DXD Motif-Dependent and -Independent Effects of the Chlamydia trachomatis Cytotoxin CT166

Autor: Miriam Bothe, Pavel Dutow, Andreas Pich, Harald Genth, Andreas Klos

Publikováno v: Toxins, Vol 7, Iss 2, Pp 621-637 (2015)

The Gram-negative, intracellular bacterium Chlamydia trachomatis causes acute and chronic urogenital tract infection, potentially leading to infertility and ectopic pregnancy. The only partially characterized cytotoxin CT166 of serovar D exhibits a D

Externí odkaz: https://doaj.org/article/17befd583b7f4dc7a84a69511255778a

Temperature and host cell-dependent changes in virulence of Chlamydia pneumoniae CWL029 in an optimized mouse infection model

Autor: Katrin Janik, Robert Laudeley, Andreas Klos, Jenny Bode, Silke Glage, Kirsten Sommer, Robert Geffers, Pavel Dutow

Publikováno v: Pathogens and Disease. 73:1-8

The obligate intracellular bacterium Chlamydia (C.) pneumoniae causes respiratory infections and is associated with vascular diseases. To elucidate how temperature and host cells used for propagation alter chlamydial virulence, C. pneumoniae CWL0129

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea3d1377c6b078cf807fdb90ccdcd22
https://doi.org/10.1093/femspd/ftu001

The Complement C3a Receptor Is Critical in Defense against Chlamydia psittaci in Mouse Lung Infection and Required for Antibody and Optimal T Cell Response

Autor: Claudia Rheinheimer, Beate Fehlhaber, Jenny Bode, Oliver Pabst, Pavel Dutow, Rick A. Wetsel, Andreas Klos, Robert Laudeley, Silke Glage

Publikováno v: The Journal of Infectious Diseases. 209:1269-1278

The intracellular gram-negative pathogen Chlamydia psittaci causes psittacosis in birds. Transmission of C. psittaci to humans can lead to life-threatening pneumonia with systemic dissemination [1, 2]. Infections of cattle and other domestic animals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4553a5d939eb7a0aa5370d5e61b9f510
https://doi.org/10.1093/infdis/jit640

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4 + T cells

Autor: Andrew P. Cope, Giuseppina Arbore, Mark E. Cooper, Claudia Rheinheimer, Luke A. J. O'Neill, Warren J. Leonard, Alan Sher, Jörg Köhl, Pavel Dutow, Peter N. Monk, Trent M. Woodruff, Erin E. West, Avril A. B. Robertson, Zu Xi Yu, Rebecca C. Coll, Helen J. Lachmann, Katrin D. Mayer-Barber, Rosanne Spolski, Andreas Klos, Matthew Arno, Behdad Afzali, Claudia Kemper

Publikováno v: Arbore, G, Kemper, C, Afzali, B, Cope, A P & Arno, M 2016, ' T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells ', Science, vol. 352, no. 6292, aad1210 . https://doi.org/10.1126/science.aad1210

INTRODUCTIONThe inflammasomes and the complement system are traditionally viewed as quintessential components of innate immunity required for the detection and elimination of pathogens. Assembly of the NLRP3 inflammasome in innate immune cells contro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e3000e44fcd5015a2c57109082b2dc
https://doi.org/10.1126/science.aad1210

Features critical for membrane binding revealed by DivIVA crystal structure

Autor: María A. Oliva, Sven Halbedel, Stefan M.V. Freund, Leendert W. Hamoen, Pavel Dutow, Dmitry B. Veprintsev, Jan Löwe, Thomas A. Leonard

Publikováno v: The EMBO Journal. 29:1988-2001

DivIVA is a conserved protein in Gram-positive bacteria that localizes at the poles and division sites, presumably through direct sensing of membrane curvature. DivIVA functions as a scaffold and is vital for septum site selection during vegetative g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba3b0cf7222f2e028bbf5b9e216050c
https://doi.org/10.1038/emboj.2010.99