Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Pavel Davizon‐Castillo"'
Autor:
Kiruphagaran Thangaraju PhD, Saini Setua PhD, Christina Lisk PhD, Delaney Swindle MS, Daniel Stephenson PhD, Monika Dzieciatkowska PhD, Derek R. Lamb BS, Parikshit Moitra PhD, David Pak MS, Kathryn Hassell MD, Gemlyn George MD, Rachelle Nuss MD, Pavel Davizon-Castillo MD, Kurt R. Stenmark MD, Angelo D’Alessandro PhD, David C. Irwin PhD, Paul W. Buehler PharmD, PhD
Publikováno v:
Clinical and Applied Thrombosis/Hemostasis, Vol 29 (2023)
Aberrant coagulation in sickle cell disease (SCD) is linked to extracellular vesicle (EV) exposure. However, there is no consensus on the contributions of small EVs (SEVs) and large EVs (LEVs) toward underlying coagulopathy or on their molecular carg
Externí odkaz:
https://doaj.org/article/4769d021364e45e397107d74814a04a5
Autor:
Christina Lisk, Francesca Cendali, David I. Pak, Delaney Swindle, Kathryn Hassell, Rachelle Nuss, Gemlyn George, Pavel Davizon-Castillo, Paul W. Buehler, Angelo D’Alessandro, David C. Irwin
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionHuman and murine sickle cell disease (SCD) associated pulmonary hypertension (PH) is defined by hemolysis, nitric oxide depletion, inflammation, and thrombosis. Further, hemoglobin (Hb), heme, and iron accumulation are consistently observ
Externí odkaz:
https://doaj.org/article/2b14caf86c4044b991f1322159efd216
Autor:
Pavel Davizon‐Castillo, Ayed Allawzi, Matthew Sorrells, Susan Fisher, Kristina Baltrunaite, Keith Neeves, Eva Nozik‐Grayck, Jorge DiPaola, Cassidy Delaney
Publikováno v:
Physiological Reports, Vol 8, Iss 5, Pp n/a-n/a (2020)
Abstract Serotonin (5‐HT) contributes to the pathogenesis of experimental neonatal pulmonary hypertension (PH) associated with bronchopulmonary dysplasia (BPD). Platelets are the primary source of circulating 5‐HT and is released upon platelet ac
Externí odkaz:
https://doaj.org/article/2db647b80d8e498eb505a0937c5d1f65
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244792 (2020)
Blood coagulation is central to myocardial ischemia and reperfusion (IR) injury. Studies on the light elicited circadian rhythm protein Period 2 (PER2) using whole body Per2-/- mice found deficient platelet function and reduced clotting which would b
Externí odkaz:
https://doaj.org/article/ac96ea949a694d8793e72a00a756a506
Autor:
James S. Chavez, Jennifer L. Rabe, Giovanny Hernandez, Taylor S. Mills, Katia E. Niño, Pavel Davizon-Castillo, Eric M. Pietras
Publikováno v:
Cells, Vol 11, Iss 4, p 680 (2022)
The transcription factor PU.1 is a critical regulator of lineage fate in blood-forming hematopoietic stem cells (HSC). In response to pro-inflammatory signals, such as the cytokine IL-1β, PU.1 expression is increased in HSC and is associated with my
Externí odkaz:
https://doaj.org/article/b3e5fe7c3d834606a607973c9699bafb
Autor:
Kärt Tomberg, Rami Khoriaty, Randal J Westrick, Heather E Fairfield, Laura G Reinholdt, Gary L Brodsky, Pavel Davizon-Castillo, David Ginsburg, Jorge Di Paola
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150852 (2016)
During the analysis of a whole genome ENU mutagenesis screen for thrombosis modifiers, a spontaneous 8 base pair (bp) deletion causing a frameshift in exon 27 of the Nbeal2 gene was identified. Though initially considered as a plausible thrombosis mo
Externí odkaz:
https://doaj.org/article/98304642cca449c39ad337c7502fcbad
Publikováno v:
Sub-cellular biochemistry. 102
Higher access to medical care, advanced diagnostic tools, and overall public health improvements have favored increased humans lifespan. With a growing proportion of older adults, the associated costs to care for ageing-associated conditions will con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ae208d8ec58cc9f384215fa04bb3d9c
https://pubmed.ncbi.nlm.nih.gov/36600139
https://pubmed.ncbi.nlm.nih.gov/36600139
Publikováno v:
Biochemistry and Cell Biology of Ageing: Part III Biomedical Science ISBN: 9783031214097
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::905ddef3517696f38ff50f98cc7ecd4f
https://doi.org/10.1007/978-3-031-21410-3_13
https://doi.org/10.1007/978-3-031-21410-3_13
Autor:
Guadalupe Rojas Sanchez, Orlando Esparza, Brandon McMahon, Giovanny Hernandez, Dennis Le, Travis Nemkov, Angelo D'Alessandro, Andrew Thorburn, José A. López, Pavel Davizon-Castillo
Publikováno v:
Blood. 140:9590-9591
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1b130358b935f7815de63b809ba9347
https://doi.org/10.1182/blood-2022-170014
https://doi.org/10.1182/blood-2022-170014
Autor:
Kelsey Hazegh, Fang Fang, Kathleen Kelly, Derek Sinchar, Ling Wang, Benjamin E. Zuchelkowski, Alexander C. Ufelle, Orlando Esparza, Pavel Davizon-Castillo, Grier P. Page, Tamir Kanias
Publikováno v:
Cellular signalling. 99
p38 MAPKs are key regulators of cellular adaptation to various stress stimuli, however, their role in mediating erythrocyte cell death and hemolysis is largely unknown. We hypothesized that activation of erythrocyte p38 MAPK is a common event in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1ee659bfe0990c2ca6ca37801058f8
https://pubmed.ncbi.nlm.nih.gov/36029940
https://pubmed.ncbi.nlm.nih.gov/36029940