Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Pavel Houdek"'
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Choroid plexus (ChP), the brain structure primarily responsible for cerebrospinal fluid production, contains a robust circadian clock, whose role remains to be elucidated. The aim of our study was to [1] identify rhythmically controlled cell
Externí odkaz:
https://doaj.org/article/6b21d36781ed4a658e38d2ef638de48d
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S930-S931 (2023)
Externí odkaz:
https://doaj.org/article/5f99624504c3483a90263d978c5d8a15
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S734- (2023)
Externí odkaz:
https://doaj.org/article/e253c50f92834ac8a891f1d1e85e6128
Autor:
Karolína Liška, Tereza Dočkal, Pavel Houdek, Martin Sládek, Vendula Lužná, Kateryna Semenovykh, Milica Drapšin, Alena Sumová
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 159, Iss , Pp 114292- (2023)
Lithium is an effective mood stabilizer, but the mechanism of its therapeutic action is not well understood. We investigated the effect of lithium on the circadian clock located in the ventricle barrier complex containing the choroid plexus (CP), a p
Externí odkaz:
https://doaj.org/article/50a62cb1ecf9431a891c3516b0805030
Publikováno v:
PLoS Biology, Vol 20, Iss 5 (2022)
The suprachiasmatic nuclei (SCN) of the hypothalamus harbor the central clock of the circadian system, which gradually matures during the perinatal period. In this study, time-resolved transcriptomic and proteomic approaches were used to describe fet
Externí odkaz:
https://doaj.org/article/898a468f6bd740fd8c821a49a6221634
Autor:
Shu-qun Shi, Carrie E. Mahoney, Pavel Houdek, Wenling Zhao, Matthew P. Anderson, Xinming Zhuo, Arthur Beaudet, Alena Sumova, Thomas E. Scammell, Carl Hirschie Johnson
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Normal neurodevelopment requires precise expression of the key ubiquitin ligase gene Ube3a. Comparing newly generated mouse models for Ube3a downregulation (models of Angelman syndrome) vs. Ube3a upregulation (models for autism), we find reciprocal e
Externí odkaz:
https://doaj.org/article/b41a57afdeb4418496ca592e63b055fe
Autor:
Martin R Ralph, Shu-Qun Shi, Carl H Johnson, Pavel Houdek, Tenjin C Shrestha, Priya Crosby, John S O'Neill, Martin Sládek, Adam R Stinchcombe, Alena Sumová
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008987 (2021)
Modification of the Per2 clock gene in mPer2Luc reporter mice significantly alters circadian function. Behavioral period in constant dark is lengthened, and dissociates into two distinct components in constant light. Rhythms exhibit increased bimodal
Externí odkaz:
https://doaj.org/article/e98516d1343e4612b43b371cca13078b
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2021)
During fetal stage, maternal circadian system sets the phase of the developing clock in the suprachiasmatic nuclei (SCN) via complex pathways. We addressed the issue of how impaired maternal signaling due to a disturbed environmental light/dark (LD)
Externí odkaz:
https://doaj.org/article/8d9bd1e05977435cb06579b3912ae9fa
Autor:
Tomas Petrasek, Iveta Vojtechova, Veronika Lobellova, Anna Popelikova, Martina Janikova, Hana Brozka, Pavel Houdek, Martin Sladek, Alena Sumova, Zdenka Kristofikova, Karel Vales, Ales Stuchlík
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
The McGill-R-Thy1-APP transgenic rat is an animal model of the familial form of Alzheimer's disease (AD). This model mirrors several neuropathological hallmarks of the disease, including the accumulation of beta-amyloid and the formation of amyloid p
Externí odkaz:
https://doaj.org/article/ea1a2d0726404d48b8f46734a99774d3