Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Pavel Drǎsar"'
Autor:
Jarmila Králová, Michal Jurášek, Lucie Mikšátková, Anna Marešová, Jan Fähnrich, Petra Cihlářová, Pavel Drašar, Petr Bartůněk, Vladimír Král
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Fluorescent sterol probes, comprising a fluorophore connected to a sterol backbone by means of a linker, are promising tools for enabling high-resolution imaging of intracellular cholesterol. In this study, we evaluated how the size of the l
Externí odkaz:
https://doaj.org/article/9f4dc5143084469ea4450e9de614eba2
Autor:
Silvie Rimpelová, Michal Jurášek, Lucie Peterková, Jiří Bejček, Vojtěch Spiwok, Miloš Majdl, Michal Jirásko, Miloš Buděšínský, Juraj Harmatha, Eva Kmoníčková, Pavel Drašar, Tomáš Ruml
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 1933-1944 (2019)
Sesquiterpene lactones are secondary plant metabolites with sundry biological effects. In plants, they are synthesized, among others, for pesticidal and antimicrobial effects. Two such compounds, archangelolide and trilobolide of the guaianolide type
Externí odkaz:
https://doaj.org/article/e0555971933f45a6b2c7b8b8a83ca8e5
Publikováno v:
Molecules, Vol 27, Iss 7, p 2103 (2022)
Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites
Externí odkaz:
https://doaj.org/article/3f1b9bb1fa91402e899d4b30083e0f69
Heterocyclic sterol probes for live monitoring of sterol trafficking and lysosomal storage disorders
Autor:
Jarmila Králová, Michal Jurášek, Lucie Krčová, Bohumil Dolenský, Ivan Novotný, Michal Dušek, Zdeňka Rottnerová, Michal Kahle, Pavel Drašar, Petr Bartůněk, Vladimír Král
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract The monitoring of intracellular cholesterol homeostasis and trafficking is of great importance because their imbalance leads to many pathologies. Reliable tools for cholesterol detection are in demand. This study presents the design and synt
Externí odkaz:
https://doaj.org/article/0647f34dfb5f4375bc68e664338d2298
Autor:
Tomáš Zimmermann, Pavel Drašar, Silvie Rimpelová, Søren Brøgger Christensen, Vladimir A. Khripach, Michal Jurášek
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1640 (2020)
In spite of the impressing cytotoxicity of thapsigargin (Tg), this compound cannot be used as a chemotherapeutic drug because of general toxicity, causing unacceptable side effects. Instead, a prodrug targeted towards tumors, mipsagargin, was brought
Externí odkaz:
https://doaj.org/article/c335e2abb5e04335bd4422db12b687ae
Publikováno v:
Molecules, Vol 16, Iss 11, Pp 9357-9367 (2011)
Conjugates consisting of stigmasterol and L-phenylalanine, interconnected through short-chained dicarboxylic acyls by ester and amide bonds, respectively, were synthesized as potential low molecular weight/mass organic gelators (LMWGs/LMMGs). Their p
Externí odkaz:
https://doaj.org/article/79ba18b0be7f4e9089d4b212bfef07eb
Autor:
Satu Ikonen, Jitka Ulrichová, Erkki T. Kolehmainen, Adéla Galandáková, Jan Horníček, Pavel Drašar, Zdeněk Wimmer, Martina Wimmerová, Ondřej Jurček, Lucie Buřičová
Publikováno v:
Molecules, Vol 16, Iss 11, Pp 9404-9420 (2011)
Synthesis, detailed structural characterization (X-ray, NMR, MS, IR, elemental analysis), and studies of toxicity, antioxidant activity and bioavailability of unique potent anti-atherosclerotic succinobucol-steroid conjugates are reported. The conjug
Externí odkaz:
https://doaj.org/article/0818f7b140d54cec80e3866c50f7e822
Akademický článek
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Autor:
Vladimír Pouzar, I. V. Torgov, Sophia N. Ananchenko, Pavel Drǎsar, Ivan Černý, František Tureček, Miroslav Havel, Vera V. Egorova
Publikováno v:
Steroids. 53:107-129
Racemic 14 beta-hydroxy-3-methoxy-8 alpha,9 alpha-1,3,5(10)-estratriene-17-one (I), obtained by total synthesis, was converted into a derivative with alkoxycarbonyl-ethylenic side chain, rac-(20E)-21-methoxycarbonyl-19-nor-8 alpha,9 alpha-pregna- 1,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c16d94d1505a90455e9c6c0d8c19ad
https://doi.org/10.1016/0039-128x(89)90149-9
https://doi.org/10.1016/0039-128x(89)90149-9