues in the expression of hormone biological properties. The foll
Autor:
David H. Coy, Jiang Ning-Yi, Atilla Ertan, Wojciech J. Rossowski, Susan Zacharia, Pavel Hrbas
Publikováno v:
European journal of pharmacology. 203(3)
Following the recent discovery of a new substance P (SP) competitive pancreatic acini cell receptor antagonist containing a reduced peptide bond in place of the C-terminal peptide bond, a new series of full chain and short chain (heptapeptide and hex
Publikováno v:
Collection of Czechoslovak Chemical Communications. 46:270-277
The specificity of oxytocin antibodies prepared by immunizing a pig with oxytocin that had been bound to thyreoglobulin by means of carbodiimide, was investigated using oxytocin analogues modified in position 1,2,4 and 6. All the modifications (deami
Publikováno v:
Collection of Czechoslovak Chemical Communications. 45:2714-2723
Linear octapeptides were prepared by stepwise synthesis in solution. Cyclization by the method of active esters yielded analogues of deamino-1-carba-oxytocin with valine, leucine or isoleucine in position 4 instead of the glutamine residue. The basic
Publikováno v:
Collection of Czechoslovak Chemical Communications. 47:1654-1658
Two anti-oxytocin sera, raised using thyroglobulin-oxytocin conjugates as immunogens in a rabbit and a pig, have been compared. Differences in assay conditions gave rise to large differences in the apparent titre of the antisera, and altered the spec
Publikováno v:
Collection of Czechoslovak Chemical Communications. 46:1850-1855
The effectiveness of vasopressin analogues with prolonged antidiuretic action was related to their primary structure. Prolonged action was primarily due to the absence of the amino group of cysteine in position 1 of the peptide chain. The carba subst
Publikováno v:
Collection of Czechoslovak Chemical Communications. 49:2012-2023
A study was made of the influence of the so-called carba substitution of the disulphide bridge on the properties of inhibitors obtained by the introduction of deaminopenicillamine into position 1 of the oxytocin molecule. Two analogues - [dPen1]carba
Autor:
Izabela Derdowska, Tomislav Barth, Gotfryd Kupryszewski, Pavel Hrbas, Bernard Lammek, Jiřina Slaninová
Publikováno v:
Collection of Czechoslovak Chemical Communications. 54:3374-3380
Six analogues of d(CH2)5AVP, a vasopressin inhibitor, modified in positions 1, 2, 4, and 9 were synthesized and the effect of the modifications on the inhibitory potency was followed. Buly and lipophilic substitutions in position 1 in combination wit