Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Pavel Drabina"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 684-691 (2024)
The new chiral ligands I–III based on derivatives of imidazolidin-4-one were synthesised and characterised. The catalytic activity and enantioselectivity of their corresponding copper(II) complexes were studied in asymmetric Henry reactions. It was
Externí odkaz:
https://doaj.org/article/9bdc2c9342f04da0a93913a2f5d4c7a7
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 438-445 (2022)
The human drugs – the antibiotic linezolid (1) and the anticoagulant rivaroxaban (2) – belong among modern pharmaceutics, which contain an oxazolidine-2-one moiety bearing a stereogenic center. The chirality of these drugs is a fundamental attrib
Externí odkaz:
https://doaj.org/article/eb7b560020e747b7bdf27cc618575c9e
Autor:
Pavel Drabina, Miloš Sedlák
Publikováno v:
ARKIVOC, Vol 2012, Iss 1, Pp 152-172 (2012)
Externí odkaz:
https://doaj.org/article/fae608657def4474a87bab0f9b604a67
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 2, Pp o413-o413 (2009)
The title molecule, C13H17ClN3OS+·Br−, consists of benzene and pyrrolidine rings and an S–C(NHCH3)2 group. The central C—N bond lengths in the S–C(NHCH3)2 fragment indicate partial double-bond character. Molecules are interconnected into cha
Externí odkaz:
https://doaj.org/article/21c85eab0eb44d8e885b16ab9b192f7b
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 2, Pp o411-o412 (2009)
In the title molecular salt, C11H13ClN3OS+·Br−, the C—N bond lengths in the –S–C(NH2)2 fragment indicate partial double-bond character of these bonds. The constituent ions are connected by N—H...Br bridges into Z-shaped chains. The supramo
Externí odkaz:
https://doaj.org/article/2acf15c4545e4f0b9741cd58491cc766
The human drugs – antibiotic Linezolid (1) and anticoagulant Rivaroxaban (2) – belongs among modern pharmaceutics, which contain oxazolidine-2-one moiety bearing stereogenic centre. The chirality of these drugs is fundamental attribute of their b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5be28de1f9ccf5d20ed7146098c0aeac
https://doi.org/10.3762/bxiv.2022.4.v1
https://doi.org/10.3762/bxiv.2022.4.v1
Autor:
Kamila Dostálová, Eva Horáková, Pavel Drabina, Jiří Váňa, Jakub Valtr, Jiří Hanusek, Aleš Růžička
Publikováno v:
ChemistrySelect. 4:3973-3979
Publikováno v:
Tetrahedron Letters. 60:99-101
A new synthetic approach towards the anticoagulant drug (S)-Rivaroxaban was described. This reaction sequence involved six steps overall, starting from commercially available and inexpensive N-(4-aminophenyl)morpholin-3-one. The stereogenic centre wa
Publikováno v:
Tetrahedron: Asymmetry. 28:791-796
The preparation of a new series of 2-(pyridine-2-yl)imidazolidine-4-thione derivatives is described. Their corresponding copper(II) complexes were found to be highly enantioselective catalysts for asymmetric Henry reactions (up to 98% ee). Immobiliza
Publikováno v:
Synthesis. 49:1613-1622
A straightforward reaction path towards chiral primary amines bearing α-amino acid and benzo[d]imidazole pendants has been developed. Six starting essential α-amino acids were converted into the target chiral amines in a four-step synthesis. The pr