Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Pavel, Mader"'
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Autor:
Chetan K. Chana, Pierre Maisonneuve, Ganna Posternak, Nicolas G.A. Grinberg, Juline Poirson, Samara M. Ona, Derek F. Ceccarelli, Pavel Mader, Daniel J. St-Cyr, Victor Pau, Igor Kurinov, Xiaojing Tang, Dongjing Deng, Weiren Cui, Wenji Su, Letian Kuai, Richard Soll, Mike Tyers, Hannes L. Röst, Robert A. Batey, Mikko Taipale, Anne-Claude Gingras, Frank Sicheri
Publikováno v:
Journal of Medicinal Chemistry. 65:12725-12746
Targeted protein degradation (TPD) strategies exploit bivalent small molecules to bridge substrate proteins to an E3 ubiquitin ligase to induce substrate degradation. Few E3s have been explored as degradation effectors due to a dearth of E3-binding s
Autor:
Monica, Bubenik, Pavel, Mader, Philippe, Mochirian, Fréderic, Vallée, Jillian, Clark, Jean-François, Truchon, Alexander L, Perryman, Victor, Pau, Igor, Kurinov, Karl E, Zahn, Marie-Eve, Leclaire, Robert, Papp, Marie-Claude, Mathieu, Martine, Hamel, Nicole M, Duffy, Claude, Godbout, Matias, Casas-Selves, Jean-Pierre, Falgueyret, Prasamit S, Baruah, Olivier, Nicolas, Rino, Stocco, Hugo, Poirier, Giovanni, Martino, Alexanne Bonneau, Fortin, Anne, Roulston, Amandine, Chefson, Stéphane, Dorich, Miguel, St-Onge, Purvish, Patel, Charles, Pellerin, Stéphane, Ciblat, Thomas, Pinter, Francis, Barabé, Majida, El Bakkouri, Paranjay, Parikh, Christian, Gervais, Agnel, Sfeir, Yael, Mamane, Stephen J, Morris, W Cameron, Black, Frank, Sicheri, Michel, Gallant
Publikováno v:
Journal of medicinal chemistry. 65(19)
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective
Akademický článek
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Autor:
Alena Křenková, Zbyszek Otwinowski, Petr Pachl, Pavel Mader, Jana Škerlová, Daniela Šimčíková, Vladimír Křen, Michael Kotik, Jiří Brynda, Pavlína Řezáčová, Jana Kapešová
Publikováno v:
Acta Crystallographica Section D Structural Biology. 74:1078-1084
α-L-Rhamnosidases cleave terminal nonreducing α-L-rhamnosyl residues from many natural rhamnoglycosides. This makes them catalysts of interest for various biotechnological applications. The X-ray structure of the GH78 family α-L-rhamnosidase from
Autor:
Michael Prakesch, Rima Al-awar, Ahmed Aman, Pierre Maisonneuve, Lauren Caldwell, Derek F. Ceccarelli, Ganna Posternak, Theo Goullet de Rugy, Mikko Taipale, Igor Kurinov, Julia Kitaygorodsky, Pavel Mader, Karen Colwill, Gennady Poda, Brett Larsen, Anne-Claude Gingras, Kin Chan, Jeff Wrana, Ting Jin, Salima Daou, Marc Therrien, Stephen Orlicky, Hugo Lavoie, Daniel Durocher, Xiaojing Tang, Cassandra J. Wong, Frank Sicheri, David Uehling, Robert A. Batey, Zhe Yin, Stefan Maier
Publikováno v:
Nat Chem Biol
The RAF family kinases function in the RAS-ERK pathway to transmit signals from activated RAS to the downstream kinases MEK and ERK. This pathway regulates cell proliferation, differentiation and survival, enabling mutations in RAS and RAF to act as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d3e2daaba5123ff078df9ce3f29cce
https://europepmc.org/articles/PMC7862923/
https://europepmc.org/articles/PMC7862923/
Autor:
Mario Bakardiev, Václav Šícha, Pavel Mader, Milan Fábry, Petr Cigler, Pavlína Řezáčová, Bohumír Grüner, Kristýna Poncová, Jiří Brynda
Publikováno v:
Angewandte Chemie. 125:14005-14008
CA inhibitors: Human carbonic anhydrases (CAs) are diagnostic and therapeutic targets. Various carborane cages are shown to act as active-site-directed inhibitors, and substitution with a sulfamide group and other substituents leads to compounds with
Autor:
Pavlína Řezáčová, Jiří Brynda, Pavel Mader, Alba Chimirri, Petr Pachl, Stefano Agnello, Rosaria Gitto, Claudiu T. Supuran
Publikováno v:
Journal of Medicinal Chemistry; Vol 54
Isoquinolinesulfonamides inhibit human carbonic anhydrases (hCAs) and display selectivity toward therapeutically relevant isozymes. The crystal structure of hCA II in complex with 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamide r
Autor:
Maria Dubrovcakova, Pavel Mader, Jan Lakota, Ludovit Skultety, Zuzana Bílková, Barbora Jankovicova, Pavlina Rezacova, Zuzana Svobodova
Publikováno v:
Journal of Proteome Research. 9:5171-5179
This work employs an epitope mapping of carbonic anhydrase (CA), isoform I (CA I), for detection of the main immunodominant epitopes. Our interest has arisen from an observed spontaneous tumor regression in patients who developed an aplastic anemia t
Autor:
Martin Lepšík, Jan Řezáč, Adam Pecina, Jiří Brynda, Pavel Hobza, Jindřich Fanfrlík, Pavlína Řezáčová, Pavel Mader
Publikováno v:
The journal of physical chemistry. B. 117(50)
The crystal structures of two novel carborane-sulfamide inhibitors in the complex with human carbonic anhydrase II (hCAII) have been studied using QM/MM calculations. Even though both complexes possess the strongly interacting sulfamide···zinc ion