Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Pavel, Savechenkov"'
Autor:
Jay B, Fell, John P, Fischer, Brian R, Baer, James F, Blake, Karyn, Bouhana, David M, Briere, Karin D, Brown, Laurence E, Burgess, Aaron C, Burns, Michael R, Burkard, Harrah, Chiang, Mark J, Chicarelli, Adam W, Cook, John J, Gaudino, Jill, Hallin, Lauren, Hanson, Dylan P, Hartley, Erik J, Hicken, Gary P, Hingorani, Ronald J, Hinklin, Macedonio J, Mejia, Peter, Olson, Jennifer N, Otten, Susan P, Rhodes, Martha E, Rodriguez, Pavel, Savechenkov, Darin J, Smith, Niranjan, Sudhakar, Francis X, Sullivan, Tony P, Tang, Guy P, Vigers, Lance, Wollenberg, James G, Christensen, Matthew A, Marx
Publikováno v:
Journal of medicinal chemistry. 63(13)
Capping off an era marred by drug development failures and punctuated by waning interest and presumed intractability toward direct targeting of KRAS, new technologies and strategies are aiding in the target's resurgence. As previously reported, the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc99717000ce420f505732f20b4224e4
https://pubmed.ncbi.nlm.nih.gov/32250617
https://pubmed.ncbi.nlm.nih.gov/32250617
Autor:
Joshua Ballard, Harrah Chiang, James G. Christensen, Kenneth Hee, Tony Pisal Tang, Brian R. Baer, Peter Olson, Henry J. Zecca, David Briere, Mark Joseph Chicarelli, Laurence E. Burgess, Karyn Bouhana, Jill Hallin, Matthew A. Marx, Lauren Hanson, Barbara J. Brandhuber, Michael Burkard, Fell Jay Bradford, Pavel Savechenkov, James F. Blake, John P. Fischer, Guy Vigers, Hicken Erik James, Niranjan Sudhakar, Kevin Davidson, Ronald Jay Hinklin, Macedonio J. Mejia, John Gaudino
Publikováno v:
ACS Medicinal Chemistry Letters. 9:1230-1234
[Image: see text] KRAS is the most frequently mutated driver oncogene in human cancer, and KRAS mutations are commonly associated with poor prognosis and resistance to standard treatment. The ability to effectively target and block the function of mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a511b6ef25dc7584d5aa3f9ed4d78a97
https://doi.org/10.1021/acsmedchemlett.8b00382
https://doi.org/10.1021/acsmedchemlett.8b00382
Autor:
Pushina, Mariia1, Koutnik, Petr1, Nishiyabu, Ryuhei2, Minami, Tsuyoshi3, Savechenkov, Pavel1, Anzenbacher, Jr., Pavel1 pavel@bgsu.edu
Publikováno v:
Chemistry - A European Journal. 4/3/2018, Vol. 24 Issue 19, p4879-4884. 6p.
Autor:
Stern, Alex T., Forman, Stuart A.
Publikováno v:
Anesthesiology; Jan2016, Vol. 124 Issue 1, p89-100, 12p
Autor:
James G. Christensen, Macedonia J. Mejia, Tony Pisal Tang, Joshua Ballard, Pavel Y. Savechenkov, Mark Joseph Chicarelli, Guy Vigers, Niranjan Sudhakar, James F. Blake, Peter D. Olson, Brian R. Baer, David Briere, Matthew A. Marx, Fell Jay Bradford, Michael R. Burkhard, Karyn Bouhana, Laurence E. Burgess, Jill Hallin, Harrah Chiang, John P. Fischer
Publikováno v:
Molecular Cancer Research. 18:B30-B30
The ability to effectively target mutated KRAS has remained elusive despite decades of research. By solving a highly informative set of ligand-complexed co-crystal structures coupled with iterative structure-based drug design, substituted tetrahydrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6886a9bb95b32c7a7f0ea987f77aeeb5
https://doi.org/10.1158/1557-3125.ras18-b30
https://doi.org/10.1158/1557-3125.ras18-b30