Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Pavel A. Petukhov"'
Autor:
Olga V. Kryukova, Igor O. Islanov, Elena V. Zaklyazminskaya, Dmitry O. Korostin, Vera A. Belova, Valery V. Cheranev, Zhanna A. Repinskaia, Svetlana A. Tonevitskaya, Pavel A. Petukhov, Steven M. Dudek, Olga A. Kost, Denis V. Rebrikov, Sergei M. Danilov
Publikováno v:
Biomedicines, Vol 12, Iss 10, p 2410 (2024)
Backgrounds. Our recent analysis of 1200+ existing missense ACE mutations revealed that 400+ mutations are damaging and led us to hypothesize that carriers of heterozygous loss-of-function (LoF) ACE mutations (which result in low ACE levels) could be
Externí odkaz:
https://doaj.org/article/fec2d51505614ad39c00be20888d461e
Autor:
Valentina Z. Petukhova, Sammy Y. Aboagye, Matteo Ardini, Rachel P. Lullo, Francesca Fata, Margaret E. Byrne, Federica Gabriele, Lucy M. Martin, Luke N. M. Harding, Vamshikrishna Gone, Bikash Dangi, Daniel D. Lantvit, Dejan Nikolic, Rodolfo Ippoliti, Grégory Effantin, Wai Li Ling, Jeremy J. Johnson, Gregory R. J. Thatcher, Francesco Angelucci, David L. Williams, Pavel A. Petukhov
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Only praziquantel is available for treating schistosomiasis, a disease affecting more than 200 million people. Praziquantel-resistant worms have been selected for in the lab and low cure rates from mass drug administration programs suggest t
Externí odkaz:
https://doaj.org/article/be068dfc60f64b079ddfa79996f6b0e8
Autor:
Enikő E. Enyedi, Pavel A. Petukhov, Alexander J. Kozuch, Steven M. Dudek, Attila Toth, Miklós Fagyas, Sergei M. Danilov
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 940 (2024)
Angiotensin-converting enzyme (ACE) metabolizes a number of important peptides participating in blood pressure regulation and vascular remodeling. Elevated ACE expression in tissues (which is generally reflected by blood ACE levels) is associated wit
Externí odkaz:
https://doaj.org/article/038083bc31464e05af7b974b208a5f65
Autor:
Sergei M. Danilov, Ivan A. Adzhubei, Alexander J. Kozuch, Pavel A. Petukhov, Isolda A. Popova, Ananyo Choudhury, Dhriti Sengupta, Steven M. Dudek
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 162 (2024)
We hypothesized that subjects with heterozygous loss-of-function (LoF) ACE mutations are at risk for Alzheimer’s disease because amyloid Aβ42, a primary component of the protein aggregates that accumulate in the brains of AD patients, is cleaved b
Externí odkaz:
https://doaj.org/article/e763b4cce3564c67b2429676de18198f
Autor:
Alexander J. Kozuch, Pavel A. Petukhov, Miklos Fagyas, Isolda A. Popova, Matthew O. Lindeblad, Alexander P. Bobkov, Armais A. Kamalov, Attila Toth, Steven M. Dudek, Sergei M. Danilov
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 953 (2023)
Background: Angiotensin-converting enzyme (ACE) is highly expressed in renal proximal tubules, but ACE activity/levels in the urine are at least 100-fold lower than in the blood. Decreased proximal tubular ACE has been associated with renal tubular d
Externí odkaz:
https://doaj.org/article/37ffa1ef834b48a5bd66f1abd7a3e615
Autor:
Sergei M. Danilov, Mark S. Jain, Pavel A. Petukhov, Olga V. Kurilova, Valery V. Ilinsky, Pavel E. Trakhtman, Elena L. Dadali, Larisa M. Samokhodskaya, Armais A. Kamalov, Olga A. Kost
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 534 (2023)
Background: The angiotensin-converting enzyme (ACE) metabolizes a number of important peptides participating in blood pressure regulation and vascular remodeling. Elevated blood ACE is a marker for granulomatous diseases and elevated ACE expression i
Externí odkaz:
https://doaj.org/article/00369f129eb84ab5bb6ced7a49d92f27
Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition
Autor:
Zachariah Bertels, Harinder Singh, Isaac Dripps, Kendra Siegersma, Alycia F Tipton, Wiktor D Witkowski, Zoie Sheets, Pal Shah, Catherine Conway, Elizaveta Mangutov, Mei Ao, Valentina Petukhova, Bhargava Karumudi, Pavel A Petukhov, Serapio M Baca, Mark M Rasenick, Amynah A Pradhan
Publikováno v:
eLife, Vol 10 (2021)
Migraine is the sixth most prevalent disease worldwide but the mechanisms that underlie migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal-plasticity and is dependent on dynamic microtubules. Histone-deacet
Externí odkaz:
https://doaj.org/article/7606ea99f0624f14a360122dad495479
Autor:
Taha Y Taha, Varada Anirudhan, Umaporn Limothai, Daniel D Loeb, Pavel A Petukhov, Alan McLachlan
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008802 (2020)
Hepatitis B virus (HBV) is a worldwide health problem without curative treatments. Investigation of the regulation of HBV biosynthesis by class I and II histone deacetylases (HDACs) demonstrated that catalytically active HDAC5 upregulates HBV biosynt
Externí odkaz:
https://doaj.org/article/e7882e507e2e419a90c477b462d4985e
Autor:
Sergei M. Danilov, Ivan A. Adzhubei, Alex J. Kozuch, Pavel A. Petukhov, Isolda A. Popova, Ananyo Choudhury, Dhriti Sengupta, Steven M. Dudek
Amyloid Aβ42 (constituents of the protein aggregates in the brains of patients with Alzheimer’s disease (AD) cleaved by ACE, and thus, a decrease in tissue ACE activity (constitutive or ACE inhibitor-induced) could be risk factor for AD. We hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6896df07cf911f517c186394e1340d51
https://doi.org/10.21203/rs.3.rs-2570701/v1
https://doi.org/10.21203/rs.3.rs-2570701/v1
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186620 (2017)
The mechanism of action of histone deacetylase inhibitors (HDACi) is mainly attributed to the inhibition of the deacetylase catalytic activity for their histone substrates. In this study, we analyzed the abundance of class I HDACs in the cytosolic, n
Externí odkaz:
https://doaj.org/article/6de1295cd19f4df6ae3fb4ca7956d02d